TRA2A - transformer 2 alpha homolog Gene

Homo sapiens

Also known as AWMS1; HSU53209

Gene ID: 29896 | Gene type: protein coding

About TRA2A

Cytogenetic location: 7p15.3 Genomic coordinates (GRCh38): 7:23,504,780-23,531,981 (from NCBI)

This gene has 12 transcripts (splice variants), 214 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 46.2), endometrium (RPKM 25.7) and 25 other tissues.

Summary

This gene is a member of the transformer 2 homolog family and encodes a protein with several RRM (RNA recognition motif) domains. This phosphorylated nuclear protein binds to specific RNA sequences and plays a role in the regulation of pre-mRNA splicing. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]

TRA2A Products(7)

mRNA	Protein	Name
NM_001282757.2	NP_001269686.1	transformer-2 protein homolog alpha isoform 2
NM_001282758.2	NP_001269687.1	transformer-2 protein homolog alpha isoform 2
NM_001282759.2	NP_001269688.1	transformer-2 protein homolog alpha isoform 3
NM_001362759.2	NP_001349688.1	transformer-2 protein homolog alpha isoform 4
NM_001362760.2	NP_001349689.1	transformer-2 protein homolog alpha isoform 2
NM_001362761.2	NP_001349690.1	transformer-2 protein homolog alpha isoform 2
NM_013293.5	NP_037425.1	transformer-2 protein homolog alpha isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23602568	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	9546399	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	9546399	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRA2A Protein Structure

RRM_1

0
100
200
282 a.a.

Protein Preferred Names

Protein Names

transformer-2 protein homolog alpha

TRA-2 alpha

Related Diseases

Diseases

Alias

Malignant Pineal Area Germ Cell Neoplasm

Pineal Germ Cell Tumor	Malignant Pineal Parenchymal Germ Cell Tumor
Pineal Region Germ Cell Tumor	Pineal Cell Tumor
Pineal Cell Tumour	Pineal Region Germinoma
Malignant Pineal Region Germ Cell Tumor	Pineal Germinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14961	TRA2A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TRA2A	VGNC	VGNC:36267
Mus musculus	TRA2A	MGD	MGI:1933972
Canis familiaris	TRA2A	VGNC	VGNC:47758
Macaca mulatta	TRA2A	VGNC	VGNC:79040
Rattus norvegicus	TRA2A	RGD	RGD:1562563
Felis catus	TRA2A	VGNC	VGNC:66490

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