TACC3 - transforming acidic coiled-coil containing protein 3 Gene

Homo sapiens

Also known as ERIC1; Tacc4; ERIC-1; maskin

Gene ID: 10460 | Gene type: protein coding

About TACC3

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:1,721,521-1,745,171 (from NCBI)

This gene has 17 transcripts (splice variants), 199 orthologues, 2 paralogues and is associated with 2 phenotypes. Broad expression in testis (RPKM 25.6), bone marrow (RPKM 24.9) and 16 other tissues.

Summary

This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role in growth a differentiation of certain Cancer cells. [provided by RefSeq, Nov 2011]

TACC3 Products(2)

mRNA	Protein	Name
NM_001410699.1	NP_001397628.1	transforming acidic coiled-coil-containing protein 3 isoform 2
NM_006342.3	NP_006333.1	transforming acidic coiled-coil-containing protein 3 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20360068	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in metaphase/anaphase transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	23532825	GOA
involved in microtubule cytoskeleton organization involved in mitosis	IMP IMP: Inferred from mutant phenotype	23532825	GOA
involved in regulation of mitotic spindle organization	IMP IMP: Inferred from mutant phenotype	21297582	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TACC3 Protein Structure

TACC

0
200
400
600
838 a.a.

Protein Preferred Names

Protein Names

transforming acidic coiled-coil-containing protein 3

TACC3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TACC3	Q9Y6A5	CIB3	Homo sapiens	Q96Q77	Y2H Array	25416956
Intra	TACC3	Q9Y6A5	CIB3	Homo sapiens	Q96Q77	Y2H Array	32296183
Intra	TACC3	Q9Y6A5	CIB3	Homo sapiens	Q96Q77	Y2H Prey Pooling	32296183
Intra	TACC3	Q9Y6A5	CLTA	Homo sapiens	P09496	Anti Bait CoIP	21297582
Intra	TACC3	Q9Y6A5	ASPSCR1	Homo sapiens	Q9BZE9	Validated Y2H	25416956
Intra	TACC3	Q9Y6A5	ASPSCR1	Homo sapiens	Q9BZE9	Y2H Array	25416956
Intra	TACC3	Q9Y6A5	IQCD	Homo sapiens	Q96DY2-2	Y2H Array	32296183
Intra	TACC3	Q9Y6A5	IQCD	Homo sapiens	Q96DY2-2	Y2H Prey Pooling	32296183
Intra	TACC3	Q9Y6A5	VPS37C	Homo sapiens	A5D8V6	Y2H Array	25416956
Intra	TACC3	Q9Y6A5	VPS37C	Homo sapiens	A5D8V6	Validated Y2H	25416956
Intra	TACC3	Q9Y6A5	EGFR	Homo sapiens	P00533	Ub Reconstruction	27956147
Intra	TACC3	Q9Y6A5	EGFR	Homo sapiens	P00533	Anti Tag CoIP	27956147
Intra	TACC3	Q9Y6A5	CKAP5	Homo sapiens	Q14008	Anti Tag CoIP	33961781
Intra	TACC3	Q9Y6A5	CKAP5	Homo sapiens	Q14008	IF	21297582
Intra	TACC3	Q9Y6A5	CKAP5	Homo sapiens	Q14008	Anti Tag CoIP	26496610
Intra	TACC3	Q9Y6A5	CKAP5	Homo sapiens	Q14008	Biochemical	21297582
Intra	TACC3	Q9Y6A5	SNX20	Homo sapiens	Q7Z614	Y2H Prey Pooling	25416956
Intra	TACC3	Q9Y6A5	SNX20	Homo sapiens	Q7Z614	Validated Y2H	25416956
Intra	TACC3	Q9Y6A5	CEP55	Homo sapiens	Q53EZ4	Y2H	27107012
Intra	TACC3	Q9Y6A5	CEP55	Homo sapiens	Q53EZ4	Anti Tag CoIP	33961781
Intra	TACC3	Q9Y6A5	CEP55	Homo sapiens	Q53EZ4	SLC	27107012
Intra	TACC3	Q9Y6A5	TBC1D22B	Homo sapiens	Q9NU19	Y2H Array	29892012
Intra	TACC3	Q9Y6A5	TBC1D22B	Homo sapiens	Q9NU19	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

TACC3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83176	TACC3 Antibody (YA2921)	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Gliosarcoma

Glioblastoma With Sarcomatous Component

Sarcomatous Glioblastoma

Giant Cell Glioblastoma

Monstrocellular Sarcoma

Developmental And Epileptic Encephalopathy 23

DEE23	Epileptic Encephalopathy, Early Infantile, 23
Eiee23	Early-Onset Epileptic Encephalopathy-Cortical Blindness-Intellectual Disability-Facial Dysmorphism Syndrome
Epilepsy-Cortical Blindness-Intellectual Disability-Facial Dysmorphism Syndrome	Developmental And Epileptic Encephalopathy, 23
Early Infantile Epileptic Encephalopathy 23

Thymus Lymphoma

Thymic Lymphoma

Bladder Cancer

Urinary Bladder Cancer	Bladder Carcinoma
Urinary Bladder Carcinoma	Bladder Neoplasm
Bladder Tumor	Cancer, Bladder
Malignant Neoplasm Of Urinary Bladder	Carcinoma Of Bladder
Bladder Cancer, Somatic	Tumor Of The Bladder
Carcinoma Of Urinary Bladder	Bladder Carcinoma Urinary
Cancer Of The Urinary Bladder	Cancer, Urinary Bladder
Malignant Bladder Neoplasm	Malignant Bladder Tumor
Neoplasm Of The Bladder	Neoplasm Of The Urinary Bladder
Tumor Of The Urinary Bladder	Urinary Bladder Neoplasm
BLC	Urothelial Carcinoma Of The Bladder
Bladder Tumors	Urinary Bladder Neoplasms
Bladder Cancer Nos	Vesical Cancer Nos
Malignant Neoplasm Of Bladder, Part Unspecified	Malignant Tumour Of Urinary Bladder
Primary Malignant Neoplasm Of Bladder

Wolf-Hirschhorn Syndrome

Pitt-Rogers-Danks Syndrome	WHS
Chromosome 4p16.3 Deletion Syndrome	Wittwer Syndrome
4p- Syndrome	Pitt Syndrome
4p Deletion Syndrome	Distal Deletion 4p
Distal Monosomy 4p	Telomeric Deletion 4p
Prds	4p Syndrome
Chromosome 4p Syndrome	Microcephaly, Iugr, Hypertelorism, Ptosis, Iris Coloboma, Hooked Nose, External Ear Dysplasia, Psychomotor Retardation
Wolf Syndrome	Chromosome 4p Deletion Syndrome
Chromosome 4p Monosomy	Del Syndrome
Monosomy 4p	Partial Monosomy 4p
Chromosome 4 Short Arm Deletion

Fibrolamellar Carcinoma

Fibrolamellar Hepatocellular Carcinoma	Fhcc
Fibrolamellar Hepatocarcinoma	Hepatocellular Carcinoma, Fibrolamellar
Oncocytic Hepatocellular Tumor	Eosinophilic Glassy Cell Hepatoma
Eosinophilic Hepatocellular Carcinoma With Lamellar Fibrosis	Fl-Hcc
Fibrolamellar Oncocytic Hepatoma	Hepatocellular Carcinoma With Increased Stromal Fibrosis
Polygonal Cell Hepatocellular Carcinoma With Fibrous Stroma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10996A	KHS101 hydrochloride		99.84%	Unkown
HY-135960	BO-264		99.63%	Unkown
HY-120087	KG-548	Inhibitor	99.92%	Unkown
HY-145895	SNIPER(TACC3)-11	Inhibitor	99.58%	Unkown
HY-111876	SNIPER(TACC3)-1		99.51%	Unkown
HY-111877	SNIPER(TACC3)-2		99.81%	Unkown
HY-W012248	KG-655		99.87%	Unkown
HY-10996	KHS101		/	Unkown
HY-111876A	SNIPER(TACC3)-1 hydrochloride		/	Unkown
HY-111877A	SNIPER(TACC3)-2 hydrochloride		/	Unkown
HY-151985	TACC3 inhibitor 1	Inducer	/	Unkown
HY-RS14141	TACC3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TACC3	VGNC	VGNC:53244
Bos taurus	TACC3	VGNC	VGNC:53778
Macaca mulatta	TACC3	VGNC	VGNC:78082
Rattus norvegicus	TACC3	RGD	RGD:1302948
Mus musculus	TACC3	MGD	MGI:1341163
Felis catus	TACC3	VGNC	VGNC:82312

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