2. Gene
  3. PTPMT1 - protein tyrosine phosphatase mitochondrial 1 Gene

PTPMT1 - protein tyrosine phosphatase mitochondrial 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MOSP; PLIP; DUSP23; PNAS-129

Gene ID: 114971 | Gene type: protein coding

About PTPMT1

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:47,565,599-47,573,461 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 173 orthologues and 30 paralogues. Ubiquitous expression in testis (RPKM 16.1), brain (RPKM 11.9) and 25 other tissues.

Summary

Predicted to enable phosphatidylglycerophosphatase activity and phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Involved in regulation of intrinsic apoptotic signaling pathway. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

PTPMT1 Products(2)

mRNA Protein Name
NM_001143984.2 NP_001137456.1 phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 isoform 2
NM_175732.3 NP_783859.1 phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
21516116 GOA
Biological Process GO Annotation Evidence Reference Source
involved in regulation of intrinsic apoptotic signaling pathway IGI
IGI: Inferred from genetic interaction
24709986 GOA
Cellular Component GO Annotation Evidence Reference Source
is active in mitochondrion IDA
IDA: Inferred from direct assay
38322995 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPMT1 Protein Structure

DSPc

DSPc: Dual specificity phosphatase, catalytic domain (63 - 184)

  • 0
  • 100
  • 201 a.a.
Protein Preferred Names Protein Names

phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

NB4 apoptosis/differentiation related protein

PTPMT1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PTPMT1 Q8WUK0 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
25416956
Intra
PTPMT1 Q8WUK0 KRT40 Homo sapiens Q6A162
Y2H Array
25416956
Intra
PTPMT1 Q8WUK0 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra
PTPMT1 Q8WUK0 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra
PTPMT1 Q8WUK0 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
25416956
Intra
PTPMT1 Q8WUK0 KRTAP10-9 Homo sapiens P60411
Y2H Array
32296183
Intra
PTPMT1 Q8WUK0 KRTAP10-9 Homo sapiens P60411
Y2H Prey Pooling
32296183
Intra
PTPMT1 Q8WUK0 KRTAP10-7 Homo sapiens P60409
Y2H Prey Pooling
32296183
Intra
PTPMT1 Q8WUK0 KRTAP10-7 Homo sapiens P60409
Validated Y2H
25416956
Intra
PTPMT1 Q8WUK0 KRTAP10-7 Homo sapiens P60409
Y2H Array
32296183
Intra
PTPMT1 Q8WUK0 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Array
32296183
Intra
PTPMT1 Q8WUK0 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Prey Pooling
32296183
Intra
PTPMT1 Q8WUK0 RGS20 Homo sapiens O76081-6
Y2H Prey Pooling
32296183
Intra
PTPMT1 Q8WUK0 RGS20 Homo sapiens O76081-6
Validated Y2H
25416956
Intra
PTPMT1 Q8WUK0 RGS20 Homo sapiens O76081-6
Y2H Array
32296183
Intra
PTPMT1 Q8WUK0 RGS20 Homo sapiens O76081-6
Y2H Array
25416956
Intra
PTPMT1 Q8WUK0 KRTAP2-3 Homo sapiens P0C7H8
Y2H Array
25416956
Intra
PTPMT1 Q8WUK0 KRTAP2-3 Homo sapiens P0C7H8
Validated Y2H
25416956
Intra
PTPMT1 Q8WUK0 KRTAP9-3 Homo sapiens Q9BYQ3
Y2H Array
32296183
Intra
PTPMT1 Q8WUK0 KRTAP9-3 Homo sapiens Q9BYQ3
Y2H Prey Pooling
32296183
Intra
PTPMT1 Q8WUK0 KRTAP9-3 Homo sapiens Q9BYQ3
Validated Y2H
32296183
Intra
PTPMT1 Q8WUK0 KRTAP9-2 Homo sapiens Q9BYQ4
Y2H Prey Pooling
32296183
Intra
PTPMT1 Q8WUK0 KRTAP9-2 Homo sapiens Q9BYQ4
Y2H Array
25416956
Intra
PTPMT1 Q8WUK0 KRTAP9-2 Homo sapiens Q9BYQ4
Y2H Array
32296183
Intra
PTPMT1 Q8WUK0 KRTAP9-2 Homo sapiens Q9BYQ4
Validated Y2H
32296183
Intra
PTPMT1 Q8WUK0 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra
PTPMT1 Q8WUK0 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra
PTPMT1 Q8WUK0 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
Intra
PTPMT1 Q8WUK0 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
Intra
PTPMT1 Q8WUK0 KRTAP12-3 Homo sapiens P60328
Y2H Prey Pooling
32296183
Intra
PTPMT1 Q8WUK0 KRTAP12-3 Homo sapiens P60328
Y2H Array
32296183
Intra
PTPMT1 Q8WUK0 LCE2C Homo sapiens Q5TA81
Y2H Array
32296183
Intra
PTPMT1 Q8WUK0 LCE2C Homo sapiens Q5TA81
Y2H Prey Pooling
32296183
Intra
PTPMT1 Q8WUK0 KRTAP5-7 Homo sapiens Q6L8G8
Y2H Prey Pooling
32296183
Intra
PTPMT1 Q8WUK0 KRTAP5-7 Homo sapiens Q6L8G8
Y2H Array
32296183
Intra
PTPMT1 Q8WUK0 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra
PTPMT1 Q8WUK0 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra
PTPMT1 Q8WUK0 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
PTPMT1 Q8WUK0 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
PTPMT1 Q8WUK0 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
25416956
Intra
PTPMT1 Q8WUK0 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
32296183
Intra
PTPMT1 Q8WUK0 KRTAP5-9 Homo sapiens P26371
Y2H Array
25416956
Intra
PTPMT1 Q8WUK0 KRTAP5-9 Homo sapiens P26371
Y2H Array
32296183
Intra
PTPMT1 Q8WUK0 KRTAP5-9 Homo sapiens P26371
Validated Y2H
25416956
Intra
PTPMT1 Q8WUK0 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
25416956
Intra
PTPMT1 Q8WUK0 TRIM27 Homo sapiens P14373
Validated Y2H
25416956
Intra
PTPMT1 Q8WUK0 TRIM27 Homo sapiens P14373
Y2H Array
25416956
Intra
PTPMT1 Q8WUK0 MDFI Homo sapiens Q99750
Y2H Prey Pooling
25416956
Intra
PTPMT1 Q8WUK0 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra
PTPMT1 Q8WUK0 MDFI Homo sapiens Q99750
Validated Y2H
25416956
Intra
PTPMT1 Q8WUK0 MDFI Homo sapiens Q99750
Validated Y2H
32296183
Intra
PTPMT1 Q8WUK0 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra
PTPMT1 Q8WUK0 MDFI Homo sapiens Q99750
Y2H
21516116
Intra
PTPMT1 Q8WUK0 KRTAP4-12 Homo sapiens Q9BQ66
Validated Y2H
32296183
Intra
PTPMT1 Q8WUK0 KRTAP4-12 Homo sapiens Q9BQ66
Y2H Array
32296183
Intra
PTPMT1 Q8WUK0 KRTAP4-12 Homo sapiens Q9BQ66
Y2H Prey Pooling
32296183
Intra
PTPMT1 Q8WUK0 MTUS2 Homo sapiens Q5JR59
Validated Y2H
25416956
Intra
PTPMT1 Q8WUK0 GRN Homo sapiens P28799
Y2H Prey Pooling
32296183
Intra
PTPMT1 Q8WUK0 GRN Homo sapiens P28799
Y2H Array
32296183
Intra
PTPMT1 Q8WUK0 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra
PTPMT1 Q8WUK0 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra
PTPMT1 Q8WUK0 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Intra
PTPMT1 Q8WUK0 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Prey Pooling
25416956
Intra
PTPMT1 Q8WUK0 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
25416956
Intra
PTPMT1 Q8WUK0 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra
PTPMT1 Q8WUK0 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra
PTPMT1 Q8WUK0 KRT31 Homo sapiens Q15323
Validated Y2H
25416956
Intra
PTPMT1 Q8WUK0 KRTAP3-1 Homo sapiens Q9BYR8
Validated Y2H
32296183
Intra
PTPMT1 Q8WUK0 KRTAP3-1 Homo sapiens Q9BYR8
Y2H Prey Pooling
32296183
Intra
PTPMT1 Q8WUK0 KRTAP3-1 Homo sapiens Q9BYR8
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PTPMT1 Proteins

Cat. No. Product Name Accession Purity
HY-P76556 PTPMT1 Protein, Human (His) Q8WUK0-1 (K28-T201) ≥95%

Related Diseases

Diseases Alias
Mitochondrial Complex Ii Deficiency

Isolated Mitochondrial Respiratory Chain Complex Ii Deficiency

Isolated Succinate-Coenzyme Q Reductase Deficiency

Isolated Succinate-Coq Reductase Deficiency

Isolated Succinate-Ubiquinone Reductase Deficiency

Mitochondrial Respiratory Chain Complex Ii Deficiency

Complex 2 Mitochondrial Respiratory Chain Deficiency

Succinate Coq Reductase Deficiency

Succinate Dehydrogenase Deficiency

Isolated Succinate Dehydrogenase Deficiency

Succinate-Coenzyme Q Reductase Deficiency
Barth Syndrome

3-Methylglutaconic Aciduria Type 2

BTHS

Cardioskeletal Myopathy With Neutropenia And Abnormal Mitochondria

Mga Type Ii

Mga2

Mgca2

Mga Type 2

3-Methylglutaconic Aciduria Type Ii

3-Methylglutaconic Aciduria, Type Ii

Mga, Type Ii

3-Methylglutaconicaciduria Type 2

3-Methylglutaconicaciduria Type Ii

Taz Defect

3 Methylglutaconic Aciduria, Type Ii

Dnajc19 Defect

Cardioskeletal Myopathy-Neutropenia Syndrome

X-Linked Cardioskeletal Myopathy And Neutropenia

3-Alpha-Methylglutaconic Aciduria Type 2

Agm2

Cardioskeletal Myopathy-Neutropenia

Invm

Left Ventricular Non-Compaction Isolated X-Linked

Non-Compaction Of Left Ventricular Myocardium Isolated X-Linked

Agammaglobulinemia 2, Autosomal Recessive
Myopathy, Centronuclear, X-Linked

X-Linked Myotubular Myopathy

Xlmtm

X-Linked Centronuclear Myopathy

Xlcnm

CNMX

Mtm1

Myotubular Myopathy, X-Linked

Mtmx

Myotubular Myopathy 1

Centronuclear Myopathy X-Linked

Myotubular Myopathy

Mtm

Cnm

Xmtm

Myotubular Myopathy Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-108547 Alexidine dihydrochloride 99.59% Unkown
HY-B1474 Alexidine Inhibitor / Unkown
HY-RS11414 PTPMT1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PTPMT1 VGNC VGNC:45166
Rattus norvegicus PTPMT1 RGD RGD:1589783
Macaca mulatta PTPMT1 VGNC VGNC:110527
Bos taurus PTPMT1 VGNC VGNC:33528
Mus musculus PTPMT1 MGD MGI:1913711
Others PTPMT1 NCBI