Mapk8 - mitogen-activated protein kinase 8 Gene

Rattus norvegicus

Also known as JNK

Gene ID: 116554 | Gene type: protein coding

About Mapk8

Primary_assembly 16: 8,638,924-8,721,981 reverse strand.mRatBN7.2:CM026989.1

This gene has 4 transcripts (splice variants), 291 orthologues, 21 paralogues and is associated with 47 phenotypes. Biased expression in Brain (RPKM 159.1), Muscle (RPKM 92.9) and 9 other tissues.

Summary

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced Apoptosis. This kinase is also involved in UV radiation induced Apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. [provided by RefSeq, Jul 2012]

Mapk8 Products(1)

mRNA	Protein	Name
NM_053829.2	NP_446281.2	mitogen-activated protein kinase 8

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables JUN kinase activity	IDA IDA: Inferred from direct assay	11849756	RGD
enables kinesin binding	IPI IPI: Inferred from physical interaction	18932217	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16618812	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in SMAD protein signal transduction	IMP IMP: Inferred from mutant phenotype	27769861	RGD
involved in cellular response to amyloid-beta	IEP IEP: Inferred from expression pattern	12534344	RGD
involved in cellular response to interleukin-1	IEP IEP: Inferred from expression pattern	9513050	RGD
involved in cellular response to oxygen-glucose deprivation	IEP IEP: Inferred from expression pattern	27769861	RGD
involved in cellular response to oxygen-glucose deprivation	IMP IMP: Inferred from mutant phenotype	27769861	RGD
involved in glial cell apoptotic process	IEP IEP: Inferred from expression pattern	14997384	RGD
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	15309413	RGD
involved in neuron development	IEP IEP: Inferred from expression pattern	17568197	RGD
involved in neuron projection development	IMP IMP: Inferred from mutant phenotype	16618812	RGD
acts upstream of or within neuronal stem cell population maintenance	IGI IGI: Inferred from genetic interaction	24388750	RGD
acts upstream of or within neuronal stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	24388750	RGD
involved in positive regulation of DNA replication	IMP IMP: Inferred from mutant phenotype	9487126	RGD
involved in positive regulation of apoptotic process	IEP IEP: Inferred from expression pattern	16699462	RGD
involved in positive regulation of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	11259632	RGD
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	12853963	RGD
involved in positive regulation of glial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	14997384	RGD
involved in positive regulation of microtubule polymerization	IMP IMP: Inferred from mutant phenotype	16618812	RGD
involved in positive regulation of neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	24388750	RGD
involved in positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	12534344	RGD
involved in positive regulation of neuron migration	IMP IMP: Inferred from mutant phenotype	24388750	RGD
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12011047	RGD
involved in regulation of centrosome cycle	IMP IMP: Inferred from mutant phenotype	24388750	RGD
involved in regulation of dense core granule transport	IDA IDA: Inferred from direct assay	29166604	RGD
involved in regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	24388750	RGD
involved in response to hydrogen peroxide	IDA IDA: Inferred from direct assay	14707549	RGD
involved in response to steroid hormone	IEP IEP: Inferred from expression pattern	14512437	RGD
involved in type B pancreatic cell apoptotic process	IMP IMP: Inferred from mutant phenotype	24475223	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	9714150	RGD
located in dendrite cytoplasm	IDA IDA: Inferred from direct assay	9714150	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	9714150	RGD
located in synapse	IDA IDA: Inferred from direct assay	29166604	RGD
located in vesicle	IDA IDA: Inferred from direct assay	16618812	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mapk8 Protein Structure

STKc_JNK

0
100
200
300
400
427 a.a.

Protein Preferred Names

Protein Names

mitogen-activated protein kinase 8

MAP kinase 8	MAPK 8
SAPK gamma	c-Jun N-terminal kinase 1
c-jun NH2-terminal kinase	p54 gamma
stress-activated protein kinase JNK1

Mapk8 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Mapk8	P49185	Syt4	Rattus norvegicus	P50232	Y2H	18046461
Intra	Mapk8	P49185	Syt4	Rattus norvegicus	P50232	Pull Down	18046461
Intra	Mapk8	P49185	Gria4	Rattus norvegicus	P19493	Anti Bait CoIP	18188153
Intra	Mapk8	P49185	Gria2	Rattus norvegicus	P19491-3	Anti Bait CoIP	18188153

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-128448	Carmoisine		≥98.0%	Unkown
HY-148063	DB0614		98.80%	Unkown
HY-148061	DB1113		99.28%	Unkown
HY-RS08123	Mapk8 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08121	MAPK8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08122	Mapk8 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08124	MAPK8IP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08125	MAPK8IP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08126	MAPK8IP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mapk8	NCBI	NCBI:5599

Name
Email *

	Sorry, but the email address you supplied was invalid.