SDS - serine dehydratase Gene

Homo sapiens

Also known as SDH

Gene ID: 10993 | Gene type: protein coding

About SDS

Cytogenetic location: 12q24.13 Genomic coordinates (GRCh38): 12:113,392,445-113,403,887 (from NCBI)

This gene has 6 transcripts (splice variants), 199 orthologues and 5 paralogues. Biased expression in liver (RPKM 130.0) and brain (RPKM 4.0).

Summary

This gene encodes one of three Enzymes that are involved in metabolizing serine and glycine. L-serine dehydratase converts L-serine to pyruvate and ammonia and requires pyridoxal phosphate as a cofactor. The encoded protein can also metabolize threonine to NH4+ and 2-ketobutyrate. The encoded protein is found predominantly in the liver. [provided by RefSeq, Jul 2008]

SDS Products(1)

mRNA	Protein	Name
NM_006843.3	NP_006834.2	L-serine dehydratase/L-threonine deaminase

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables L-serine ammonia-lyase activity	IDA IDA: Inferred from direct assay	15618015	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	15689518	GOA
enables pyridoxal phosphate binding	IDA IDA: Inferred from direct assay	15689518	GOA
enables pyridoxal phosphate binding	IMP IMP: Inferred from mutant phenotype	16580895	GOA
enables threonine deaminase activity	IDA IDA: Inferred from direct assay	15618015	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in L-serine catabolic process	IDA IDA: Inferred from direct assay	15689518	GOA
involved in pyruvate biosynthetic process	IDA IDA: Inferred from direct assay	15689518	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SDS Protein Structure

PALP

0
100
200
300
328 a.a.

Protein Preferred Names

Protein Names

L-serine dehydratase/L-threonine deaminase

L-serine ammonia-lyase

SDS Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SDS	P20132	TGM7	Homo sapiens	Q96PF1	Validated Y2H	32296183
Intra	SDS	P20132	DDI1	Homo sapiens	Q8WTU0	Validated Y2H	32296183
Intra	SDS	P20132	DDI1	Homo sapiens	Q8WTU0	Y2H Prey Pooling	32296183
Intra	SDS	P20132	DDI1	Homo sapiens	Q8WTU0	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Breast Abscess

Abscess Of Breast

Atrial Septal Defect 1

ASD1	Atrial Heart Septal Defect 1
Asd

Schizophrenia 1

SCZD1	Schizophrenia Susceptibility Locus, Chromosome 5-Related
Schizophrenia 1 With Or Without An Affective Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108717	Proteinase K		/	Unkown
HY-W099535	Lithium dodecyl sulfate		≥98.0%	Unkown
HY-D0014	Brilliant blue G-250		≥95.0%	Unkown
HY-136964	Sulfo-NHS-Biotin sodium		≥95.0%	Unkown
HY-D0232	Brilliant Blue R250		≥95.0%	Unkown
HY-Y0316B	Sodium dodecyl sulfate for electrophoresis		≥98.0%	Unkown
HY-D1590	BODIPY Green 8-P2M		99.21%	Unkown
HY-Y0700	Calconcarboxylic acid		/	Unkown
HY-119271	CMLD010509		99.11%	Unkown
HY-B1817A	Zinc acetate, 99.99% trace metals basis		99.99%	Unkown
HY-RS12599	SDS Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-119271A	(-)-CMLD010509		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SDS	VGNC	VGNC:80482
Rattus norvegicus	SDS	RGD	RGD:67376
Bos taurus	SDS	VGNC	VGNC:34399
Mus musculus	SDS	MGD	MGI:98270
Macaca mulatta	SDS	VGNC	VGNC:77148

Name
Email *

	Sorry, but the email address you supplied was invalid.