Pacsin2 - protein kinase C and casein kinase substrate in neurons 2 Gene

Rattus norvegicus

Also known as SdpII

Gene ID: 124461 | Gene type: protein coding

About Pacsin2

Summary

Predicted to enable cytoskeletal protein binding activity; identical protein binding activity; and phosphatidic acid binding activity. Predicted to be involved in several processes, including caveolin-mediated endocytosis; plasma membrane organization; and protein localization to endosome. Predicted to act upstream of or within negative regulation of endocytosis. Predicted to be located in several cellular components, including caveola; nuclear speck; and recycling endosome membrane. Predicted to be extrinsic component of membrane. Predicted to be active in endosome; glutamatergic synapse; and plasma membrane. Orthologous to human PACSIN2 (protein kinase C and Casein Kinase substrate in neurons 2). [provided by Alliance of Genome Resources, Apr 2022]

Pacsin2 Products(1)

mRNA	Protein	Name
NM_130740.2	NP_570096.2	protein kinase C and casein kinase substrate in neurons 2 protein

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15371016	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein kinase C and casein kinase substrate in neurons 2 protein

SdpIIsyndapin II	synaptic dynamin-associated protein II
syndapin-2	syndapin-II

Pacsin2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Pacsin2	Q9QY17	Cobl	Mus musculus	Q5NBX1	Pull Down	21725280
Cross	Pacsin2	Q9QY17	PDE6G	Homo sapiens	P18545	Y2H	16357825
Cross	Pacsin2	Q9QY17	Ehd4	Mus musculus	Q9EQP2	Pull Down	15371016
Intra	Pacsin2	Q9QY17	Ehd1	Rattus norvegicus	Q641Z6	CoIP	15371016
Cross	Pacsin2	Q9QY17	NCKIPSD	Homo sapiens	Q9NZQ3	Affinity Chrom	16999739
Cross	Pacsin2	Q9QY17	NCKIPSD	Homo sapiens	Q9NZQ3	Pull Down	16999739

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09958	PACSIN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pacsin2	NCBI	NCBI:11252

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