XPOT - exportin for tRNA Gene

Homo sapiens

Also known as XPO3

Gene ID: 11260 | Gene type: protein coding

About XPOT

Cytogenetic location: 12q14.2 Genomic coordinates (GRCh38): 12:64,404,392-64,451,125 (from NCBI)

This gene has 6 transcripts (splice variants) and 210 orthologues. Ubiquitous expression in thyroid (RPKM 36.4), brain (RPKM 13.8) and 25 other tissues.

Summary

This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN. [provided by RefSeq, Jul 2008]

XPOT Products(1)

mRNA	Protein	Name
NM_007235.6	NP_009166.2	exportin-T

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables tRNA binding	IDA IDA: Inferred from direct assay	9660920	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in tRNA export from nucleus	IDA IDA: Inferred from direct assay	9660920	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	9660920	GOA
part of nuclear pore	IDA IDA: Inferred from direct assay	9660920	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	9660920	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

XPOT Protein Structure

Xpo1

0
200
400
600
800
962 a.a.

Protein Preferred Names

Protein Names

exportin-T

exportin(tRNA)

Related Diseases

Diseases

Alias

Severe Congenital Neutropenia 6

Autosomal Recessive Severe Congenital Neutropenia Due To Jagn1 Deficiency

Scn6

Glaucoma, Normal Tension

Low Tension Glaucoma	Glaucoma, Normal Tension, Susceptibility To
Normal Tension Glaucoma	Ntg
Glaucoma, Normal Pressure	NPG
Glaucoma, Normal Pressure, Susceptibility To	Poag/Npg - [Normal Pressure Primary Open-Angle Glaucoma]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15894	XPOT Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	XPOT	VGNC	VGNC:67116
Rattus norvegicus	XPOT	RGD	RGD:1305562
Canis familiaris	XPOT	VGNC	VGNC:48465
Mus musculus	XPOT	MGD	MGI:1920442
Macaca mulatta	XPOT	VGNC	VGNC:100123
Bos taurus	XPOT	VGNC	VGNC:37002

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