2. Gene
  3. DHRS1 - dehydrogenase/reductase 1 Gene

DHRS1 - dehydrogenase/reductase 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SDR19C1

Gene ID: 115817 | Gene type: protein coding

About DHRS1

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:24,290,598-24,299,780 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele, 197 orthologues and 13 paralogues. Ubiquitous expression in liver (RPKM 39.6), esophagus (RPKM 38.5) and 24 other tissues.

Summary

This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family. The encoded Enzyme contains a conserved catalytic domain and likely functions as an oxidoreductase. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008]

DHRS1 Products(2)

mRNA Protein Name
NM_001136050.3 NP_001129522.1 dehydrogenase/reductase SDR family member 1
NM_138452.3 NP_612461.1 dehydrogenase/reductase SDR family member 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables carbonyl reductase (NADPH) activity IDA
IDA: Inferred from direct assay
30031147 GOA
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IDA
IDA: Inferred from direct assay
30031147 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DHRS1 Protein Structure

adh_short

adh_short: short chain dehydrogenase (9 - 181)

  • 0
  • 100
  • 200
  • 313 a.a.
Protein Preferred Names Protein Names

dehydrogenase/reductase SDR family member 1

dehydrogenase/reductase (SDR family) member 1

DHRS1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
DHRS1 Q96LJ7 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra
DHRS1 Q96LJ7 KRTAP10-8 Homo sapiens P60410
Validated Y2H
25416956
Intra
DHRS1 Q96LJ7 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra
DHRS1 Q96LJ7 KRTAP10-9 Homo sapiens P60411
Y2H Prey Pooling
32296183
Intra
DHRS1 Q96LJ7 KRTAP10-9 Homo sapiens P60411
Y2H Array
32296183
Intra
DHRS1 Q96LJ7 KRTAP12-2 Homo sapiens P59991
Y2H Array
32296183
Intra
DHRS1 Q96LJ7 KRTAP12-2 Homo sapiens P59991
Y2H Prey Pooling
32296183
Intra
DHRS1 Q96LJ7 KRTAP12-1 Homo sapiens P59990
Y2H Prey Pooling
32296183
Intra
DHRS1 Q96LJ7 KRTAP12-1 Homo sapiens P59990
Y2H Array
32296183
Intra
DHRS1 Q96LJ7 KRTAP4-11 Homo sapiens Q9BYQ6
Y2H Prey Pooling
32296183
Intra
DHRS1 Q96LJ7 KRTAP4-11 Homo sapiens Q9BYQ6
Validated Y2H
32296183
Intra
DHRS1 Q96LJ7 KRTAP4-11 Homo sapiens Q9BYQ6
Y2H Array
32296183
Intra
DHRS1 Q96LJ7 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra
DHRS1 Q96LJ7 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra
DHRS1 Q96LJ7 KRTAP11-1 Homo sapiens Q8IUC1
Y2H Array
32296183
Intra
DHRS1 Q96LJ7 KRTAP11-1 Homo sapiens Q8IUC1
Y2H Prey Pooling
32296183
Intra
DHRS1 Q96LJ7 LCE2B Homo sapiens O14633
Y2H Array
32296183
Intra
DHRS1 Q96LJ7 LCE2B Homo sapiens O14633
Y2H Prey Pooling
32296183
Intra
DHRS1 Q96LJ7 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra
DHRS1 Q96LJ7 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra
DHRS1 Q96LJ7 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
Intra
DHRS1 Q96LJ7 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
Intra
DHRS1 Q96LJ7 KRTAP12-3 Homo sapiens P60328
Y2H Prey Pooling
32296183
Intra
DHRS1 Q96LJ7 KRTAP12-3 Homo sapiens P60328
Y2H Array
32296183
Intra
DHRS1 Q96LJ7 KRTAP5-2 Homo sapiens Q701N4
Y2H Array
32296183
Intra
DHRS1 Q96LJ7 KRTAP5-2 Homo sapiens Q701N4
Y2H Prey Pooling
32296183
Intra
DHRS1 Q96LJ7 KRTAP9-8 Homo sapiens Q9BYQ0
Validated Y2H
32296183
Intra
DHRS1 Q96LJ7 KRTAP9-8 Homo sapiens Q9BYQ0
Y2H Prey Pooling
32296183
Intra
DHRS1 Q96LJ7 KRTAP9-8 Homo sapiens Q9BYQ0
Y2H Array
32296183
Intra
DHRS1 Q96LJ7 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra
DHRS1 Q96LJ7 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra
DHRS1 Q96LJ7 KRTAP6-2 Homo sapiens Q3LI66
Y2H Array
32296183
Intra
DHRS1 Q96LJ7 KRTAP6-2 Homo sapiens Q3LI66
Y2H Prey Pooling
32296183
Intra
DHRS1 Q96LJ7 KRTAP5-1 Homo sapiens Q6L8H4
Y2H Prey Pooling
32296183
Intra
DHRS1 Q96LJ7 KRTAP5-1 Homo sapiens Q6L8H4
Y2H Array
32296183
Intra
DHRS1 Q96LJ7 LAMP2 Homo sapiens P13473-2
Y2H Pooling
32814053
Intra
DHRS1 Q96LJ7 LAMP2 Homo sapiens P13473-2
Validated Y2H
32814053
Intra
DHRS1 Q96LJ7 LAMP2 Homo sapiens P13473-2
Y2H Array
32814053
Intra
DHRS1 Q96LJ7 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra
DHRS1 Q96LJ7 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra
DHRS1 Q96LJ7 KRTAP6-3 Homo sapiens Q3LI67
Y2H Prey Pooling
32296183
Intra
DHRS1 Q96LJ7 KRTAP6-3 Homo sapiens Q3LI67
Y2H Array
32296183
Intra
DHRS1 Q96LJ7 SH3GLB1 Homo sapiens Q9Y371
Validated Y2H
32814053
Intra
DHRS1 Q96LJ7 SH3GLB1 Homo sapiens Q9Y371
Y2H Pooling
32814053
Intra
DHRS1 Q96LJ7 SH3GLB1 Homo sapiens Q9Y371
Y2H Array
32814053
Intra
DHRS1 Q96LJ7 LHX4 Homo sapiens Q969G2
Y2H Prey Pooling
32296183
Intra
DHRS1 Q96LJ7 LHX4 Homo sapiens Q969G2
Y2H Array
32296183
Intra
DHRS1 Q96LJ7 KRTAP4-1 Homo sapiens Q9BYQ7
Y2H Array
32296183
Intra
DHRS1 Q96LJ7 KRTAP4-1 Homo sapiens Q9BYQ7
Y2H Prey Pooling
32296183
Intra
DHRS1 Q96LJ7 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
25416956
Intra
DHRS1 Q96LJ7 DIABLO Homo sapiens Q9NR28
Validated Y2H
32296183
Intra
DHRS1 Q96LJ7 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra
DHRS1 Q96LJ7 MDFI Homo sapiens Q99750
Validated Y2H
32296183
Intra
DHRS1 Q96LJ7 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra
DHRS1 Q96LJ7 KRTAP3-2 Homo sapiens Q9BYR7
Y2H Prey Pooling
25416956
Intra
DHRS1 Q96LJ7 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
25416956
Intra
DHRS1 Q96LJ7 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Nevus, Epidermal

Epidermal Nevus

Woolly Hair Nevus

Epidermal Naevus

Epidermal Nevus Syndrome

Nevus, Keratinocytic, Nonepidermolytic

Epidermal Nevus, Somatic

Nevus, Epidermal, Somatic

Nevus Sebaceous Or Woolly Hair Nevus, Somatic

Nonepidermolytic Keratinocytic Nevus

Epidermal Hamartoma Syndrome

Wooly Hair Nevus

Keratinocytic Non-Epidermolytic Nevus

KNEN

Pigmented Moles

Organoid Nevus Phakomatosis

Nevus Sebaceous

Melanocytic Nevus

Melanocytic Nevus Of Skin
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03738 DHRS1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus DHRS1 RGD RGD:1359172
Mus musculus DHRS1 MGD MGI:1196314
Canis familiaris DHRS1 VGNC VGNC:56058
Bos taurus DHRS1 VGNC VGNC:28039
Macaca mulatta DHRS1 VGNC VGNC:71629
Felis catus DHRS1 VGNC VGNC:61468
Others DHRS1 NCBI