SH2D1B - SH2 domain containing 1B Gene

Homo sapiens

Also known as EAT2

Gene ID: 117157 | Gene type: protein coding

About SH2D1B

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:162,395,268-162,412,136 (from NCBI)

This gene has 2 transcripts (splice variants), 151 orthologues and 13 paralogues. Broad expression in spleen (RPKM 4.0), bone marrow (RPKM 1.8) and 14 other tissues.

Summary

By binding phosphotyrosines through its free Src (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001 [PubMed 11689425]).[supplied by OMIM, Mar 2008]

SH2D1B Products(1)

mRNA	Protein	Name
NM_053282.5	NP_444512.2	SH2 domain-containing protein 1B

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12928397	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SH2D1B Protein Structure

SH2

0
100
132 a.a.

Protein Preferred Names

Protein Names

SH2 domain-containing protein 1B

EAT-2

SH2D1B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SH2D1B	O14796	NFKBID	Homo sapiens	Q8NI38	Y2H Prey Pooling	32296183
Intra	SH2D1B	O14796	NFKBID	Homo sapiens	Q8NI38	Validated Y2H	32296183
Intra	SH2D1B	O14796	NFKBID	Homo sapiens	Q8NI38	Y2H Array	32296183
Intra	SH2D1B	O14796	MET	Homo sapiens	P08581	FPS	24728074
Intra	SH2D1B	O14796	TCF12	Homo sapiens	Q99081-3	Validated Y2H	32296183
Intra	SH2D1B	O14796	TCF12	Homo sapiens	Q99081-3	Y2H Prey Pooling	32296183
Intra	SH2D1B	O14796	TCF12	Homo sapiens	Q99081-3	Y2H Array	32296183
Intra	SH2D1B	O14796	TNK2	Homo sapiens	Q07912-2	Validated Y2H	32296183
Intra	SH2D1B	O14796	KIT	Homo sapiens	P10721	FPS	24728074
Intra	SH2D1B	O14796	SLAMF6	Homo sapiens	Q96DU3	Anti Bait CoIP	16920955
Intra	SH2D1B	O14796	CD244	Homo sapiens	Q9BZW8	Anti Bait CoIP	23346089
Intra	SH2D1B	O14796	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	SH2D1B	O14796	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	SH2D1B	O14796	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	SH2D1B	O14796	BLK	Homo sapiens	P51451	Validated Y2H	32296183
Intra	SH2D1B	O14796	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	32296183
Intra	SH2D1B	O14796	TRIM54	Homo sapiens	Q9BYV2	Validated Y2H	25416956
Intra	SH2D1B	O14796	TRIM54	Homo sapiens	Q9BYV2	Y2H Prey Pooling	32296183
Intra	SH2D1B	O14796	TRIM54	Homo sapiens	Q9BYV2	Validated Y2H	32296183
Intra	SH2D1B	O14796	OLIG1	Homo sapiens	Q8TAK6	Lumier	25814554
Intra	SH2D1B	O14796	GAB1	Homo sapiens	Q13480	FPS	24728074
Intra	SH2D1B	O14796	AR	Homo sapiens	P10275	FPS	24728074
Intra	SH2D1B	O14796	PLCG2	Homo sapiens	P16885	Pull Down	24642916
Intra	SH2D1B	O14796	SRC	Homo sapiens	P12931	Validated Y2H	32814053
Intra	SH2D1B	O14796	SRC	Homo sapiens	P12931	Y2H Array	32814053
Intra	SH2D1B	O14796	SRC	Homo sapiens	P12931	Y2H Pooling	32814053
Intra	SH2D1B	O14796	CD84	Homo sapiens	Q9UIB8	CoIP	12928397
Intra	SH2D1B	O14796	CD84	Homo sapiens	Q9UIB8	Pull Down	23322602
Intra	SH2D1B	O14796	AGR2	Homo sapiens	O95994	Validated Y2H	32296183
Intra	SH2D1B	O14796	AGR2	Homo sapiens	O95994	Y2H Array	32296183
Intra	SH2D1B	O14796	AGR2	Homo sapiens	O95994	Y2H Prey Pooling	32296183
Intra	SH2D1B	O14796	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	SH2D1B	O14796	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	SH2D1B	O14796	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	SH2D1B	O14796	MAGEB4	Homo sapiens	O15481	Y2H Prey Pooling	32296183
Intra	SH2D1B	O14796	MAGEB4	Homo sapiens	O15481	Validated Y2H	32296183
Intra	SH2D1B	O14796	MAGEB4	Homo sapiens	O15481	Y2H Array	32296183
Intra	SH2D1B	O14796	PLCG1	Homo sapiens	P19174	Pull Down	24642916
Intra	SH2D1B	O14796	PLCG1	Homo sapiens	P19174	SPR	24642916
Intra	SH2D1B	O14796	FOS	Homo sapiens	P01100	Y2H Pooling	32814053
Intra	SH2D1B	O14796	FOS	Homo sapiens	P01100	Validated Y2H	32814053
Intra	SH2D1B	O14796	FOS	Homo sapiens	P01100	Y2H Array	32814053
Intra	SH2D1B	O14796	q53hf2_human	Homo sapiens	Q53HF2	Y2H Array	25814554
Intra	SH2D1B	O14796	q53hf2_human	Homo sapiens	Q53HF2	Lumier	25814554

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Sarcoma

Connective And Soft Tissue Neoplasm	Tumor Of Soft Tissue And Skeleton
Sarcomas	Sarcoma - Category

Ewing Sarcoma

Neuroepithelioma	Ewing'S Tumor
Primitive Neuroectodermal Tumor	Ewings Sarcoma
Ewing'S Sarcoma	Peripheral Neuroepithelioma
ES	Ewings Sarcoma-Primitive Neuroectodermal Tumor
Localized Peripheral Primitive Neuroectodermal Tumor	Peripheral Primitive Neuroectodermal Tumor
Ewing Tumor	Sarcoma, Ewing'S
Ewing Family Of Tumors	Extraosseous Ewing Tumor
Askin Tumor	Ewing'S Family Localized Tumor
Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor	Localized Ewing Sarcoma
Localized Ewing'S Sarcoma	Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor
Localized Ewing'S Tumor	Pnet Of Thoracopulmonary Region
Tumor Of The Ewing Family	Skeletal Ewing Sarcoma
Osseous Ewing Sarcoma	Ppnet
Peripheral Pnet	Extraskeletal Ewing Sarcoma
Eoe	Extraosseous Ewing Sarcoma
Extraskeletal Ewing Tumor	Esft
Ewing Sarcoma Family Of Tumors	Pne
Pnet	Pnet Of The Chest Wall
Sarcoma, Ewing	Neuroectodermal Tumors, Primitive, Peripheral
Neuroectodermal Tumor, Primitive	Disorder Of Eye
Askin'S Tumor	Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor
Neuroepithelioma, Peripheral

Vertigo, Benign Recurrent

Benign Paroxysmal Positional Vertigo	Bppv
Vestibulopathy, Familial	BRV
Vertigo, Benign Paroxysmal Positional	Benign Paroxysmal Positional Nystagmus
Benign Recurrent Vertigo	Familial Benign Recurrent Vertigo
Familial Vestibulopathy	Benign Paroxysmal Nystagmus
Bppv - [Benign Positional Paroxysmal Vertigo]

Selective Immunoglobulin Deficiency Disease

Dysgammaglobulinemia

Cardiomyopathy, Familial Restrictive, 1

RCM1	Restrictive Cardiomyopathy 1
Rcm	Familial Restrictive Cardiomyopathy 1
Cardiomyopathy, Familial Restrictive 1	Cardiomyopathy, Restrictive, Familial, Type 1
Rcm-1

Episodic Ataxia, Type 2

Episodic Ataxia Type 2	EA2
Apca	Capa
Cerebellopathy, Hereditary Paroxysmal	Acetazolamide-Responsive Hereditary Paroxysmal Cerebellar Ataxia
Cerebellar Ataxia, Paroxysmal, Acetazolamide-Responsive	Episodic Ataxia With Nystagmus
Ataxia, Episodic, With Nystagmus	Episodic Ataxia, Nystagmus-Associated
Ataxia, Familial Paroxysmal	Acetazolamide-Responsive Episodic Ataxia Syndrome
Acetazolamide-Responsive, Hereditary, Paroxysmal, Cerebellar Ataxia	Ataxia, Familial, Paroxysmal
Nystagmus-Associated Episodic Ataxia	Familial Paroxysmal Ataxia
Episodic Ataxia 2	Ea-2
Episodic Ataxia Nystagmus-Associated	Hereditary Paroxysmal Cerebellopathy
Ataxia, Episodic, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12822	SH2D1B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SH2D1B	VGNC	VGNC:77349
Rattus norvegicus	SH2D1B	RGD	RGD:1563935
Canis familiaris	SH2D1B	VGNC	VGNC:53129
Bos taurus	SH2D1B	VGNC	VGNC:55680

Name
Email *

	Sorry, but the email address you supplied was invalid.