2. Gene
  3. PRAP1 - proline rich acidic protein 1 Gene

PRAP1 - proline rich acidic protein 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as UPA; PRO1195

Gene ID: 118471 | Gene type: protein coding

About PRAP1

Cytogenetic location: 10q26.3 Genomic coordinates (GRCh38): 10:133,347,373-133,352,683 (from NCBI)

This gene has 2 transcripts (splice variants) and 70 orthologues. Biased expression in small intestine (RPKM 388.5), duodenum (RPKM 348.9) and 3 other tissues.

Summary

Predicted to enable triglyceride binding activity. Involved in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; deactivation of mitotic spindle assembly checkpoint; and negative regulation of apoptotic process. Predicted to be located in endoplasmic reticulum and extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

PRAP1 Products(2)

mRNA Protein Name
NM_001145201.2 NP_001138673.1 proline-rich acidic protein 1 isoform 2 precursor
NM_145202.5 NP_660203.3 proline-rich acidic protein 1 isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
24374861 GOA
Biological Process GO Annotation Evidence Reference Source
involved in DNA damage response IDA
IDA: Inferred from direct assay
23235459 GOA
involved in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IMP
IMP: Inferred from mutant phenotype
23235459 GOA
involved in deactivation of mitotic spindle assembly checkpoint IDA
IDA: Inferred from direct assay
24374861 GOA
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
23235459 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRAP1 Protein Structure

PRAP

PRAP: Proline-rich acidic protein 1, pregnancy-specific uterine (105 - 149)

  • 0
  • 100
  • 151 a.a.
Protein Preferred Names Protein Names

proline-rich acidic protein 1

epididymis secretory sperm binding protein

PRAP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra PRAP1 Q96NZ9 UBQLN1 Homo sapiens Q9UMX0-2
Y2H Prey Pooling
25416956
Intra PRAP1 Q96NZ9 UBQLN1 Homo sapiens Q9UMX0-2
Y2H Array
25416956
Intra PRAP1 Q96NZ9 UBQLN1 Homo sapiens Q9UMX0-2
Validated Y2H
25416956
Intra PRAP1 Q96NZ9 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra PRAP1 Q96NZ9 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra PRAP1 Q96NZ9 SGTA Homo sapiens O43765
Y2H Prey Pooling
32296183
Intra PRAP1 Q96NZ9 SGTA Homo sapiens O43765
Y2H Prey Pooling
25416956
Intra PRAP1 Q96NZ9 SGTA Homo sapiens O43765
Y2H Array
32296183
Intra PRAP1 Q96NZ9 HSPA6 Homo sapiens P17066
Y2H Prey Pooling
32296183
Intra PRAP1 Q96NZ9 HSPA6 Homo sapiens P17066
Y2H Array
32296183
Intra PRAP1 Q96NZ9 UBQLN1 Homo sapiens Q9UMX0
Y2H Prey Pooling
32296183
Intra PRAP1 Q96NZ9 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32296183
Intra PRAP1 Q96NZ9 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
25416956
Intra PRAP1 Q96NZ9 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
32296183
Intra PRAP1 Q96NZ9 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Intra PRAP1 Q96NZ9 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Intra PRAP1 Q96NZ9 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Intra PRAP1 Q96NZ9 MRFAP1 Homo sapiens Q9Y605
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PRAP1 Proteins

Cat. No. Product Name Accession Purity
HY-P71004 PRAP1 Protein, Human (HEK293, His) Q96NZ9/AAL16670.1 (V21-Q151) ≥95%

Related Diseases

Diseases Alias
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11050 PRAP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PRAP1 RGD RGD:61876
Canis familiaris PRAP1 VGNC VGNC:53010
Mus musculus PRAP1 MGD MGI:893573
Bos taurus PRAP1 VGNC VGNC:55965