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  2. PTPMT1 - protein tyrosine phosphatase mitochondrial 1 Gene

PTPMT1 - protein tyrosine phosphatase mitochondrial 1 Gene

Homo sapiens

Also known as MOSP; PLIP; DUSP23; PNAS-129

Gene ID: 114971 | Gene type: protein coding

About PTPMT1

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:47,565,599-47,573,461 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 173 orthologues and 30 paralogues. Ubiquitous expression in testis (RPKM 16.1), brain (RPKM 11.9) and 25 other tissues.

Summary

Predicted to enable phosphatidylglycerophosphatase activity and phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Involved in regulation of intrinsic apoptotic signaling pathway. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

PTPMT1 Products(2)

mRNA Protein Name
NM_001143984.2 NP_001137456.1 phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 isoform 2
NM_175732.3 NP_783859.1 phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 isoform 1

PTPMT1 Protein Structure

DSPc

DSPc: Dual specificity phosphatase, catalytic domain (63 - 184)

  • 0
  • 100
  • 201 a.a.
Protein Preferred Names Protein Names

phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

NB4 apoptosis/differentiation related protein

Recombinant PTPMT1 Proteins

Cat. No. Product Name Accession Purity
HY-P76556 PTPMT1 Protein, Human (His) Q8WUK0-1 (K28-T201) ≥95%

Related Diseases

Diseases Alias
Mitochondrial Complex Ii Deficiency

Isolated Mitochondrial Respiratory Chain Complex Ii Deficiency

Isolated Succinate-Coenzyme Q Reductase Deficiency

Isolated Succinate-Coq Reductase Deficiency

Isolated Succinate-Ubiquinone Reductase Deficiency

Mitochondrial Respiratory Chain Complex Ii Deficiency

Complex 2 Mitochondrial Respiratory Chain Deficiency

Succinate Coq Reductase Deficiency

Succinate Dehydrogenase Deficiency

Isolated Succinate Dehydrogenase Deficiency

Succinate-Coenzyme Q Reductase Deficiency

Barth Syndrome

3-Methylglutaconic Aciduria Type 2

BTHS

Cardioskeletal Myopathy With Neutropenia And Abnormal Mitochondria

Mga Type Ii

Mga2

Mgca2

Mga Type 2

3-Methylglutaconic Aciduria Type Ii

3-Methylglutaconic Aciduria, Type Ii

Mga, Type Ii

3-Methylglutaconicaciduria Type 2

3-Methylglutaconicaciduria Type Ii

Taz Defect

3 Methylglutaconic Aciduria, Type Ii

Dnajc19 Defect

Cardioskeletal Myopathy-Neutropenia Syndrome

X-Linked Cardioskeletal Myopathy And Neutropenia

3-Alpha-Methylglutaconic Aciduria Type 2

Agm2

Cardioskeletal Myopathy-Neutropenia

Invm

Left Ventricular Non-Compaction Isolated X-Linked

Non-Compaction Of Left Ventricular Myocardium Isolated X-Linked

Agammaglobulinemia 2, Autosomal Recessive

Myopathy, Centronuclear, X-Linked

X-Linked Myotubular Myopathy

Xlmtm

X-Linked Centronuclear Myopathy

Xlcnm

CNMX

Mtm1

Myotubular Myopathy, X-Linked

Mtmx

Myotubular Myopathy 1

Centronuclear Myopathy X-Linked

Myotubular Myopathy

Mtm

Cnm

Xmtm

Myotubular Myopathy Type 1

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Canis familiaris PTPMT1 VGNC VGNC:45166
Rattus norvegicus PTPMT1 RGD RGD:1589783
Macaca mulatta PTPMT1 VGNC VGNC:110527
Bos taurus PTPMT1 VGNC VGNC:33528
Mus musculus PTPMT1 MGD MGI:1913711
Others PTPMT1 NCBI