UHRF2 - ubiquitin like with PHD and ring finger domains 2 Gene

Homo sapiens

Also known as NIRF; URF2; RNF107; TDRD23

Gene ID: 115426 | Gene type: protein coding

About UHRF2

Cytogenetic location: 9p24.1 Genomic coordinates (GRCh38): 9:6,413,199-6,507,054 (from NCBI)

This gene has 13 transcripts (splice variants), 206 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 16.7), lymph node (RPKM 12.5) and 25 other tissues.

Summary

This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding. [provided by RefSeq, Feb 2012]

UHRF2 Products(1)

mRNA	Protein	Name
NM_152896.3	NP_690856.1	E3 ubiquitin-protein ligase UHRF2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	27129234	GOA
enables SUMO transferase activity	EXP EXP: Inferred from Experiment	22467880	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12176013	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	14741369	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	14741369	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell differentiation	IEP IEP: Inferred from expression pattern	12176013	GOA
involved in protein autoubiquitination	IDA IDA: Inferred from direct assay	14741369	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	14741369	GOA
involved in regulation of cell cycle	IDA IDA: Inferred from direct assay	15178429	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	12176013	GOA
located in pericentric heterochromatin	IDA IDA: Inferred from direct assay	27129234	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UHRF2 Protein Structure

ubiquitin

TTD

PHD

SAD_SRA

0
200
400
600
802 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase UHRF2

Np95-like ring finger protein

UHRF2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	UHRF2	Q96PU4	CCND1	Homo sapiens	P24385	Anti Tag CoIP	21952639
Intra	UHRF2	Q96PU4	CCND1	Homo sapiens	P24385	Pull Down	21952639
Intra	UHRF2	Q96PU4	CDK2	Homo sapiens	P24941	Protein Kinase Assay	15178429
Intra	UHRF2	Q96PU4	CDK2	Homo sapiens	P24941	Anti Bait CoIP	15178429
Intra	UHRF2	Q96PU4	CDK2	Homo sapiens	P24941	Pull Down	15178429
Intra	UHRF2	Q96PU4	CCNA2	Homo sapiens	P20248	Anti Tag CoIP	21952639
Intra	UHRF2	Q96PU4	RB1	Homo sapiens	P06400	Pull Down	21952639
Intra	UHRF2	Q96PU4	RB1	Homo sapiens	P06400	Antibody Array	21952639
Intra	UHRF2	Q96PU4	RB1	Homo sapiens	P06400	Anti Tag CoIP	21952639
Intra	UHRF2	Q96PU4	CCNB1	Homo sapiens	P14635	Anti Tag CoIP	21952639
Intra	UHRF2	Q96PU4	CCNE1	Homo sapiens	P24864	Pull Down	21952639
Intra	UHRF2	Q96PU4	CCNE1	Homo sapiens	P24864	Ubiquitinase Assay	21952639
Intra	UHRF2	Q96PU4	CCNE1	Homo sapiens	P24864	Anti Tag CoIP	21952639

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15446	UHRF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	UHRF2	VGNC	VGNC:54508
Canis familiaris	UHRF2	VGNC	VGNC:48126
Rattus norvegicus	UHRF2	RGD	RGD:1309990
Macaca mulatta	UHRF2	VGNC	VGNC:78714
Felis catus	UHRF2	VGNC	VGNC:66812
Mus musculus	UHRF2	MGD	MGI:1923718
Others	UHRF2	NCBI

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