CTRC - chymotrypsin C Gene

Homo sapiens

Also known as CLCR; ELA4

Gene ID: 11330 | Gene type: protein coding

About CTRC

Cytogenetic location: 1p36.21 Genomic coordinates (GRCh38): 1:15,438,443-15,449,242 (from NCBI)

This gene has 4 transcripts (splice variants), 102 orthologues, 2 paralogues and is associated with 4 phenotypes. Restricted expression toward pancreas (RPKM 2413.6).

Summary

This gene encodes a member of the peptidase S1 family. The encoded protein is a serum calcium-decreasing factor that has chymotrypsin-like Protease activity. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

CTRC Products(1)

mRNA	Protein	Name
NM_007272.3	NP_009203.2	chymotrypsin-C preproprotein

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables peptidase activity	IDA IDA: Inferred from direct assay	8635596	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within intracellular calcium ion homeostasis	IDA IDA: Inferred from direct assay	8635596	GOA
acts upstream of or within proteolysis	IDA IDA: Inferred from direct assay	8635596	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CTRC Protein Structure

Trypsin

0
100
200
268 a.a.

Protein Preferred Names

Protein Names

chymotrypsin-C

caldecrin

Recombinant CTRC Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70098	CTRC Protein, Human (HEK293, His)	Q99895 (C17-L268)	≥95%

Related Diseases

Diseases

Alias

Pancreatitis, Hereditary

Hereditary Pancreatitis	Chronic Pancreatitis
Hereditary Chronic Pancreatitis	Hp
Pancreatitis, Chronic, Susceptibility To	PCTT
Hpc	Pancreatitis, Chronic
Pancreatitis, Chronic, Protection Against	Autosomal Dominant Hereditary Pancreatitis
Familial Pancreatitis	Cp
Pancreatitis Hereditary

Prss1-Related Hereditary Pancreatitis

Tropical Calcific Pancreatitis

Tropical Pancreatitis	TCP
Fibrocalculous Pancreatic Diabetes	Tropical Calcific Chronic Pancreatitis
Fibrocalculous Pancreatic Diabetes, Susceptibility To	Tcp - [Tropical Chronic Pancreatitis]

Pancreatitis

Mumps Pancreatitis

Acute Pancreatitis

Pancreatitis	Pancreatitis, Acute Necrotizing
Pancreatitis Nos	Acute Pancreas Inflammation

Pancreas, Annular

Annular Pancreas	Pancreas Annulare
Congenital Annular Pancreas

Alcoholic Pancreatitis

Pancreatitis, Alcoholic

Pancreatitis Alcoholic

Bile Duct Cysts

Choledochal Cyst	Choledochal Cysts
Choledochocele	Biliary Cyst
Congenital Choledochal Cyst	Bile Duct Cyst
Congenital Cystic Dilatation Of The Biliary Tract	Congenital Bile Duct Dilatation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03319	CTRC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CTRC	VGNC	VGNC:27811
Felis catus	CTRC	VGNC	VGNC:61263
Rattus norvegicus	CTRC	RGD	RGD:1308379
Mus musculus	CTRC	MGD	MGI:1923951
Others	CTRC	NCBI

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