NOSTRIN - nitric oxide synthase trafficking Gene

Homo sapiens

Also known as DaIP2

Gene ID: 115677 | Gene type: protein coding

About NOSTRIN

Cytogenetic location: 2q24.3 Genomic coordinates (GRCh38): 2:168,786,539-168,865,514 (from NCBI)

This gene has 13 transcripts (splice variants), 1 gene allele, 176 orthologues and 3 paralogues. Ubiquitous expression in fat (RPKM 8.2), lung (RPKM 6.6) and 24 other tissues.

Summary

Nitric oxide (NO) is a potent mediator in biologic processes such as neurotransmission, inflammatory response, and vascular homeostasis. NOSTRIN binds the Enzyme responsible for NO production, endothelial NO Synthase (ENOS; MIM 163729), and triggers the translocation of eNOS from the plasma membrane to vesicle-like subcellular structures, thereby attenuating ENOS-dependent NO production.[supplied by OMIM, Apr 2004]

NOSTRIN Products(4)

mRNA	Protein	Name
NM_001039724.4	NP_001034813.2	nostrin isoform 2
NM_001171631.2	NP_001165102.1	nostrin isoform 4
NM_001171632.2	NP_001165103.1	nostrin isoform 3
NM_052946.4	NP_443178.2	nostrin isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12446846	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NOSTRIN Protein Structure

FCH

SH3_1

0
100
200
300
400
506 a.a.

Protein Preferred Names

Protein Names

nostrin

BM247 homolog

Related Diseases

Diseases

Alias

Eclampsia

Eclampsia In Puerperium	Postpartum Eclampsia
Eclampsia, Postpartum	Puerperal Eclampsia

Pre-Eclampsia

Preeclampsia	Gestational Hypertension
Hypertension Induced By Pregnancy	Pre-Eclamptic Toxaemia
Pregnancy Associated Hypertension	Proteinuric Hypertension Of Pregnancy
Hypertension, Pregnancy-Induced, Susceptibility To	Preeclampsia/Eclampsia
Pregnancy Toxemia	Toxaemia Of Pregnancy
Gestational Proteinuric Hypertension	Pregnancy-Induced Hypertension
Toxemia Of Pregnancy	Preeclampsia, Susceptibility To
Transient Hypertension Of Pregnancy	Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria
Gestational Hypertension Nos	Mild Proteinuric Hypertension Of Pregnancy
Pih - [Pregnancy-Induced Hypertension]	Pregnancy-Induced Hypertension Nos
Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria	Pe - [Pre-Eclampsia]
Pre-Eclampsia Nos	Pre-Eclamptic Nos
Pregnancy Pre-Eclampsia	Puerperal Pre-Eclampsia
Pre-Eclampsia Toxaemia	Toxaemia In Pregnancy
Pet - [Pre-Eclamptic Toxaemia]	Maternal Toxaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09444	NOSTRIN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NOSTRIN	MGD	MGI:3606242
Canis familiaris	NOSTRIN	VGNC	VGNC:43897
Rattus norvegicus	NOSTRIN	RGD	RGD:727920
Macaca mulatta	NOSTRIN	VGNC	VGNC:75219
Bos taurus	NOSTRIN	VGNC	VGNC:32176
Felis catus	NOSTRIN	VGNC	VGNC:63862

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