2. Gene
  3. SNX20 - sorting nexin 20 Gene

SNX20 - sorting nexin 20 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SLIC1

Gene ID: 124460 | Gene type: protein coding

About SNX20

Cytogenetic location: 16q12.1 Genomic coordinates (GRCh38): 16:50,666,300-50,681,312 (from NCBI)

This gene has 4 transcripts (splice variants), 186 orthologues and 1 paralogue. Biased expression in lymph node (RPKM 7.6), appendix (RPKM 6.3) and 12 other tissues.

Summary

SNX20 interacts with the cytoplasmic domain of PSGL1 (SELPLG; MIM 600738) and cycles PSGL1 into endosomes.[supplied by OMIM, Feb 2010]

SNX20 Products(3)

mRNA Protein Name
NM_001144972.2 NP_001138444.1 sorting nexin-20 isoform 3
NM_153337.3 NP_699168.1 sorting nexin-20 isoform 2
NM_182854.4 NP_878274.1 sorting nexin-20 isoform 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNX20 Protein Structure

PX

PX: PX domain (87 - 185)

  • 0
  • 100
  • 200
  • 316 a.a.
Protein Preferred Names Protein Names

sorting nexin-20

selectin ligand-interactor cytoplasmic 1

Related Diseases

Diseases Alias
Immunodeficiency 73a With Defective Neutrophil Chemotaxis And Leukocytosis

Neutrophil Immunodeficiency Syndrome

IMD73A

Immunodeficiency 73a With Defective Neutrophil Chemotaxix And Leukocytosis

Immunodeficiency, Type 73a, With Defective Neutrophil Chemotaxix And Leukocytosis

Rac 2 Deficiency
Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13534 SNX20 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SNX20 MGD MGI:1918857
Felis catus SNX20 VGNC VGNC:65551
Macaca mulatta SNX20 VGNC VGNC:77796
Bos taurus SNX20 VGNC VGNC:35101
Canis familiaris SNX20 VGNC VGNC:46630
Rattus norvegicus SNX20 RGD RGD:1307787