TGM7 - transglutaminase 7 Gene

Homo sapiens

Also known as TGMZ

Gene ID: 116179 | Gene type: protein coding

About TGM7

Cytogenetic location: 15q15.2-q15.3 Genomic coordinates (GRCh38): 15:43,276,271-43,302,255 (from NCBI)

This gene has 2 transcripts (splice variants), 121 orthologues and 8 paralogues. Low expression observed in reference dataset.

Summary

Transglutaminases (TGM; EC 2.3.2.13) are a family of structurally and functionally related Enzymes that stabilize protein assemblies through the formation of gamma-glutamyl-epsilon lysine crosslinks. For additional background information on transglutaminases, see TGM1 (MIM 190195).[supplied by OMIM, Jul 2002]

TGM7 Products(1)

mRNA	Protein	Name
NM_052955.3	NP_443187.1	protein-glutamine gamma-glutamyltransferase Z

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TGM7 Protein Structure

Transglut_N

Transglut_core

Transglut_C

0
200
400
600
710 a.a.

Protein Preferred Names

Protein Names

protein-glutamine gamma-glutamyltransferase Z

TG(Z)

TGM7 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TGM7	Q96PF1	LAMTOR3	Homo sapiens	Q9UHA4	Validated Y2H	32296183
Intra	TGM7	Q96PF1	KRT39	Homo sapiens	Q6A163	Y2H Prey Pooling	32296183
Intra	TGM7	Q96PF1	KRT39	Homo sapiens	Q6A163	Y2H Array	32296183
Intra	TGM7	Q96PF1	UNKL	Homo sapiens	Q9H9P5-5	Validated Y2H	32296183
Intra	TGM7	Q96PF1	UNKL	Homo sapiens	Q9H9P5-5	Y2H Array	32296183
Intra	TGM7	Q96PF1	UNKL	Homo sapiens	Q9H9P5-5	Y2H Prey Pooling	32296183
Intra	TGM7	Q96PF1	a0a1u9x8x8_human	Homo sapiens	A0A1U9X8X8	Y2H Prey Pooling	32296183
Intra	TGM7	Q96PF1	a0a1u9x8x8_human	Homo sapiens	A0A1U9X8X8	Y2H Array	32296183
Intra	TGM7	Q96PF1	SDS	Homo sapiens	P20132	Y2H Prey Pooling	32296183
Intra	TGM7	Q96PF1	SDS	Homo sapiens	P20132	Y2H Array	32296183
Intra	TGM7	Q96PF1	SPRY1	Homo sapiens	O43609	Y2H Array	32296183
Intra	TGM7	Q96PF1	SPRY1	Homo sapiens	O43609	Y2H Prey Pooling	32296183
Intra	TGM7	Q96PF1	TSSK3	Homo sapiens	Q96PN8	Validated Y2H	32296183
Intra	TGM7	Q96PF1	PPCDC	Homo sapiens	Q96CD2	Y2H Prey Pooling	32296183
Intra	TGM7	Q96PF1	PPCDC	Homo sapiens	Q96CD2	Y2H Array	32296183
Intra	TGM7	Q96PF1	HOXA1	Homo sapiens	P49639	Y2H Prey Pooling	32296183
Intra	TGM7	Q96PF1	HOXA1	Homo sapiens	P49639	Y2H Array	32296183
Intra	TGM7	Q96PF1	KCTD1	Homo sapiens	Q719H9	Y2H Array	32296183
Intra	TGM7	Q96PF1	KCTD1	Homo sapiens	Q719H9	Y2H Prey Pooling	32296183
Intra	TGM7	Q96PF1	ARID5A	Homo sapiens	Q03989	Y2H Array	32296183
Intra	TGM7	Q96PF1	ARID5A	Homo sapiens	Q03989	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Retinal Lattice Degeneration

Palisade Degeneration Of Retina

Lattice Retinal Degeneration

Richter'S Syndrome

Richter Syndrome

Richter Transformation

Gingival Fibromatosis

Hereditary Gingival Fibromatosis	Hereditary Gingival Hyperplasia
Autosomal Dominant Gingival Fibromatosis	Autosomal Dominant Gingival Hyperplasia
Fibromatosis, Gingival, Hereditary	Fibromatosis, Gingival

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14464	TGM7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TGM7	RGD	RGD:7615199
Canis familiaris	TGM7	VGNC	VGNC:47320
Felis catus	TGM7	VGNC	VGNC:66145
Mus musculus	TGM7	MGD	MGI:2151164
Bos taurus	TGM7	VGNC	VGNC:35814
Macaca mulatta	TGM7	VGNC	VGNC:79880

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