ECD - ecdysoneless cell cycle regulator Gene

Homo sapiens

Also known as GCR2; SGT1; HSGT1

Gene ID: 11319 | Gene type: protein coding

About ECD

Cytogenetic location: 10q22.2 Genomic coordinates (GRCh38): 10:73,133,668-73,168,095 (from NCBI)

This gene has 8 transcripts (splice variants) and 207 orthologues. Ubiquitous expression in testis (RPKM 14.0), thyroid (RPKM 12.4) and 25 other tissues.

Summary

Enables Histone Acetyltransferase binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ECD Products(3)

mRNA	Protein	Name
NM_001135752.1	NP_001129224.1	protein ecdysoneless homolog isoform 2
NM_001135753.1	NP_001129225.1	protein ecdysoneless homolog isoform 3
NM_007265.3	NP_009196.1	protein ecdysoneless homolog isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables histone acetyltransferase binding	IDA IDA: Inferred from direct assay	19919181	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23880345	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19919181	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19919181	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19919181	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ECD Protein Structure

SGT1

0
100
200
300
400
500
600
644 a.a.

Protein Preferred Names

Protein Names

protein ecdysoneless homolog

ecdysoneless homolog

ECD Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ECD	O95905	TXNIP	Homo sapiens	Q9H3M7	Pull Down	23880345
Intra	ECD	O95905	TXNIP	Homo sapiens	Q9H3M7	Anti Bait CoIP	23880345
Intra	ECD	O95905	TXNIP	Homo sapiens	Q9H3M7	Anti Tag CoIP	23880345
Intra	ECD	O95905	RUVBL1	Homo sapiens	Q9Y265	TAP	26711270
Intra	ECD	O95905	RUVBL1	Homo sapiens	Q9Y265	Pull Down	26711270
Intra	ECD	O95905	RUVBL1	Homo sapiens	Q9Y265	Anti Bait CoIP	26711270
Intra	ECD	O95905	PIH1D1	Homo sapiens	Q9NWS0	Anti Tag CoIP	24656813
Intra	ECD	O95905	PIH1D1	Homo sapiens	Q9NWS0	Anti Bait CoIP	26711270
Intra	ECD	O95905	PIH1D1	Homo sapiens	Q9NWS0	Pull Down	26711270
Intra	ECD	O95905	PIH1D1	Homo sapiens	Q9NWS0	Pull Down	24656813
Intra	ECD	O95905	PRPF8	Homo sapiens	Q6P2Q9	Anti Bait CoIP	26711270
Intra	ECD	O95905	PRPF8	Homo sapiens	Q6P2Q9	TAP	26711270
Intra	ECD	O95905	PRPF8	Homo sapiens	Q6P2Q9	Anti Tag CoIP	33961781
Intra	ECD	O95905	PRPF8	Homo sapiens	Q6P2Q9	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ECD Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74182	ECD Protein, Human (sf9, His-GST)	O95905-1 (M1-N644)	≥95%

Related Diseases

Diseases

Alias

Cerebral Primitive Neuroectodermal Tumor

Pnet Of Cerebrum

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99380	Zanidatamab	Inhibitor	/	Unkown

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18377	Bioymifi		≥98.0%	Unkown
HY-RS04132	ECD Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99963	Sudubrilimab	Inhibitor	/	Unkown
HY-P990759	Rezetamig		/	Unkown
HY-P990903	Avitotamig	Inhibitor	/	Unkown
HY-P991028	Surovatamig	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ECD	VGNC	VGNC:71852
Rattus norvegicus	ECD	RGD	RGD:1565023
Canis familiaris	ECD	VGNC	VGNC:40180
Felis catus	ECD	VGNC	VGNC:61706
Bos taurus	ECD	VGNC	VGNC:28301
Mus musculus	ECD	MGD	MGI:1917851
Macaca fascicularis	ECD	NCBI	NCBI:102129143
Others	ECD	NCBI

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