RHPN1 - rhophilin Rho GTPase binding protein 1 Gene

Homo sapiens

Also known as ODF5; RHPN; RHOPHILIN

Gene ID: 114822 | Gene type: protein coding

About RHPN1

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:143,364,255-143,384,221 (from NCBI)

This gene has 3 transcripts (splice variants), 191 orthologues and 1 paralogue. Broad expression in brain (RPKM 2.9), kidney (RPKM 2.5) and 22 other tissues.

Summary

Predicted to be involved in signal transduction. Predicted to act upstream of or within several processes, including focal adhesion assembly; glomerular filtration; and negative regulation of stress fiber assembly. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

RHPN1 Products(1)

mRNA	Protein	Name
NM_052924.3	NP_443156.2	rhophilin-1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RHPN1 Protein Structure

HR1

BRO1

PDZ

0
200
400
600
670 a.a.

Protein Preferred Names

Protein Names

rhophilin-1

GTP-Rho-binding protein 1

RHPN1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RHPN1	Q8TCX5	LZTS1	Homo sapiens	Q9Y250	Y2H Array	32296183
Intra	RHPN1	Q8TCX5	LZTS1	Homo sapiens	Q9Y250	Y2H Prey Pooling	32296183
Intra	RHPN1	Q8TCX5	LZTS1	Homo sapiens	Q9Y250	Validated Y2H	32296183
Intra	RHPN1	Q8TCX5	GPRASP2	Homo sapiens	Q96D09	Y2H Prey Pooling	32296183
Intra	RHPN1	Q8TCX5	GPRASP2	Homo sapiens	Q96D09	Validated Y2H	32296183
Intra	RHPN1	Q8TCX5	GPRASP2	Homo sapiens	Q96D09	Y2H Array	32296183
Intra	RHPN1	Q8TCX5	NEFL	Homo sapiens	P07196	Validated Y2H	32814053
Intra	RHPN1	Q8TCX5	NEFL	Homo sapiens	P07196	Y2H Pooling	32814053
Intra	RHPN1	Q8TCX5	NEFL	Homo sapiens	P07196	Y2H Array	32814053
Intra	RHPN1	Q8TCX5	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	RHPN1	Q8TCX5	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	RHPN1	Q8TCX5	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	RHPN1	Q8TCX5	GOLGA2	Homo sapiens	Q08379	Anti Tag CoIP	33961781
Intra	RHPN1	Q8TCX5	GOLGA2	Homo sapiens	Q08379	Anti Tag CoIP	28514442
Intra	RHPN1	Q8TCX5	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	RHPN1	Q8TCX5	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	RHPN1	Q8TCX5	HAP1	Homo sapiens	P54257	Y2H Prey Pooling	32296183
Intra	RHPN1	Q8TCX5	HAP1	Homo sapiens	P54257	Y2H Array	32296183
Intra	RHPN1	Q8TCX5	TRIM27	Homo sapiens	P14373	Y2H Array	25416956
Intra	RHPN1	Q8TCX5	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	RHPN1	Q8TCX5	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	RHPN1	Q8TCX5	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	RHPN1	Q8TCX5	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	32296183
Intra	RHPN1	Q8TCX5	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	32296183
Intra	RHPN1	Q8TCX5	MTUS2	Homo sapiens	Q5JR59	Validated Y2H	25416956
Intra	RHPN1	Q8TCX5	MTUS2	Homo sapiens	Q5JR59	Y2H Prey Pooling	25416956
Intra	RHPN1	Q8TCX5	GFAP	Homo sapiens	P14136	Y2H Array	32814053
Intra	RHPN1	Q8TCX5	GFAP	Homo sapiens	P14136	Y2H Pooling	32814053
Intra	RHPN1	Q8TCX5	GFAP	Homo sapiens	P14136	Validated Y2H	32814053
Intra	RHPN1	Q8TCX5	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	RHPN1	Q8TCX5	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	RHPN1	Q8TCX5	PEX1	Homo sapiens	O43933	Y2H Pooling	32814053
Intra	RHPN1	Q8TCX5	PEX1	Homo sapiens	O43933	Validated Y2H	32814053
Intra	RHPN1	Q8TCX5	PEX1	Homo sapiens	O43933	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Tracheal Calcification

Calcification Of Trachea

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11961	RHPN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RHPN1	VGNC	VGNC:45567
Macaca mulatta	RHPN1	VGNC	VGNC:76779
Bos taurus	RHPN1	VGNC	VGNC:33956
Rattus norvegicus	RHPN1	RGD	RGD:1305688
Felis catus	RHPN1	VGNC	VGNC:64620
Mus musculus	RHPN1	MGD	MGI:1098783

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