2. Gene
  3. OLIG1 - oligodendrocyte transcription factor 1 Gene

OLIG1 - oligodendrocyte transcription factor 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as BHLHB6; BHLHE21

Gene ID: 116448 | Gene type: protein coding

About OLIG1

Cytogenetic location: 21q22.11 Genomic coordinates (GRCh38): 21:33,070,141-33,072,413 (from NCBI)

This gene has 3 transcripts (splice variants), 157 orthologues and 15 paralogues.

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in neuron differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within neuron fate commitment. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

OLIG1 Products(1)

mRNA Protein Name
NM_138983.3 NP_620450.2 oligodendrocyte transcription factor 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
18923419 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OLIG1 Protein Structure

HLH

HLH: Helix-loop-helix DNA-binding domain (107 - 164)

  • 0
  • 100
  • 200
  • 271 a.a.
Protein Preferred Names Protein Names

oligodendrocyte transcription factor 1

basic domain, helix-loop-helix protein, class B, 6

OLIG1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
OLIG1 Q8TAK6 SH2D1B Homo sapiens O14796
Y2H Array
25814554
Intra
OLIG1 Q8TAK6 YES1 Homo sapiens P07947
Validated Y2H
25814554
Intra
OLIG1 Q8TAK6 YES1 Homo sapiens P07947
Y2H Array
25814554
Intra
OLIG1 Q8TAK6 GRB7 Homo sapiens Q14451
Validated Y2H
25814554
Intra
OLIG1 Q8TAK6 GRB7 Homo sapiens Q14451
Y2H Array
25814554
Intra
OLIG1 Q8TAK6 HCK Homo sapiens P08631-2
Y2H Array
25814554
Cross: Cross-species interaction Intra: Intraspecies interaction

OLIG1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82981 Olig1 Antibody (YA2726) WB, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Oligodendroglioma

Oligodendroglial Neoplasm

Oligodendroglial Tumor

Oligodendroglial Tumors

Well Differentiated Oligodendroglioma
Anaplastic Oligodendroglioma
Anaplastic Astrocytoma

Grade Iii Astrocytoma

Astrocytoma, Anaplastic

Grade Iii Astrocytic Tumor
Brain Cancer

Adult Brain Tumor

Malignant Neoplasm Of Brain

Brain Neoplasms

Brain Neoplasm

Neoplasm Of Brain

Primary Malignant Neoplasm Of Brain

Brain Tumors

Adult Malignant Brain Neoplasm

Brain Neoplasm, Adult

Bt - Brain Tumour

Malignant Brain Tumour

Malignant Primary Brain Neoplasm

Malignant Primary Brain Tumor

Malignant Tumor Of Adult Brain

Malignant Tumor Of Brain

Primary Brain Neoplasm

Primary Brain Tumor

Tumor Of The Brain

Brain Tumor, Adult

Brain Tumor Primary

Malignant Primary Brain Tumors

Primary Brain Tumors

Cancer, Brain

Brain Tumor, Primary
Periventricular Leukomalacia

Leukomalacia, Periventricular

Pvl

Leukomalacia Periventricular
Encephalomalacia
Pelizaeus-Merzbacher Disease

PMD

HLD1

Pelizaeus-Merzbacher Brain Sclerosis

Leukodystrophy, Hypomyelinating, 1

Diffuse Familial Brain Sclerosis

Pelizaeus Merzbacher Brain Sclerosis

Sudanophilic Leukodystrophy, Paelizeus-Merzbacher Type

Cockayne-Pelizaeus-Merzbacher Disease

Hypomyelinating Leukodystrophy 1

Leukodystrophy, Sudanophilic

Pelizaeus Merzbacher Disease

Hypomyelinating Leukodystrophy, 1

Sudanophilic Leukodystrophy

Pelizaeus-Merzbacher Disease, Connatal Form

Connatal Pmd

Pelizaeus-Merzbacher Disease Type Ii

Severe Pmd

Null Syndrome

Plp1 Null Syndrome

Pelizaeus-Merzbacher Disease, Null Syndrome

Brain Sclerosis Diffuse Familial

Sudanophilic Leukodystrophy Paelizeus-Merzbacher Type

Leukodystrophy Hypomyelinating 1

Diffuse Cerebral Sclerosis Of Schilder
Hypomyelinating Leukodystrophy

Hld

Leukodystrophy, Hypomyelinating
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09777 OLIG1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris OLIG1 VGNC VGNC:53034
Bos taurus OLIG1 VGNC VGNC:32425
Mus musculus OLIG1 MGD MGI:1355334
Rattus norvegicus OLIG1 RGD RGD:621129
Macaca mulatta OLIG1 VGNC VGNC:75413
Felis catus OLIG1 VGNC VGNC:102791