ATF4 - activating transcription factor 4 Gene

Homo sapiens

Also known as CREB2; TXREB; CREB-2; TAXREB67

Gene ID: 468 | Gene type: protein coding

About ATF4

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:39,520,559-39,522,686 (from NCBI)

This gene has 11 transcripts (splice variants), 269 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 183.9), fat (RPKM 87.6) and 25 other tissues.

Summary

This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic Amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011]

ATF4 Products(2)

mRNA	Protein	Name
NM_001675.4	NP_001666.2	cyclic AMP-dependent transcription factor ATF-4
NM_182810.3	NP_877962.1	cyclic AMP-dependent transcription factor ATF-4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	15788408	GOA
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	11960987	GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	11478948	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	11478948	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16343488	GOA
enables leucine zipper domain binding	IDA IDA: Inferred from direct assay	11478948	GOA
enables promoter-specific chromatin binding	IDA IDA: Inferred from direct assay	17267404	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9488481	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	20873783	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	22915762	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA
contributes to transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	12871976	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	21113145	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in HRI-mediated signaling	IDA IDA: Inferred from direct assay	32132706	GOA
involved in L-asparagine metabolic process	IDA IDA: Inferred from direct assay	11960987	GOA
involved in cellular response to glucose starvation	IMP IMP: Inferred from mutant phenotype	22915762	GOA
involved in cellular response to leucine starvation	IDA IDA: Inferred from direct assay	17267404	GOA
involved in cellular response to oxidative stress	IMP IMP: Inferred from mutant phenotype	21113145	GOA
involved in integrated stress response signaling	IDA IDA: Inferred from direct assay	32132707	GOA
involved in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	23392669	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15775988	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	11960987	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	16445384	GOA
involved in positive regulation of transcription by RNA polymerase I	IMP IMP: Inferred from mutant phenotype	22915762	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11478948	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	15788408	GOA
involved in positive regulation of vascular endothelial growth factor production	IMP IMP: Inferred from mutant phenotype	22915762	GOA
involved in regulation of osteoblast differentiation	IDA IDA: Inferred from direct assay	15109498	GOA
involved in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	12871976	GOA
involved in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	21113145	GOA
involved in response to nutrient levels	IDA IDA: Inferred from direct assay	11960987	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of ATF1-ATF4 transcription factor complex	IDA IDA: Inferred from direct assay	12871976	GOA
part of ATF4-CREB1 transcription factor complex	IDA IDA: Inferred from direct assay	12871976	GOA
part of CHOP-ATF4 complex	IDA IDA: Inferred from direct assay	11478948	GOA
part of CHOP-ATF4 complex	IPI IPI: Inferred from physical interaction	18940792	GOA
located in Lewy body core	IDA IDA: Inferred from direct assay	23392669	GOA
part of RNA polymerase II transcription regulator complex	IPI IPI: Inferred from physical interaction	20102225	GOA
colocalizes with centrosome	IDA IDA: Inferred from direct assay	20873783	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	23392669	GOA
located in neuron projection	IDA IDA: Inferred from direct assay	23392669	GOA
located in nuclear periphery	IDA IDA: Inferred from direct assay	23392669	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11478948	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	20873783	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATF4 Protein Structure

bZIP_1

0
100
200
300
351 a.a.

Protein Preferred Names

Protein Names

cyclic AMP-dependent transcription factor ATF-4

DNA-binding protein TAXREB67

ATF4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ATF4	P18848	GOLGA8F	Homo sapiens	Q08AF8	Y2H Prey Pooling	25416956
Intra	ATF4	P18848	BFSP2	Homo sapiens	Q13515	Validated Y2H	32296183
Intra	ATF4	P18848	BFSP2	Homo sapiens	Q13515	Y2H Array	25416956
Intra	ATF4	P18848	BATF3	Homo sapiens	Q9NR55	FRET	23661758
Intra	ATF4	P18848	EXOC1	Homo sapiens	Q9NV70	Validated Y2H	32296183
Intra	ATF4	P18848	CEP83	Homo sapiens	Q9Y592-2	Validated Y2H	32296183
Intra	ATF4	P18848	ATF2	Homo sapiens	P15336	FRET	23661758
Intra	ATF4	P18848	CEBPA	Homo sapiens	P49715	Peptide Array	20102225
Intra	ATF4	P18848	TBC1D25	Homo sapiens	Q3MII6	Anti Tag CoIP	33961781
Intra	ATF4	P18848	TBC1D25	Homo sapiens	Q3MII6	Anti Tag CoIP	28514442
Intra	ATF4	P18848	JDP2	Homo sapiens	Q8WYK2	Validated Y2H	32296183
Intra	ATF4	P18848	NFE2L2	Homo sapiens	Q16236	CH-IP	26700459
Intra	ATF4	P18848	NFE2L2	Homo sapiens	Q16236	FRET	23661758
Intra	ATF4	P18848	SAPCD2	Homo sapiens	Q86UD0	Validated Y2H	32296183
Intra	ATF4	P18848	MAF	Homo sapiens	O75444	FRET	23661758
Intra	ATF4	P18848	BTRC	Homo sapiens	Q9Y297	Y2H Prey Pooling	25416956
Intra	ATF4	P18848	BTRC	Homo sapiens	Q9Y297	Validated Y2H	32296183
Intra	ATF4	P18848	BTRC	Homo sapiens	Q9Y297	Y2H Array	25416956
Intra	ATF4	P18848	BTRC	Homo sapiens	Q9Y297	Anti Bait CoIP	11238952
Intra	ATF4	P18848	POLR2C	Homo sapiens	P19387	Anti Tag CoIP	12860379
Intra	ATF4	P18848	POLR2C	Homo sapiens	P19387	Pull Down	12860379
Intra	ATF4	P18848	HAUS7	Homo sapiens	Q99871	Y2H Pooling	16189514
Intra	ATF4	P18848	HAUS7	Homo sapiens	Q99871	Y2H Pooling	19447967
Intra	ATF4	P18848	TRIB3	Homo sapiens	Q96RU7	Y2H Prey Pooling	25416956
Intra	ATF4	P18848	TRIB3	Homo sapiens	Q96RU7	Validated Y2H	32296183
Intra	ATF4	P18848	TRIB3	Homo sapiens	Q96RU7	Anti Tag CoIP	25416956
Intra	ATF4	P18848	TRIB3	Homo sapiens	Q96RU7	Anti Tag CoIP	12743605
Intra	ATF4	P18848	TRIB3	Homo sapiens	Q96RU7	Y2H Array	25416956
Intra	ATF4	P18848	TRIB3	Homo sapiens	Q96RU7	Y2H Array	20211142
Intra	ATF4	P18848	AP1M1	Homo sapiens	Q9BXS5	Validated Y2H	32296183
Intra	ATF4	P18848	GOLGA1	Homo sapiens	Q92805	Validated Y2H	32296183
Intra	ATF4	P18848	GOLGA1	Homo sapiens	Q92805	Validated Y2H	25416956
Intra	ATF4	P18848	GOLGA1	Homo sapiens	Q92805	Y2H Prey Pooling	25416956
Intra	ATF4	P18848	GOLGA1	Homo sapiens	Q92805	Y2H Array	25416956
Intra	ATF4	P18848	CREBZF	Homo sapiens	Q9NS37	Pull Down	16343488
Intra	ATF4	P18848	CCDC106	Homo sapiens	Q9BWC9	Validated Y2H	32296183
Intra	ATF4	P18848	CCDC106	Homo sapiens	Q9BWC9	Y2H Prey Pooling	25416956
Intra	ATF4	P18848	CCDC106	Homo sapiens	Q9BWC9	Y2H Array	31515488
Intra	ATF4	P18848	CCDC106	Homo sapiens	Q9BWC9	Validated Y2H	25416956
Intra	ATF4	P18848	TTR	Homo sapiens	P02766	Y2H Pooling	16189514
Intra	ATF4	P18848	ATF3	Homo sapiens	P18847	FRET	23661758
Intra	ATF4	P18848	ATF3	Homo sapiens	P18847	Anti Bait CoIP	19164757
Intra	ATF4	P18848	ATF3	Homo sapiens	P18847	Anti Tag CoIP	19164757
Intra	ATF4	P18848	ATF3	Homo sapiens	P18847	EMSA	19164757
Intra	ATF4	P18848	ATF3	Homo sapiens	P18847	Peptide Array	20102225
Intra	ATF4	P18848	GPS2	Homo sapiens	Q13227	Y2H Array	25416956
Intra	ATF4	P18848	GPS2	Homo sapiens	Q13227	Y2H Pooling	16189514
Intra	ATF4	P18848	GPS2	Homo sapiens	Q13227	Y2H Prey Pooling	25416956
Intra	ATF4	P18848	GPS2	Homo sapiens	Q13227	Validated Y2H	25416956
Intra	ATF4	P18848	GPS2	Homo sapiens	Q13227	Validated Y2H	32296183
Intra	ATF4	P18848	NAP1L5	Homo sapiens	Q96NT1	Validated Y2H	32296183
Intra	ATF4	P18848	NDC80	Homo sapiens	O14777	Y2H Array	29892012
Intra	ATF4	P18848	NDC80	Homo sapiens	O14777	Y2H Array	31515488
Intra	ATF4	P18848	NDC80	Homo sapiens	O14777	Validated Y2H	25416956
Intra	ATF4	P18848	NDC80	Homo sapiens	O14777	Y2H Array	25416956
Intra	ATF4	P18848	NDC80	Homo sapiens	O14777	Y2H Prey Pooling	25416956
Intra	ATF4	P18848	CEBPG	Homo sapiens	P53567	FRET	23661758
Intra	ATF4	P18848	CEBPG	Homo sapiens	P53567	Y2H Array	20211142
Intra	ATF4	P18848	CEBPG	Homo sapiens	P53567	Y2H Prey Pooling	25416956
Intra	ATF4	P18848	CEBPG	Homo sapiens	P53567	Peptide Array	20102225
Intra	ATF4	P18848	CEBPG	Homo sapiens	P53567	Validated Y2H	25416956
Intra	ATF4	P18848	CEBPG	Homo sapiens	P53567	Validated Y2H	32296183
Intra	ATF4	P18848	CEBPG	Homo sapiens	P53567	Y2H Array	25416956
Intra	ATF4	P18848	LDOC1	Homo sapiens	O95751	Validated Y2H	25416956
Intra	ATF4	P18848	LDOC1	Homo sapiens	O95751	Y2H Array	25416956
Intra	ATF4	P18848	LDOC1	Homo sapiens	O95751	Y2H Pooling	16189514
Intra	ATF4	P18848	LDOC1	Homo sapiens	O95751	Y2H Array	31515488
Intra	ATF4	P18848	LDOC1	Homo sapiens	O95751	Y2H Prey Pooling	25416956
Intra	ATF4	P18848	DDIT3	Homo sapiens	P35638	Peptide Array	20102225
Intra	ATF4	P18848	DDIT3	Homo sapiens	P35638	FRET	23661758
Intra	ATF4	P18848	FOSL1	Homo sapiens	P15407	FRET	23661758
Intra	ATF4	P18848	GCC1	Homo sapiens	Q96CN9	Validated Y2H	25416956
Intra	ATF4	P18848	GCC1	Homo sapiens	Q96CN9	Validated Y2H	32296183
Intra	ATF4	P18848	GCC1	Homo sapiens	Q96CN9	Y2H Prey Pooling	25416956
Intra	ATF4	P18848	JUNB	Homo sapiens	P17275	Y2H	21988832
Intra	ATF4	P18848	JUNB	Homo sapiens	P17275	Confocal	21988832
Intra	ATF4	P18848	BATF	Homo sapiens	Q16520	FRET	23661758
Intra	ATF4	P18848	CEBPD	Homo sapiens	P49716	Peptide Array	20102225
Intra	ATF4	P18848	JUN	Homo sapiens	P05412	FRET	23661758
Intra	ATF4	P18848	FOS	Homo sapiens	P01100	Peptide Array	20102225
Intra	ATF4	P18848	FOS	Homo sapiens	P01100	PLA	25241761
Intra	ATF4	P18848	BTRC	Homo sapiens	Q9Y297-2	Y2H	11238952
Intra	ATF4	P18848	BTRC	Homo sapiens	Q9Y297-2	Confocal	11238952
Intra	ATF4	P18848	BTRC	Homo sapiens	Q9Y297-2	Anti Tag CoIP	11238952
Intra	ATF4	P18848	DAPK2	Homo sapiens	Q9UIK4-2	Anti Tag CoIP	21408167
Intra	ATF4	P18848	CEBPB	Homo sapiens	P17676	Peptide Array	20102225

Cross: Cross-species interaction Intra: Intraspecies interaction

ATF4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80553	ATF4 Antibody	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
HY-P83667	Phospho-ATF4 (Ser219) Antibody	WB	Human

Related Diseases

Diseases

Alias

Coffin-Lowry Syndrome

CLS	Coffin Syndrome 1
Coffin Syndrome	Intellectual Disability With Osteocartilaginous Abnormalities
Dwarfism, Lean Spastic Type	Lean Spastic Dwarfism
Mental Retardation With Osteocartilaginous Abnormalities	Coffin Lowry Syndrome

Fatty Liver Disease

Alcoholic Fatty Liver	Fatty Liver
Fatty Liver, Alcoholic	Fatty Change Of Liver
Hepatic Lipidosis	Steatosis Of Liver
Fatty Liver Alcoholic	Steatohepatitis
Etoh Fatty Liver	Etoh Fatty Liver Metamorphosis
Fatty Etoh Liver Necrosis

Liver Disease

Liver Failure	Liver Diseases
Abnormality Of The Liver	Liver Dysfunction
Disorder Of Liver	Hepatic Disorder
Hepatic Disease	Disease Of Bilirubin Metabolism
Disorder Of Bilirubin Metabolism	Liver Decompensation
Liver Function Failure	Hepatic Failure Nos
Liver Failure Nos	End Stage Liver Disease
Decompensated Liver Failure	Decompensation Of Liver Function
Hepatic Decompensation	Hepatic Insufficiency
Liver Cell Necrosis With Hepatic Failure	Liver Insufficiency
Decompensated Liver Disease	End Stage Liver Failure
Liver Necrosis With Hepatic Failure

Epiphyseal Dysplasia, Multiple, With Early-Onset Diabetes Mellitus

Wolcott-Rallison Syndrome	Med-Iddm Syndrome
Iddm-Med Syndrome	Wolcott Rallison Syndrome
WRS	Epiphyseal Dysplasia Multiple With Early-Onset Diabetes Mellitus
Early-Onset Diabetes Mellitus With Multiple Epiphyseal Dysplasia	Multiple Epiphyseal Dysplasia With Early-Onset Diabetes Mellitus

Leukodystrophy

Leukodystrophies

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia	Acute T Cell Leukemia
Precursor T Lymphoblastic Leukemia	Precursor T-Lymphoblastic Lymphoma/Leukemia
T Acute Lymphoblastic Leukemia	T-Cell Acute Lymphocytic Leukaemia
T-Cell Lymphoblastic Leukemia/Lymphoma	Leukemia T-Cell
Leukemia, T-Cell	Leukemia, Acute, Lymphoblastic, T-Cell
Leukemia, T-Cell Acute Lymphoblastic	Leukemia, Acute T-Cell
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Precursor T-Cell Lymphoblastic Lymphoma
Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Leukoencephalopathy With Vanishing White Matter

Cree Leukoencephalopathy	Vanishing White Matter Disease
Ovarioleukodystrophy	Vanishing White Matter Leukodystrophy
Childhood Ataxia With Central Nervous System Hypomyelinization	Cach
Cach Syndrome	Myelinosis Centralis Diffusa
VWM	Cle
Childhood Ataxia With Central Nervous System Hypomyelination	Childhood Ataxia With Diffuse Central Nervous System Hypomyelination
Cach/Vwm	Cach/Vwm Syndrome
Childhood Ataxia With Central Nervous System Hypomyelination/Vanishing White Matter	Cree Leukoencehalopathy
Late Infantile Cach Syndrome	Juvenile Or Adult Cach Syndrome
Congenital Or Early Infantile Cach Syndrome	Leukodystrophy With Vanishing White Matter

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Basal Cell Carcinoma

Basal Cell Cancer	Basal Cell Neoplasm
Basal Cell Carcinoma Of Skin	Malignant Basal Cell Tumor
Basal Cell Tumor	Epithelioma Basal Cell
Malignant Basal Cell Neoplasm	Rodent Ulcer
Carcinoma Basal Cell	Neoplasms, Basal Cell
Basal Cell Carcinomas	Experimental Organism Basal Cell Carcinoma
Nodulo-Ulcerative Basal Cell Carcinoma	Basalioma
Basal Cell Epithelioma Of Skin	Bcc - [Basal Cell Carcinoma] Of Skin
Rodent Ulcer Of Skin	Rodent Ulcer Of Unspecified Site
Basal Cell Epithelioma Of Unspecified Site

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13559	Atiprimod		/	Phase 2

Pre-clinical Phase

Bioactive Molecules (19)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100548	GSK621		98.02%	Unkown
HY-153339	E235	Activator	98.85%	Unkown
HY-158201	ATF4-IN-1	Activator	98.02%	Unkown
HY-153340	I-152	Activator	98.78%	Unkown
HY-124646	KIRA-7	Inhibitor	98.33%	Unkown
HY-153074	ISR-IN-1		98.25%	Unkown
HY-153075	ISR-IN-2		98.21%	Unkown
HY-121337	Flurochloridone		99.61%	Unkown
HY-158202	ATF4-IN-2	Inhibitor	/	Unkown
HY-158203	BMP agonist 2	Agonist	99.26%	Unkown
HY-158204	CNB-001	Inhibitor	/	Unkown
HY-RS01130	ATF4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-149918	Antiproliferative agent-23		/	Unkown
HY-112654A	GCN2iB acetate		/	Unkown
HY-117938	T-3861174	Inhibitor	/	Unkown
HY-158195	DPP23		/	Unkown
HY-158196	PERK/eIF2α activator 1	Activator	/	Unkown
HY-158205	HPO-DAEE		/	Unkown
HY-162886	BSO-07	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ATF4	RGD	RGD:621863
Mus musculus	ATF4	MGD	MGI:88096
Canis familiaris	ATF4	VGNC	VGNC:38210
Bos taurus	ATF4	VGNC	VGNC:26242
Macaca mulatta	ATF4	VGNC	VGNC:107770
Felis catus	ATF4	VGNC	VGNC:68509

Name
Email *

	Sorry, but the email address you supplied was invalid.