2. Gene
  3. CAVIN3 - caveolae associated protein 3 Gene

CAVIN3 - caveolae associated protein 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SRBC; HSRBC; PRKCDBP; cavin-3

Gene ID: 112464 | Gene type: protein coding

About CAVIN3

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:6,318,946-6,320,501 (from NCBI)

This gene has 4 transcripts (splice variants), 266 orthologues and 3 paralogues. Broad expression in fat (RPKM 24.8), testis (RPKM 13.9) and 19 other tissues.

Summary

The protein encoded by this gene was identified as a binding protein of the protein kinase C, delta (PRKCD). The expression of this gene in cultured cell lines is strongly induced by serum starvation. The expression of this protein was found to be down-regulated in various Cancer cell lines, suggesting the possible tumor suppressor function of this protein. [provided by RefSeq, Jul 2008]

CAVIN3 Products(1)

mRNA Protein Name
NM_145040.3 NP_659477.2 caveolae-associated protein 3
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
19262564 GOA
Cellular Component GO Annotation Evidence Reference Source
located in caveola IDA
IDA: Inferred from direct assay
19525939 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
24013648 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAVIN3 Protein Structure

PTRF_SDPR

PTRF_SDPR: PTRF/SDPR family (19 - 223)

  • 0
  • 100
  • 200
  • 261 a.a.
Protein Preferred Names Protein Names

caveolae-associated protein 3

protein kinase C delta binding protein

CAVIN3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CAVIN3 Q969G5 TIMM8A Homo sapiens O60220
Y2H Array
32296183
Intra
CAVIN3 Q969G5 TIMM8A Homo sapiens O60220
Y2H Prey Pooling
32296183
Intra
CAVIN3 Q969G5 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
32296183
Intra
CAVIN3 Q969G5 TFIP11 Homo sapiens Q9UBB9
Y2H Array
32296183
Intra
CAVIN3 Q969G5 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
32296183
Intra
CAVIN3 Q969G5 EPS15L1 Homo sapiens Q9UBC2
Anti Tag CoIP
19262564
Intra
CAVIN3 Q969G5 CAVIN1 Homo sapiens Q6NZI2
Anti Tag CoIP
24013648
Intra
CAVIN3 Q969G5 CAVIN1 Homo sapiens Q6NZI2
Y2H Array
32296183
Intra
CAVIN3 Q969G5 CAVIN1 Homo sapiens Q6NZI2
Y2H Prey Pooling
32296183
Intra
CAVIN3 Q969G5 NUP62 Homo sapiens P37198
Y2H Prey Pooling
32296183
Intra
CAVIN3 Q969G5 NUP62 Homo sapiens P37198
Y2H Array
32296183
Intra
CAVIN3 Q969G5 TPM3 Homo sapiens P06753
Y2H Array
32296183
Intra
CAVIN3 Q969G5 TPM3 Homo sapiens P06753
Y2H Prey Pooling
32296183
Intra
CAVIN3 Q969G5 GPRASP2 Homo sapiens Q96D09
Validated Y2H
32296183
Intra
CAVIN3 Q969G5 GPRASP2 Homo sapiens Q96D09
Y2H Array
32296183
Intra
CAVIN3 Q969G5 GPRASP2 Homo sapiens Q96D09
Y2H Prey Pooling
32296183
Intra
CAVIN3 Q969G5 GOLGA6L9 Homo sapiens A6NEM1
Y2H Prey Pooling
32296183
Intra
CAVIN3 Q969G5 GOLGA6L9 Homo sapiens A6NEM1
Y2H Array
32296183
Intra
CAVIN3 Q969G5 CAV1 Homo sapiens Q03135
IF
19262564
Intra
CAVIN3 Q969G5 CAV1 Homo sapiens Q03135
Anti Tag CoIP
19262564
Intra
CAVIN3 Q969G5 CAV1 Homo sapiens Q03135
Anti Tag CoIP
24013648
Intra
CAVIN3 Q969G5 MAGEA11 Homo sapiens P43364
Y2H Prey Pooling
32296183
Intra
CAVIN3 Q969G5 MAGEA11 Homo sapiens P43364
Y2H Array
32296183
Intra
CAVIN3 Q969G5 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
32296183
Intra
CAVIN3 Q969G5 CEP70 Homo sapiens Q8NHQ1
Y2H Array
32296183
Intra
CAVIN3 Q969G5 CEP76 Homo sapiens Q8TAP6
Y2H Prey Pooling
32296183
Intra
CAVIN3 Q969G5 CEP76 Homo sapiens Q8TAP6
Y2H Array
32296183
Intra
CAVIN3 Q969G5 MRFAP1L1 Homo sapiens Q96HT8
Y2H Array
32296183
Intra
CAVIN3 Q969G5 MRFAP1L1 Homo sapiens Q96HT8
Y2H Prey Pooling
32296183
Intra
CAVIN3 Q969G5 MRFAP1L1 Homo sapiens Q96HT8
Validated Y2H
32296183
Intra
CAVIN3 Q969G5 MRFAP1L1 Homo sapiens Q96HT8
Validated Y2H
25416956
Intra
CAVIN3 Q969G5 MRFAP1 Homo sapiens Q9Y605
Validated Y2H
32296183
Intra
CAVIN3 Q969G5 MRFAP1 Homo sapiens Q9Y605
Y2H Prey Pooling
32296183
Intra
CAVIN3 Q969G5 MRFAP1 Homo sapiens Q9Y605
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Lipodystrophy, Congenital Generalized, Type 4

Congenital Generalized Lipodystrophy Type 4

CGL4

Berardinelli-Seip Congenital Lipodystrophy, Type 4, With Muscular Dystrophy

Lipodystrophy, Berardinelli-Seip Congenital, Type 4, With Muscular Dystrophy

Berardinelli-Seip Congenital Lipodystrophy Type 4 With Muscular Dystrophy

Generalized Congenital Lipodystrophy With Myopathy

Congenital Generalised Lipodystrophy Type 4

Generalised Congenital Lipodystrophy Type 4

Generalised Congenital Lipodystrophy With Myopathy

Generalized Congenital Lipodystrophy Type 4

Gcl4

Congenital Generalized Lipodystrophy 4

Berardinelli-Seip Congenital Lipodystrophy Type 4
Extracranial Neuroblastoma
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01990 CAVIN3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CAVIN3 VGNC VGNC:70693
Rattus norvegicus CAVIN3 RGD RGD:628755
Mus musculus CAVIN3 MGD MGI:1923422
Bos taurus CAVIN3 VGNC VGNC:26804
Felis catus CAVIN3 VGNC VGNC:81912
Canis familiaris CAVIN3 VGNC VGNC:38755