2. Gene
  3. TARS3 - threonyl-tRNA synthetase 3 Gene

TARS3 - threonyl-tRNA synthetase 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TARSL2; ThrRS-L

Gene ID: 123283 | Gene type: protein coding

About TARS3

This gene has 7 transcripts (splice variants), 199 orthologues and 4 paralogues. Ubiquitous expression in brain (RPKM 4.4), heart (RPKM 3.4) and 25 other tissues.

Summary

Predicted to enable threonine-tRNA Ligase activity. Predicted to be involved in threonyl-tRNA aminoacylation. Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

TARS3 Products(1)

mRNA Protein Name
NM_152334.3 NP_689547.2 threonine--tRNA ligase 2, cytoplasmic
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
24312579 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TARS3 Protein Structure

TGS

TGS: TGS domain (167 - 222)

tRNA_SAD

tRNA_SAD: Threonyl and Alanyl tRNA synthetase second additional domain (329 - 377)

tRNA-synt_2b

tRNA-synt_2b: tRNA synthetase class II core domain (G, H, P, S and T) (432 - 594)

HGTP_anticodon

HGTP_anticodon: Anticodon binding domain (699 - 789)

  • 0
  • 200
  • 400
  • 600
  • 802 a.a.
Protein Preferred Names Protein Names

threonine--tRNA ligase 2, cytoplasmic

probable threonine--tRNA ligase 2, cytoplasmic

TARS3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
TARS3 A2RTX5 b2rdx5_human Homo sapiens B2RDX5
Validated Y2H
25416956
Intra
TARS3 A2RTX5 LGALS14 Homo sapiens Q8TCE9
Validated Y2H
32296183
Intra
TARS3 A2RTX5 TARS1 Homo sapiens P26639
Validated Y2H
25416956
Intra
TARS3 A2RTX5 TARS1 Homo sapiens P26639
Validated Y2H
32296183
Intra
TARS3 A2RTX5 TARS2 Homo sapiens Q9BW92
Validated Y2H
32296183
Intra
TARS3 A2RTX5 TP53BP2 Homo sapiens Q05BL1
Validated Y2H
32296183
Intra
TARS3 A2RTX5 TP53BP2 Homo sapiens Q05BL1
Y2H Array
32296183
Intra
TARS3 A2RTX5 TP53BP2 Homo sapiens Q05BL1
Y2H Prey Pooling
32296183
Intra
TARS3 A2RTX5 ARPC3 Homo sapiens O15145
Validated Y2H
32296183
Intra
TARS3 A2RTX5 ATF4 Homo sapiens P18848
Y2H Array
32296183
Intra
TARS3 A2RTX5 ATF4 Homo sapiens P18848
Y2H Prey Pooling
32296183
Intra
TARS3 A2RTX5 ATF4 Homo sapiens P18848
Validated Y2H
32296183
Intra
TARS3 A2RTX5 ECSIT Homo sapiens Q9BQ95
Validated Y2H
32296183
Intra
TARS3 A2RTX5 ECSIT Homo sapiens Q9BQ95
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Antisynthetase Syndrome

As Syndrome

Anti-Jo1 Syndrome
Granulomatous Myositis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14211 TARS3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TARS3 VGNC VGNC:35606
Rattus norvegicus TARS3 RGD RGD:1311308
Canis familiaris TARS3 VGNC VGNC:47111
Mus musculus TARS3 MGD MGI:2444486
Macaca mulatta TARS3 VGNC VGNC:78205
Felis catus TARS3 VGNC VGNC:65957