SNX20 - sorting nexin 20 Gene

Homo sapiens

Also known as SLIC1

Gene ID: 124460 | Gene type: protein coding

About SNX20

Cytogenetic location: 16q12.1 Genomic coordinates (GRCh38): 16:50,666,300-50,681,312 (from NCBI)

This gene has 4 transcripts (splice variants), 186 orthologues and 1 paralogue. Biased expression in lymph node (RPKM 7.6), appendix (RPKM 6.3) and 12 other tissues.

Summary

SNX20 interacts with the cytoplasmic domain of PSGL1 (SELPLG; MIM 600738) and cycles PSGL1 into endosomes.[supplied by OMIM, Feb 2010]

SNX20 Products(3)

mRNA	Protein	Name
NM_001144972.2	NP_001138444.1	sorting nexin-20 isoform 3
NM_153337.3	NP_699168.1	sorting nexin-20 isoform 2
NM_182854.4	NP_878274.1	sorting nexin-20 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNX20 Protein Structure

0
100
200
316 a.a.

Protein Preferred Names

Protein Names

sorting nexin-20

selectin ligand-interactor cytoplasmic 1

SNX20 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SNX20	Q7Z614	FAM9B	Homo sapiens	Q8IZU0	Y2H Array	31515488
Intra	SNX20	Q7Z614	FAM9B	Homo sapiens	Q8IZU0	Y2H Array	25416956
Intra	SNX20	Q7Z614	SELPLG	Homo sapiens	Q14242	Confocal	18196517
Intra	SNX20	Q7Z614	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	31515488
Intra	SNX20	Q7Z614	TFIP11	Homo sapiens	Q9UBB9	Y2H Prey Pooling	25416956
Intra	SNX20	Q7Z614	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	25416956
Intra	SNX20	Q7Z614	TACC3	Homo sapiens	Q9Y6A5	Y2H Array	25416956
Intra	SNX20	Q7Z614	ALAS1	Homo sapiens	P13196	Y2H Prey Pooling	25416956
Intra	SNX20	Q7Z614	ALAS1	Homo sapiens	P13196	Validated Y2H	25416956
Intra	SNX20	Q7Z614	KLHL12	Homo sapiens	Q53G59	Y2H Prey Pooling	25416956
Intra	SNX20	Q7Z614	KLHL12	Homo sapiens	Q53G59	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Immunodeficiency 73a With Defective Neutrophil Chemotaxis And Leukocytosis

Neutrophil Immunodeficiency Syndrome	IMD73A
Immunodeficiency 73a With Defective Neutrophil Chemotaxix And Leukocytosis	Immunodeficiency, Type 73a, With Defective Neutrophil Chemotaxix And Leukocytosis
Rac 2 Deficiency

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13534	SNX20 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SNX20	MGD	MGI:1918857
Felis catus	SNX20	VGNC	VGNC:65551
Macaca mulatta	SNX20	VGNC	VGNC:77796
Bos taurus	SNX20	VGNC	VGNC:35101
Canis familiaris	SNX20	VGNC	VGNC:46630
Rattus norvegicus	SNX20	RGD	RGD:1307787

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