GRB10 - growth factor receptor bound protein 10 Gene

Homo sapiens

Also known as RSS; IRBP; MEG1; GRB-IR; Grb-10

Gene ID: 2887 | Gene type: protein coding

About GRB10

Cytogenetic location: 7p12.1 Genomic coordinates (GRCh38): 7:50,590,068-50,793,453 (from NCBI)

This gene has 26 transcripts (splice variants), 280 orthologues and 4 paralogues. Ubiquitous expression in thyroid (RPKM 6.6), kidney (RPKM 5.7) and 25 other tissues.

Summary

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of Receptor Tyrosine Kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with Insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]

GRB10 Products(8)

mRNA	Protein	Name
NM_001001549.3	NP_001001549.1	growth factor receptor-bound protein 10 isoform b
NM_001001550.3	NP_001001550.1	growth factor receptor-bound protein 10 isoform c
NM_001001555.3	NP_001001555.1	growth factor receptor-bound protein 10 isoform c
NM_001350814.2	NP_001337743.1	growth factor receptor-bound protein 10 isoform a
NM_001350815.2	NP_001337744.1	growth factor receptor-bound protein 10 isoform d
NM_001350816.3	NP_001337745.2	growth factor receptor-bound protein 10 isoform c
NM_001371008.1	NP_001357937.1	growth factor receptor-bound protein 10 isoform c
NM_001371009.1	NP_001357938.1	growth factor receptor-bound protein 10 isoform f

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	19648926	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8798570	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of Wnt signaling pathway	IDA IDA: Inferred from direct assay	17376403	GOA
involved in positive regulation of vascular endothelial growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	15060076	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of protein-containing complex	IDA IDA: Inferred from direct assay	20878056	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GRB10 Protein Structure

BPS

SH2

0
100
200
300
400
500
594 a.a.

Protein Preferred Names

Protein Names

growth factor receptor-bound protein 10

GRB10 adapter protein

GRB10 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GRB10	Q13322	EGFR	Homo sapiens	P00533	Ub Reconstruction	24658140
Intra	GRB10	Q13322	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	GRB10	Q13322	FLT3	Homo sapiens	P36888	Anti Bait CoIP	23246379
Intra	GRB10	Q13322	FLT3	Homo sapiens	P36888	Pull Down	23246379
Intra	GRB10	Q13322	FLT3	Homo sapiens	P36888	Anti Tag CoIP	23246379
Intra	GRB10	Q13322	INSR	Homo sapiens	P06213	Pull Down	9506989
Intra	GRB10	Q13322	INSR	Homo sapiens	P06213	Protein 3 Hybrid	9506989
Intra	GRB10	Q13322	SFN	Homo sapiens	P31947	Anti Tag CoIP	31980649
Intra	GRB10	Q13322	EPHB1	Homo sapiens	P54762	Pull Down	8798570
Intra	GRB10	Q13322	RCAN3	Homo sapiens	Q9UKA8	Validated Y2H	25814554

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Transient Neonatal Diabetes Mellitus

Diabetes Mellitus, Transient Neonatal	Tndm
Chromosome 6-Associated Transient Diabetes Mellitus	Dmtn
Diabetes Mellitus, 6q24-Related Transient Neonatal	Tndm1
Neonatal Diabetes Mellitus, Transient	Tndm -[Transient Neonatal Diabetes Mellitus]

Silver-Russell Syndrome 1

Silver-Russell Syndrome	Russell-Silver Syndrome
Silver-Russell Dwarfism	Rss
SRS1	Srs
Silver Russell Dwarfism	Russell Silver Syndrome
Silver Russell Syndrome

Spastic Paraplegia 17, Autosomal Dominant

Silver Syndrome	SPG17
Silver Spastic Paraplegia Syndrome	Spastic Paraplegia With Amyotrophy Of Hands And Feet
Hereditary Spastic Paraplegia 17	Autosomal Dominant Spastic Paraplegia Type 17
Spastic Paraplegia 17	Spastic Paraplegia-Amyotrophy Of Hands And Feet
Autosomal Dominant Spastic Paraplegia 17	Dhmn5b
Distal Hereditary Motor Neuropathy Type 5b	Paraplegia, Spastic, Autosomal Dominant, Type 17
Russell-Silver Syndrome	Neuronopathy, Distal Hereditary Motor, Type Vb

Mulchandani-Bhoj-Conlin Syndrome

MBCS	Maternal Uniparental Disomy Of Chromosome 20
Maternal Upd(20)	Upd(20)Mat
Uniparental Disomy, Maternal, Chromosome 20

Temple Syndrome

Uniparental Disomy, Maternal, Chromosome 14	Temple Syndrome Due To Paternal 14q32.2 Microdeletion
Paternal Del(14)(Q32.2)	Temple Syndrome Due To Paternal 14q32.2 Hypomethylation
Temple Syndrome Due To Maternal Uniparental Disomy Of Chromosome 14	Upd(14)Mat

Isolated Growth Hormone Deficiency, Type Ib

Isolated Growth Hormone Deficiency Type Ib	IGHD1B
Ighd Ib	Growth Hormone Deficiency, Isolated, Type Ib
Congenital Ighd Type Ib	Congenital Isolated Gh Deficiency Type Ib
Congenital Isolated Growth Hormone Deficiency Type Ib	Dwarfism Of Sindh
Pituitary Dwarfism I	Isolated Growth Hormone Deficiency Type 1b
Ighd 1b	Growth Hormone Deficiency, Isolated, 1b

Beckwith-Wiedemann Syndrome

Wiedemann-Beckwith Syndrome	BWS
Exomphalos-Macroglossia-Gigantism Syndrome	Emg Syndrome
Beckwith-Wiedemann Syndrome Due To Cdkn1c Mutation	Emg Abnormality
Wbs	Exomphalos Macroglossia Gigantism Syndrome
Beckwith-Wiedemann Syndrome Due To Nsd1 Mutation	Macroglossia Exomphalos Gigantism

Kagami-Ogata Syndrome

Paternal Uniparental Disomy Of Chromosome 14	Uniparental Disomy, Paternal, Chromosome 14
Kos	Mca Due To 14q32.2 Maternally Expressed Gene Defect
Paternal Uniparental Disomy 14	Kagami-Ogata Syndrome Due To Maternal 14q32.2 Microdeletion
Maternal Del(14)(Q32.2)	Maternal Monosomy 14q32.2
Kagami-Ogata Syndrome Due To Maternal 14q32.2 Hypermethylation	Kagami-Ogata Syndrome Due To Paternal Uniparental Disomy Of Chromosome 14
Upd(14)Pat

Osteogenesis Imperfecta, Type Iii

Osteogenesis Imperfecta Type Iii	OI3
Oi, Type Iii	Osteogenesis Imperfecta Type 3
Oi Type Iii	Oi Type 3
Progressive Deforming Osteogenesis Imperfecta	Severe Osteogenesis Imperfecta
Osteogenesis Imperfecta, Progressively Deforming, With Normal Sclerae	Progressively Deforming Osteogenesis Imperfecta With Normal Sclera
Osteogenesis Imperfecta, Progressively Deforming With Normal Sclerae	Progressively Deforming Oi
Osteogenesis Imperfecta 3	Oi-Iii
Progressively Deforming Osteogenesis Imperfecta With Normal Sclerae

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05778	GRB10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GRB10	VGNC	VGNC:67456
Bos taurus	GRB10	VGNC	VGNC:29629
Macaca mulatta	GRB10	VGNC	VGNC:73157
Mus musculus	GRB10	MGD	MGI:103232
Canis familiaris	GRB10	VGNC	VGNC:51874
Rattus norvegicus	GRB10	RGD	RGD:1566234

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