HSPA6 - heat shock protein family A (Hsp70) member 6 Gene

Homo sapiens

Also known as HSP70B'

Gene ID: 3310 | Gene type: protein coding

About HSPA6

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:161,524,540-161,526,894 (from NCBI)

This gene has 1 transcript (splice variant), 52 orthologues and 13 paralogues.

Summary

Enables Enzyme binding activity; heat shock protein binding activity; and unfolded protein binding activity. Involved in cellular response to heat and protein refolding. Located in centriole and cytosol. Colocalizes with COP9 signalosome. [provided by Alliance of Genome Resources, Apr 2022]

HSPA6 Products(1)

mRNA	Protein	Name
NM_002155.5	NP_002146.2	heat shock 70 kDa protein 6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP hydrolysis activity	IDA IDA: Inferred from direct assay	21231916	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	23921388	GOA
enables heat shock protein binding	IPI IPI: Inferred from physical interaction	21231916	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21044950	GOA
enables unfolded protein binding	IDA IDA: Inferred from direct assay	21231916	GOA

Biological Process GO Annotation	Evidence	Reference	Source
NOT involved in cellular heat acclimation	IMP IMP: Inferred from mutant phenotype	21231916	GOA
involved in cellular response to heat	IDA IDA: Inferred from direct assay	24061851	GOA
involved in cellular response to heat	IMP IMP: Inferred from mutant phenotype	21597468	GOA
involved in protein refolding	IDA IDA: Inferred from direct assay	21231916	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of COP9 signalosome	IDA IDA: Inferred from direct assay	18850735	GOA
located in centriole	IDA IDA: Inferred from direct assay	24061851	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	24061851	GOA
located in cytosol	IDA IDA: Inferred from direct assay	21231916	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HSPA6 Protein Structure

HSP70

0
100
200
300
400
500
600
643 a.a.

Protein Preferred Names

Protein Names

heat shock 70 kDa protein 6

epididymis secretory sperm binding protein

HSPA6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HSPA6	P17066	C22orf15	Homo sapiens	Q8WYQ4-2	Validated Y2H	32296183
Intra	HSPA6	P17066	COMMD6	Homo sapiens	Q7Z4G1	Validated Y2H	32296183
Intra	HSPA6	P17066	PRAP1	Homo sapiens	Q96NZ9	Validated Y2H	32296183
Intra	HSPA6	P17066	BAG4	Homo sapiens	O95429	Y2H Prey Pooling	32296183
Intra	HSPA6	P17066	BAG4	Homo sapiens	O95429	Y2H Array	32296183
Intra	HSPA6	P17066	LGALS7	Homo sapiens	P47929	Validated Y2H	32296183
Intra	HSPA6	P17066	PPIB	Homo sapiens	P23284	Validated Y2H	32296183
Intra	HSPA6	P17066	RPA1	Homo sapiens	P27694	Validated Y2H	32296183
Intra	HSPA6	P17066	TERF1	Homo sapiens	P54274	BiFC	21044950
Intra	HSPA6	P17066	TERF1	Homo sapiens	P54274	Pull Down	21044950
Intra	HSPA6	P17066	KRT222	Homo sapiens	Q8N1A0	Validated Y2H	32296183
Intra	HSPA6	P17066	FLNA	Homo sapiens	P21333-2	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06435	HSPA6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	HSPA6	RGD	RGD:1586661
Bos taurus	HSPA6	VGNC	VGNC:55236

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