ARPC3 - actin related protein 2/3 complex subunit 3 Gene

Homo sapiens

Also known as ARC21; p21-Arc

Gene ID: 10094 | Gene type: protein coding

About ARPC3

Cytogenetic location: 12q24.11 Genomic coordinates (GRCh38): 12:110,434,823-110,450,337 (from NCBI)

This gene has 9 transcripts (splice variants) and 222 orthologues. Ubiquitous expression in lymph node (RPKM 232.8), bone marrow (RPKM 231.9) and 25 other tissues.

Summary

This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been conserved through evolution and is implicated in the control of actin polymerization in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]

ARPC3 Products(2)

mRNA	Protein	Name
NM_001287222.2	NP_001274151.1	actin-related protein 2/3 complex subunit 3 isoform 2
NM_001278556.2	NP_001265485.1	actin-related protein 2/3 complex subunit 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to actin filament binding	IDA IDA: Inferred from direct assay	11741539	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11162547	GOA
enables structural constituent of cytoskeleton	IDA IDA: Inferred from direct assay	11741539	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Arp2/3 complex-mediated actin nucleation	IDA IDA: Inferred from direct assay	11741539	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Arp2/3 protein complex	IDA IDA: Inferred from direct assay	11741539	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	9230079	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARPC3 Protein Structure

P21-Arc

0
100
178 a.a.

Protein Preferred Names

Protein Names

actin-related protein 2/3 complex subunit 3

ARP2/3 protein complex subunit p21	actin related protein 2/3 complex, subunit 3, 21kDa
arp2/3 complex 21 kDa subunit

ARPC3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ARPC3	O15145	RETREG3	Homo sapiens	Q86VR2	Y2H Prey Pooling	32296183
Intra	ARPC3	O15145	RETREG3	Homo sapiens	Q86VR2	Validated Y2H	32296183
Intra	ARPC3	O15145	RETREG3	Homo sapiens	Q86VR2	Y2H Array	32296183
Intra	ARPC3	O15145	DUSP29	Homo sapiens	Q68J44	Validated Y2H	32296183
Intra	ARPC3	O15145	DUSP29	Homo sapiens	Q68J44	Y2H Array	32296183
Intra	ARPC3	O15145	DUSP29	Homo sapiens	Q68J44	Y2H Prey Pooling	32296183
Intra	ARPC3	O15145	TARS3	Homo sapiens	A2RTX5	Y2H Array	32296183
Intra	ARPC3	O15145	TARS3	Homo sapiens	A2RTX5	Y2H Prey Pooling	32296183
Intra	ARPC3	O15145	RBBP8NL	Homo sapiens	Q8NC74	Y2H Array	32296183
Intra	ARPC3	O15145	RBBP8NL	Homo sapiens	Q8NC74	Validated Y2H	32296183
Intra	ARPC3	O15145	RBBP8NL	Homo sapiens	Q8NC74	Y2H Prey Pooling	32296183
Intra	ARPC3	O15145	POU2F1	Homo sapiens	P14859-6	Y2H Prey Pooling	32296183
Intra	ARPC3	O15145	POU2F1	Homo sapiens	P14859-6	Validated Y2H	32296183
Intra	ARPC3	O15145	POU2F1	Homo sapiens	P14859-6	Y2H Array	32296183
Intra	ARPC3	O15145	SYBU	Homo sapiens	Q9NX95-5	Validated Y2H	32296183
Intra	ARPC3	O15145	SYBU	Homo sapiens	Q9NX95-5	Y2H Prey Pooling	32296183
Intra	ARPC3	O15145	SYBU	Homo sapiens	Q9NX95-5	Y2H Array	32296183
Intra	ARPC3	O15145	LATS1	Homo sapiens	O95835-2	Y2H Array	32296183
Intra	ARPC3	O15145	LATS1	Homo sapiens	O95835-2	Y2H Prey Pooling	32296183
Intra	ARPC3	O15145	LATS1	Homo sapiens	O95835-2	Validated Y2H	32296183
Cross	ARPC3	O15145	N	SARS-CoV-2	P0DTC9	Y2H Array	36217030
Intra	ARPC3	O15145	CCR10	Homo sapiens	P46092	Y2H Prey Pooling	32296183
Intra	ARPC3	O15145	CCR10	Homo sapiens	P46092	Validated Y2H	32296183
Intra	ARPC3	O15145	CCR10	Homo sapiens	P46092	Y2H Array	32296183
Intra	ARPC3	O15145	ARPC4	Homo sapiens	P59998	Anti Tag CoIP	33961781
Intra	ARPC3	O15145	ARPC4	Homo sapiens	P59998	Anti Tag CoIP	35271311
Intra	ARPC3	O15145	ARPC4	Homo sapiens	P59998	Y2H Prey Pooling	32296183
Intra	ARPC3	O15145	ARPC4	Homo sapiens	P59998	Validated Y2H	32296183
Intra	ARPC3	O15145	ARPC4	Homo sapiens	P59998	Y2H Array	32296183
Intra	ARPC3	O15145	ZNF576	Homo sapiens	Q9H609	Y2H Prey Pooling	32296183
Intra	ARPC3	O15145	ZNF576	Homo sapiens	Q9H609	Validated Y2H	32296183
Intra	ARPC3	O15145	ZNF576	Homo sapiens	Q9H609	Y2H Array	32296183
Intra	ARPC3	O15145	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956
Intra	ARPC3	O15145	GOLGA2	Homo sapiens	Q08379	Validated Y2H	32296183
Intra	ARPC3	O15145	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	ARPC3	O15145	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	ARPC3	O15145	GOLGA2	Homo sapiens	Q08379	Validated Y2H	25416956
Intra	ARPC3	O15145	NRIP1	Homo sapiens	P48552	Validated Y2H	25416956
Intra	ARPC3	O15145	FAM9A	Homo sapiens	Q8IZU1	Y2H Prey Pooling	32296183
Intra	ARPC3	O15145	FAM9A	Homo sapiens	Q8IZU1	Validated Y2H	32296183
Intra	ARPC3	O15145	FAM9A	Homo sapiens	Q8IZU1	Y2H Array	32296183
Intra	ARPC3	O15145	HOXA3	Homo sapiens	O43365	Y2H Prey Pooling	25416956
Intra	ARPC3	O15145	HOXA3	Homo sapiens	O43365	Y2H Prey Pooling	32296183
Intra	ARPC3	O15145	HOXA3	Homo sapiens	O43365	Validated Y2H	32296183
Intra	ARPC3	O15145	HOXA3	Homo sapiens	O43365	Y2H Array	32296183
Intra	ARPC3	O15145	WASL	Homo sapiens	O00401	Validated Y2H	25416956
Intra	ARPC3	O15145	WASL	Homo sapiens	O00401	Y2H Array	32296183
Intra	ARPC3	O15145	WASL	Homo sapiens	O00401	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Porokeratosis

Disseminated Superficial Actinic Porokeratosis	Dsap
Porokeratosis Of Mibelli	Porokeratosis, Disseminated Superficial Actinic
Porokeratosis, Disseminated Superficial Actinic, 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01018	ARPC3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01019	Arpc3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01020	Arpc3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ARPC3	VGNC	VGNC:99890
Rattus norvegicus	ARPC3	RGD	RGD:1311985
Bos taurus	ARPC3	VGNC	VGNC:53890
Mus musculus	ARPC3	MGD	MGI:1928375

Name
Email *

	Sorry, but the email address you supplied was invalid.