CLC - Charcot-Leyden crystal galectin Gene

Homo sapiens

Also known as GAL10; Gal-10; LGALS10; LGALS10A; LPPL_HUMAN

Gene ID: 1178 | Gene type: protein coding

About CLC

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:39,731,255-39,738,029 (from NCBI)

This gene has 1 transcript (splice variant), 330 orthologues and 16 paralogues. Biased expression in bone marrow (RPKM 112.7), urinary bladder (RPKM 16.5) and 5 other tissues.

Summary

Lysophospholipases are Enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene is a lysophospholipase expressed in eosinophils and basophils. It hydrolyzes lysophosphatidylcholine to glycerophosphocholine and a free fatty acid. This protein may possess carbohydrate or IgE-binding activities. It is both structurally and functionally related to the Galectin family of beta-galactoside binding proteins. It may be associated with inflammation and some myeloid leukemias. [provided by RefSeq, Jul 2008]

CLC Products(1)

mRNA	Protein	Name
NM_001828.6	NP_001819.2	galectin-10

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	17502455	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
NOT contributes to lysophospholipase activity	IDA IDA: Inferred from direct assay	11834744	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11834744	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in T cell apoptotic process	IDA IDA: Inferred from direct assay	17502455	GOA
involved in regulation of T cell anergy	IMP IMP: Inferred from mutant phenotype	17502455	GOA
involved in regulation of T cell cytokine production	IMP IMP: Inferred from mutant phenotype	17502455	GOA
involved in regulation of activated T cell proliferation	IMP IMP: Inferred from mutant phenotype	17502455	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	17502455	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLC Protein Structure

Gal-bind_lectin

0
100
142 a.a.

Protein Preferred Names

Protein Names

galectin-10

Charcot-Leyden crystal protein

Recombinant CLC Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700073AF	Animal-Free Galectin-10 Protein, Human (His)	Q05315 (S2-R142)	≥95%

Related Diseases

Diseases

Alias

Allergic Rhinitis

Hay Fever	Allergic Rhinitis, Susceptibility To
ALRH	Atopic Rhinitis
Seasonal Allergic Rhinitis	Non-Seasonal Allergic Rhinitis
Perenial Allergic Rhinitis	Pollenosis
Rhinitis Allergic Seasonal	Rhinitis, Allergic, Perennial
Allergic Rhinitis, Cause Unspecified	Pollinosis
Pollen Allergy	Allergy Nos Due To Pollen
Summer Catarrh	Other Seasonal Allergic Rhinitis

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Galactosemia Iii

Galactose Epimerase Deficiency	Gale Deficiency
Udp-Galactose-4-Epimerase Deficiency	Epimerase Deficiency Galactosemia
Galactosemia Type 3	Gale-D
Uridine Diphosphate Galactose-4-Epimerase Deficiency	GALAC3
Galactosemia 3	Generalized Uridine Diphosphate Galactose-4-Epimerase Deficiency
Erythrocyte Uridine Diphosphate Galactose-4-Epimerase Deficiency	Galactosemia Type Iii
Udp-Galactose-4'-Epimerase Deficiency	Generalized Galactose Epimerase Deficiency
Generalized Gale Deficiency	Generalized Gale-D
Generalized Udp-Galactose-4-Epimerase Deficiency	Generalized Epimerase Deficiency Galactosemia
Erythrocyte Galactose Epimerase Deficiency	Erythrocyte Gale Deficiency
Erythrocyte Gale-D	Erythrocyte Udp-Galactose-4-Epimerase Deficiency
Erythrocyte Epimerase Deficiency Galactosemia	Galactosemias
Classical Galactosemia	Udpglucose 4-Epimerase Deficiency Disease

Esophagitis, Eosinophilic, 1

Eosinophilic Esophagitis	EOE1
Esophagitis, Eosinophilic	Ee

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112496	Cl-C6-PEG4-O-CH2COOH		≥98.0%	Unkown
HY-135306	Cl-C6-PEG4-C3-COOH		99.65%	Unkown
HY-158183	NMD670	Inhibitor	99.60%	Unkown
HY-P1105	GaTx2		98.40%	Unkown
HY-RS02747	CLC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W414069	Thiocholesterol		/	Unkown
HY-122732	OADS	Inhibitor	/	Unkown

Name
Email *

	Sorry, but the email address you supplied was invalid.