1. Gene
  2. SPRY1 - sprouty RTK signaling antagonist 1 Gene

SPRY1 - sprouty RTK signaling antagonist 1 Gene

Homo sapiens

Also known as hSPRY1

Gene ID: 10252 | Gene type: protein coding

About SPRY1

Cytogenetic location: 4q28.1 Genomic coordinates (GRCh38): 4:123,396,795-123,403,760 (from NCBI)

This gene has 9 transcripts (splice variants), 188 orthologues and 3 paralogues. Ubiquitous expression in fat (RPKM 30.2), gall bladder (RPKM 30.0) and 25 other tissues.

Summary

Involved in negative regulation of Fibroblast Growth Factor receptor signaling pathway. Located in Golgi apparatus; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

SPRY1 Products(5)

mRNA Protein Name
NM_001258038.2 NP_001244967.1 protein sprouty homolog 1
NM_001258039.1 NP_001244968.1 protein sprouty homolog 1
NM_001375410.1 NP_001362339.1 protein sprouty homolog 1
NM_005841.3 NP_005832.1 protein sprouty homolog 1
NM_199327.3 NP_955359.1 protein sprouty homolog 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
21988832 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of fibroblast growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
16481357 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPRY1 Protein Structure

Sprouty

Sprouty: Sprouty protein (Spry) (186 - 298)

  • 0
  • 100
  • 200
  • 300
  • 319 a.a.
Protein Preferred Names Protein Names

protein sprouty homolog 1

sprouty homolog 1, antagonist of FGF signaling

SPRY1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SPRY1 O43609 KRTAP10-8 Homo sapiens P60410 32296183
Intra
SPRY1 O43609 KRTAP10-8 Homo sapiens P60410 25416956
Intra
SPRY1 O43609 KRTAP10-8 Homo sapiens P60410 32296183
Intra
SPRY1 O43609 KRTAP10-8 Homo sapiens P60410 25416956
Intra
SPRY1 O43609 KRTAP10-8 Homo sapiens P60410 25416956
Intra
SPRY1 O43609 KRTAP10-8 Homo sapiens P60410 32296183
Intra
SPRY1 O43609 KRTAP10-9 Homo sapiens P60411 32296183
Intra
SPRY1 O43609 KRTAP10-9 Homo sapiens P60411 32296183
Intra
SPRY1 O43609 KRTAP10-9 Homo sapiens P60411 25416956
Intra
SPRY1 O43609 KRTAP10-9 Homo sapiens P60411 32296183
Intra
SPRY1 O43609 KRTAP10-5 Homo sapiens P60370 25416956
Intra
SPRY1 O43609 KRTAP10-5 Homo sapiens P60370 25416956
Intra
SPRY1 O43609 KRTAP10-7 Homo sapiens P60409 25416956
Intra
SPRY1 O43609 KRTAP10-7 Homo sapiens P60409 32296183
Intra
SPRY1 O43609 KRTAP10-7 Homo sapiens P60409 25416956
Intra
SPRY1 O43609 KRTAP10-7 Homo sapiens P60409 32296183
Intra
SPRY1 O43609 KRTAP10-7 Homo sapiens P60409 32296183
Intra
SPRY1 O43609 KRTAP4-2 Homo sapiens Q9BYR5 25416956
Intra
SPRY1 O43609 ADAMTSL4 Homo sapiens Q6UY14-3 32296183
Intra
SPRY1 O43609 ADAMTSL4 Homo sapiens Q6UY14-3 32296183
Intra
SPRY1 O43609 ADAMTSL4 Homo sapiens Q6UY14-3 32296183
Intra
SPRY1 O43609 KRTAP12-2 Homo sapiens P59991 32296183
Intra
SPRY1 O43609 KRTAP12-2 Homo sapiens P59991 32296183
Intra
SPRY1 O43609 KRTAP12-2 Homo sapiens P59991 32296183
Intra
SPRY1 O43609 CREB5 Homo sapiens Q02930-3 25416956
Intra
SPRY1 O43609 CREB5 Homo sapiens Q02930-3 32296183
Intra
SPRY1 O43609 CREB5 Homo sapiens Q02930-3 25416956
Intra
SPRY1 O43609 KRTAP10-11 Homo sapiens P60412 32296183
Intra
SPRY1 O43609 LCE3C Homo sapiens Q5T5A8 32296183
Intra
SPRY1 O43609 LCE1B Homo sapiens Q5T7P3 25416956
Intra
SPRY1 O43609 LCE1B Homo sapiens Q5T7P3 25416956
Intra
SPRY1 O43609 LCE4A Homo sapiens Q5TA78 32296183
Intra
SPRY1 O43609 LCE4A Homo sapiens Q5TA78 32296183
Intra
SPRY1 O43609 LCE4A Homo sapiens Q5TA78 32296183
Intra
SPRY1 O43609 LCE2A Homo sapiens Q5TA79 32296183
Intra
SPRY1 O43609 LCE2D Homo sapiens Q5TA82 32296183
Intra
SPRY1 O43609 LCE2D Homo sapiens Q5TA82 25416956
Intra
SPRY1 O43609 R3HDM2 Homo sapiens Q9Y2K5-2 25416956
Intra
SPRY1 O43609 KRTAP9-3 Homo sapiens Q9BYQ3 32296183
Intra
SPRY1 O43609 KRTAP9-2 Homo sapiens Q9BYQ4 32296183
Intra
SPRY1 O43609 KRTAP11-1 Homo sapiens Q8IUC1 32296183
Intra
SPRY1 O43609 KRTAP11-1 Homo sapiens Q8IUC1 32296183
Intra
SPRY1 O43609 KRTAP11-1 Homo sapiens Q8IUC1 32296183
Intra
SPRY1 O43609 PRKAB2 Homo sapiens O43741 32296183
Intra
SPRY1 O43609 REL Homo sapiens Q04864-2 32296183
Intra
SPRY1 O43609 REL Homo sapiens Q04864-2 32296183
Intra
SPRY1 O43609 REL Homo sapiens Q04864-2 32296183
Intra
SPRY1 O43609 CCDC57 Homo sapiens Q2TAC2-2 32296183
Intra
SPRY1 O43609 KPRP Homo sapiens Q5T749 32296183
Intra
SPRY1 O43609 KPRP Homo sapiens Q5T749 32296183
Intra
SPRY1 O43609 KPRP Homo sapiens Q5T749 32296183
Intra
SPRY1 O43609 CDR2L Homo sapiens Q86X02 32296183
Intra
SPRY1 O43609 MB21D2 Homo sapiens Q8IYB1 32296183
Intra
SPRY1 O43609 MB21D2 Homo sapiens Q8IYB1 32296183
Intra
SPRY1 O43609 MB21D2 Homo sapiens Q8IYB1 32296183
Intra
SPRY1 O43609 LCE1D Homo sapiens Q5T752 32296183
Intra
SPRY1 O43609 LCE1D Homo sapiens Q5T752 32296183
Intra
SPRY1 O43609 LCE1D Homo sapiens Q5T752 32296183
Intra
SPRY1 O43609 KRTAP1-3 Homo sapiens Q8IUG1 32296183
Intra
SPRY1 O43609 KRTAP1-3 Homo sapiens Q8IUG1 32296183
Intra
SPRY1 O43609 TFAP2D Homo sapiens Q7Z6R9 32296183
Intra
SPRY1 O43609 KRTAP12-3 Homo sapiens P60328 32296183
Intra
SPRY1 O43609 KRTAP12-3 Homo sapiens P60328 32296183
Intra
SPRY1 O43609 KRTAP12-3 Homo sapiens P60328 32296183
Intra
SPRY1 O43609 LCE5A Homo sapiens Q5TCM9 32296183
Intra
SPRY1 O43609 LCE5A Homo sapiens Q5TCM9 32296183
Intra
SPRY1 O43609 LCE5A Homo sapiens Q5TCM9 32296183
Intra
SPRY1 O43609 PCSK5 Homo sapiens Q92824-2 32296183
Intra
SPRY1 O43609 PCSK5 Homo sapiens Q92824-2 32296183
Intra
SPRY1 O43609 PCSK5 Homo sapiens Q92824-2 32296183
Intra
SPRY1 O43609 FBLN1 Homo sapiens P23142-4 32296183
Intra
SPRY1 O43609 VWC2 Homo sapiens Q2TAL6 32296183
Intra
SPRY1 O43609 VWC2 Homo sapiens Q2TAL6 32296183
Intra
SPRY1 O43609 VWC2 Homo sapiens Q2TAL6 32296183
Intra
SPRY1 O43609 LCE1F Homo sapiens Q5T754 32296183
Intra
SPRY1 O43609 LCE1F Homo sapiens Q5T754 32296183
Intra
SPRY1 O43609 LCE1F Homo sapiens Q5T754 32296183
Intra
SPRY1 O43609 KRTAP1-1 Homo sapiens Q07627 32296183
Intra
SPRY1 O43609 KRTAP1-1 Homo sapiens Q07627 32296183
Intra
SPRY1 O43609 KRTAP1-1 Homo sapiens Q07627 32296183
Intra
SPRY1 O43609 LCE1A Homo sapiens Q5T7P2 32296183
Intra
SPRY1 O43609 LCE1A Homo sapiens Q5T7P2 32296183
Intra
SPRY1 O43609 LCE1A Homo sapiens Q5T7P2 32296183
Intra
SPRY1 O43609 ZNF837 Homo sapiens Q96EG3 32296183
Intra
SPRY1 O43609 ZNF837 Homo sapiens Q96EG3 32296183
Intra
SPRY1 O43609 ZNF837 Homo sapiens Q96EG3 32296183
Intra
SPRY1 O43609 LCE2C Homo sapiens Q5TA81 32296183
Intra
SPRY1 O43609 LCE2C Homo sapiens Q5TA81 32296183
Intra
SPRY1 O43609 LCE2C Homo sapiens Q5TA81 32296183
Intra
SPRY1 O43609 GNE Homo sapiens Q9Y223-2 32296183
Intra
SPRY1 O43609 GUCD1 Homo sapiens Q96NT3-2 32296183
Intra
SPRY1 O43609 NTM Homo sapiens Q9P121-3 32296183
Intra
SPRY1 O43609 TGM7 Homo sapiens Q96PF1 32296183
Intra
SPRY1 O43609 LCE1C Homo sapiens Q5T751 32296183
Intra
SPRY1 O43609 LCE1C Homo sapiens Q5T751 32296183
Intra
SPRY1 O43609 LCE1C Homo sapiens Q5T751 32296183
Intra
SPRY1 O43609 PRKAA2 Homo sapiens P54646 32296183
Intra
SPRY1 O43609 MEOX2 Homo sapiens Q6FHY5 32296183
Intra
SPRY1 O43609 MEOX2 Homo sapiens Q6FHY5 32296183
Intra
SPRY1 O43609 MEOX2 Homo sapiens Q6FHY5 32296183
Intra
SPRY1 O43609 ANKRD11 Homo sapiens X5D778 32296183
Intra
SPRY1 O43609 ZNF441 Homo sapiens Q8N8Z8 32296183
Intra
SPRY1 O43609 NOTCH2NLC Homo sapiens P0DPK4 32296183
Intra
SPRY1 O43609 NOTCH2NLC Homo sapiens P0DPK4 32296183
Intra
SPRY1 O43609 NOTCH2NLC Homo sapiens P0DPK4 32296183
Intra
SPRY1 O43609 FARS2 Homo sapiens O95363 32296183
Intra
SPRY1 O43609 GEMIN4 Homo sapiens P57678 32296183
Intra
SPRY1 O43609 GEMIN4 Homo sapiens P57678 32296183
Intra
SPRY1 O43609 GEMIN4 Homo sapiens P57678 32296183
Intra
SPRY1 O43609 ZNF330 Homo sapiens Q9Y3S2 32296183
Intra
SPRY1 O43609 ZNF330 Homo sapiens Q9Y3S2 32296183
Intra
SPRY1 O43609 ZNF330 Homo sapiens Q9Y3S2 32296183
Intra
SPRY1 O43609 CYSRT1 Homo sapiens A8MQ03 32296183
Intra
SPRY1 O43609 CYSRT1 Homo sapiens A8MQ03 32296183
Cross
SPRY1 O43609 Hoxa1 Mus musculus P09022 23088713
Intra
SPRY1 O43609 KRTAP5-9 Homo sapiens P26371 32296183
Intra
SPRY1 O43609 KRTAP5-9 Homo sapiens P26371 32296183
Intra
SPRY1 O43609 KRTAP5-9 Homo sapiens P26371 32296183
Intra
SPRY1 O43609 ZNF23 Homo sapiens P17027 32296183
Intra
SPRY1 O43609 INCA1 Homo sapiens Q0VD86 32296183
Intra
SPRY1 O43609 INCA1 Homo sapiens Q0VD86 32296183
Intra
SPRY1 O43609 INCA1 Homo sapiens Q0VD86 32296183
Intra
SPRY1 O43609 LCE3D Homo sapiens Q9BYE3 32296183
Intra
SPRY1 O43609 HSF2BP Homo sapiens O75031 32296183
Intra
SPRY1 O43609 HSF2BP Homo sapiens O75031 32296183
Intra
SPRY1 O43609 HSF2BP Homo sapiens O75031 32296183
Intra
SPRY1 O43609 MDFI Homo sapiens Q99750 25416956
Intra
SPRY1 O43609 MDFI Homo sapiens Q99750 32296183
Intra
SPRY1 O43609 MDFI Homo sapiens Q99750 32296183
Intra
SPRY1 O43609 MDFI Homo sapiens Q99750 25416956
Intra
SPRY1 O43609 MDFI Homo sapiens Q99750 32296183
Intra
SPRY1 O43609 UBASH3A Homo sapiens P57075-2 32296183
Intra
SPRY1 O43609 KRTAP4-12 Homo sapiens Q9BQ66 32296183
Intra
SPRY1 O43609 OTX1 Homo sapiens P32242 25416956
Intra
SPRY1 O43609 ZNF417 Homo sapiens Q8TAU3 32296183
Intra
SPRY1 O43609 HOXA1 Homo sapiens P49639 32296183
Intra
SPRY1 O43609 HOXA1 Homo sapiens P49639 25416956
Intra
SPRY1 O43609 HOXA1 Homo sapiens P49639 32296183
Intra
SPRY1 O43609 HOXA1 Homo sapiens P49639 25416956
Intra
SPRY1 O43609 HOXA1 Homo sapiens P49639 32296183
Intra
SPRY1 O43609 SPRY2 Homo sapiens O43597 25416956
Intra
SPRY1 O43609 SPRY2 Homo sapiens O43597 25416956
Intra
SPRY1 O43609 MEOX2 Homo sapiens P50222 25416956
Intra
SPRY1 O43609 MEOX2 Homo sapiens P50222 25416956
Intra
SPRY1 O43609 SMCP Homo sapiens P49901 32296183
Intra
SPRY1 O43609 SMCP Homo sapiens P49901 32296183
Intra
SPRY1 O43609 SMCP Homo sapiens P49901 32296183
Intra
SPRY1 O43609 FHL5 Homo sapiens Q5TD97 32296183
Intra
SPRY1 O43609 FHL5 Homo sapiens Q5TD97 32296183
Intra
SPRY1 O43609 FHL5 Homo sapiens Q5TD97 32296183
Intra
SPRY1 O43609 KRTAP3-2 Homo sapiens Q9BYR7 32296183
Intra
SPRY1 O43609 KRTAP3-2 Homo sapiens Q9BYR7 32296183
Intra
SPRY1 O43609 KRTAP3-2 Homo sapiens Q9BYR7 32296183
Intra
SPRY1 O43609 LCE3A Homo sapiens Q5TA76 32296183
Intra
SPRY1 O43609 NOTCH2NLA Homo sapiens Q7Z3S9 25416956
Intra
SPRY1 O43609 NOTCH2NLA Homo sapiens Q7Z3S9 31515488
Intra
SPRY1 O43609 NOTCH2NLA Homo sapiens Q7Z3S9 25416956
Intra
SPRY1 O43609 NOTCH2NLA Homo sapiens Q7Z3S9 25416956
Intra
SPRY1 O43609 CHRD Homo sapiens Q9H2X0 32296183
Intra
SPRY1 O43609 KRT31 Homo sapiens Q15323 32296183
Intra
SPRY1 O43609 KRT31 Homo sapiens Q15323 32296183
Intra
SPRY1 O43609 KRT31 Homo sapiens Q15323 32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Adrenal Cortical Adenocarcinoma

Adrenal Cortex Adenocarcinoma

Adrenocortical Carcinoma

Legius Syndrome

Neurofibromatosis Type 1-Like Syndrome

Nfls

LGSS

Neurofibromatosis 1-Like Syndrome

Neurofibromatosis Type 1 Like Syndrome

Nf1-Like Syndrome

Neurofibromatosis, Type 1-Like Syndrome

Colon Squamous Cell Carcinoma

Colonic Epidermoid Carcinoma

Squamous Cell Carcinoma Of Colon

Squamous Cell Carcinoma Of The Colon

Pulsating Exophthalmos
Noonan Syndrome With Multiple Lentigines

Leopard Syndrome

Multiple Lentigines Syndrome

Moynahan Syndrome

Cardiomyopathic Lentiginosis

Progressive Cardiomyopathic Lentiginosis

Cardio-Cutaneous Syndrome

Lentiginosis Profusa

Capute-Rimoin-Konigsmark-Esterly-Richardson Syndrome

Generalized Lentiginosis

Gorlin Syndrome Ii

Lentiginosis Profusa Syndrome

Lentigines, Electrocardiographic Conduction Abnormalities, Ocular Hypertelorism, Pulmonic Stenosis, Abnormal Genitalia, Retardation Of Growth, Deafnes

Diffuse Lentiginosis

Nsml

Familial Multiple Lentigines Syndrome

Alopecia-Epilepsy-Intellectual Disability Syndrome, Moynahan Type

Progressive Cardiomyopathic Lentiginosis Syndrome

Alopecia Epilepsy Oligophrenia Syndrome Of Moynahan

Cardiofaciocutaneous Syndrome 1

Cardiofaciocutaneous Syndrome

Cfc Syndrome

Cardio-Facio-Cutaneous Syndrome

CFC1

Cfcs

Cardio-Facial-Cutaneous Syndrome

Congenital Heart Defects Characteristic Facial Appearance Ectodermal Abnormalities And Growth Failure

Cardiofaciocutaneous Syndrome, Type 1

Rasopathy

Ras/Mitogen-Activated Protein Kinase Syndrome

Renal Hypodysplasia/Aplasia 1

Renal Agenesis

Renal Adysplasia

Renal Aplasia

RHDA1

Hereditary Renal Aplasia

Hra

Hereditary Urogenital Adysplasia

Hypodysplasia/Aplasia, Renal, Type 1

Congenital Absence Of Kidneys Syndrome

Congenital Absence Of Kidney

Aplastic Kidney

Rhabdomyosarcoma
Crouzon Syndrome

Crouzon Craniofacial Dysostosis

Craniofacial Dysostosis

Cfd1

Craniofacial Dysostosis Type 1

Crouzon Disease

Crouzon'S Disease

Craniofacial Dysostosis, Type I

Craniofacial Dysarthrosis

Craniofacial Dysostosis Syndrome

CS

Craniofacial Dysostosis Type I

Vogt Cephalosyndactyly

Vesicoureteral Reflux

Vesico-Ureteral Reflux

Cakut

Renal Or Urinary Tract Malformation

Congenital Anomalies Of Kidney And Urinary Tract

Congenital Anomaly Of Kidney And Urinary Tract

Congenital Anomalies Of The Kidney And Urinary Tract

Kidney And Urinary Tract, Anomalies, Congenital

Renal Hypodysplasia, Nonsyndromic, 1

Noonan Syndrome 1

Noonan Syndrome

NS1

Male Turner Syndrome

Female Pseudo-Turner Syndrome

Turner Phenotype With Normal Karyotype

Noonan Syndrome With Pigmented Villonodular Synovitis

Turner'S Phenotype, Karyotype Normal

Familial Turner Syndrome

Noonan'S Syndrome

Noonan-Ehmke Syndrome

Ns

Pseudo-Ullrich-Turner Syndrome

Turner Syndrome In Female With X Chromosome

Turner-Like Syndrome

Ullrich-Noonan Syndrome

Noonan-Like/Multiple Giant Cell Lesion Syndrome

Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

Pterygium Colli Syndrome

Noonan Syndrome, Type 1

Turner Syndrome, Male

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus SPRY1 MGD MGI:1345139
Macaca mulatta SPRY1 VGNC VGNC:77867
Rattus norvegicus SPRY1 RGD RGD:1309293
Bos taurus SPRY1 VGNC VGNC:35241
Felis catus SPRY1 VGNC VGNC:65649