PLAAT3 - phospholipase A and acyltransferase 3 Gene

Homo sapiens

Also known as AdPLA; HRSL3; HRASLS3; HREV107; PLA2G16; PLAAT-3; H-REV107; HREV107-1; HREV107-3; H-REV107-1

Gene ID: 11145 | Gene type: protein coding

About PLAAT3

Cytogenetic location: 11q12.3-q13.1 Genomic coordinates (GRCh38): 11:63,574,462-63,616,927 (from NCBI)

This gene has 6 transcripts (splice variants), 221 orthologues and 7 paralogues. Biased expression in fat (RPKM 173.9), testis (RPKM 32.8) and 11 other tissues.

Summary

Enables N-acyltransferase activity; Phospholipase A1 activity; and Phospholipase A2 activity. Involved in N-acylphosphatidylethanolamine metabolic process. Predicted to be located in several cellular components, including lysosome; nuclear envelope; and peroxisome. Predicted to be active in cytoplasm. Biomarker of seminoma. [provided by Alliance of Genome Resources, Apr 2022]

PLAAT3 Products(2)

mRNA	Protein	Name
NM_001128203.2	NP_001121675.1	phospholipase A and acyltransferase 3
NM_007069.3	NP_009000.2	phospholipase A and acyltransferase 3

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables N-acyltransferase activity	IDA IDA: Inferred from direct assay	22825852	GOA
enables lipid binding	EXP EXP: Inferred from Experiment	22605381	GOA
enables phospholipase A1 activity	IDA IDA: Inferred from direct assay	19047760	GOA
enables phospholipase A2 activity	IDA IDA: Inferred from direct assay	19047760	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in N-acylphosphatidylethanolamine metabolic process	IDA IDA: Inferred from direct assay	22825852	GOA
involved in phospholipid metabolic process	IDA IDA: Inferred from direct assay	20100577	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLAAT3 Protein Structure

LRAT

0
100
162 a.a.

Protein Preferred Names

Protein Names

phospholipase A and acyltransferase 3

Ca-independent phospholipase A1/2

PLAAT3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PLAAT3	P53816	UBQLN1	Homo sapiens	Q9UMX0-2	Y2H Prey Pooling	25416956
Intra	PLAAT3	P53816	UBQLN1	Homo sapiens	Q9UMX0-2	Validated Y2H	25416956
Intra	PLAAT3	P53816	PPP2R1A	Homo sapiens	P30153	Confocal	17374643
Intra	PLAAT3	P53816	PPP2R1A	Homo sapiens	P30153	Anti Bait CoIP	17374643
Intra	PLAAT3	P53816	PPP2R1A	Homo sapiens	P30153	Pull Down	17374643
Intra	PLAAT3	P53816	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	25416956
Intra	PLAAT3	P53816	UBQLN1	Homo sapiens	Q9UMX0	Y2H Pooling	16189514
Intra	PLAAT3	P53816	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32296183
Intra	PLAAT3	P53816	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	25416956
Intra	PLAAT3	P53816	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	32296183
Intra	PLAAT3	P53816	UBQLN1	Homo sapiens	Q9UMX0	Y2H Prey Pooling	32296183
Intra	PLAAT3	P53816	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	PLAAT3	P53816	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	PLAAT3	P53816	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PLAAT3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71211	PLA2G16 Protein, Human (His)	P53816 (D12-D132)	≥95%

Related Diseases

Diseases

Alias

Poland Syndrome

Poland Anomaly	Poland Sequence
Poland Syndactyly	Poland'S Syndrome
Poland'S Anomaly	Poland'S Syndactyly
Acro-Pectoro-Renal Field Defect	Brachydactyly, Absent Pectoral Muscles And Agenesis/Hypoplasia Of Kidneys
Unilateral Defect Of Pectoralis Muscle And Syndactyly Of The Hand	Unilateral Defect Of Pectoralis Major And Syndactyly Of The Hand

Acute Flaccid Myelitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10638	PLAAT3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PLAAT3	RGD	RGD:2829
Mus musculus	PLAAT3	MGD	MGI:2179715
Macaca mulatta	PLAAT3	VGNC	VGNC:76055
Canis familiaris	PLAAT3	VGNC	VGNC:57387

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