2. Gene
  3. TGM7 - transglutaminase 7 Gene

TGM7 - transglutaminase 7 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TGMZ

Gene ID: 116179 | Gene type: protein coding

About TGM7

Cytogenetic location: 15q15.2-q15.3 Genomic coordinates (GRCh38): 15:43,276,271-43,302,255 (from NCBI)

This gene has 2 transcripts (splice variants), 121 orthologues and 8 paralogues. Low expression observed in reference dataset.

Summary

Transglutaminases (TGM; EC 2.3.2.13) are a family of structurally and functionally related Enzymes that stabilize protein assemblies through the formation of gamma-glutamyl-epsilon lysine crosslinks. For additional background information on transglutaminases, see TGM1 (MIM 190195).[supplied by OMIM, Jul 2002]

TGM7 Products(1)

mRNA Protein Name
NM_052955.3 NP_443187.1 protein-glutamine gamma-glutamyltransferase Z
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TGM7 Protein Structure

Transglut_N

Transglut_N: Transglutaminase family (7 - 124)

Transglut_core

Transglut_core: Transglutaminase-like superfamily (275 - 362)

Transglut_C

Transglut_C: Transglutaminase family, C-terminal ig like domain (608 - 705)

  • 0
  • 200
  • 400
  • 600
  • 710 a.a.
Protein Preferred Names Protein Names

protein-glutamine gamma-glutamyltransferase Z

TG(Z)

Related Diseases

Diseases Alias
Retinal Lattice Degeneration

Palisade Degeneration Of Retina

Lattice Retinal Degeneration
Richter'S Syndrome

Richter Syndrome

Richter Transformation
Gingival Fibromatosis

Hereditary Gingival Fibromatosis

Hereditary Gingival Hyperplasia

Autosomal Dominant Gingival Fibromatosis

Autosomal Dominant Gingival Hyperplasia

Fibromatosis, Gingival, Hereditary

Fibromatosis, Gingival
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14464 TGM7 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TGM7 RGD RGD:7615199
Canis familiaris TGM7 VGNC VGNC:47320
Felis catus TGM7 VGNC VGNC:66145
Mus musculus TGM7 MGD MGI:2151164
Bos taurus TGM7 VGNC VGNC:35814
Macaca mulatta TGM7 VGNC VGNC:79880