2. Gene
  3. Cd3e - CD3 antigen, epsilon polypeptide Gene

Cd3e - CD3 antigen, epsilon polypeptide Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as CD3; T3e; CD3epsilon

Gene ID: 12501 | Gene type: protein coding

About Cd3e

Summary

Predicted to enable several functions, including SH3 domain binding activity; identical protein binding activity; and protein heterodimerization activity. Involved in nervous system development and positive regulation of cell adhesion. Acts upstream of or within several processes, including positive regulation of T cell activation; positive regulation of cytokine production; and regulation of signal transduction. Located in several cellular components, including dendritic spine; external side of plasma membrane; and immunological synapse. Part of alpha-beta T cell receptor complex. Is expressed in colon and hemolymphoid system. Human ortholog(s) of this gene implicated in immunodeficiency 18. Orthologous to human CD3e (CD3e molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd3e Products(1)

mRNA Protein Name
NM_007648.5 NP_031674.1 T-cell surface glycoprotein CD3 epsilon chain precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
8196616 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of CD4-positive, alpha-beta T cell proliferation IDA
IDA: Inferred from direct assay
8125140 MGI
acts upstream of T cell activation IDA
IDA: Inferred from direct assay
12874832 MGI
acts upstream of T cell anergy IDA
IDA: Inferred from direct assay
14973438 MGI
acts upstream of or within T cell costimulation IGI
IGI: Inferred from genetic interaction
23793062 MGI
acts upstream of T cell proliferation IDA
IDA: Inferred from direct assay
10072077 MGI
acts upstream of or within T cell receptor signaling pathway IDA
IDA: Inferred from direct assay
10485657 MGI
acts upstream of or within apoptotic signaling pathway IDA
IDA: Inferred from direct assay
8666928 MGI
acts upstream of calcium-mediated signaling IDA
IDA: Inferred from direct assay
7630421 MGI
acts upstream of or within cell surface receptor signaling pathway IDA
IDA: Inferred from direct assay
7630421 MGI
involved in cerebellum development IMP
IMP: Inferred from mutant phenotype
17502348 MGI
involved in dendrite development IMP
IMP: Inferred from mutant phenotype
17502348 MGI
acts upstream of interleukin-4 production IDA
IDA: Inferred from direct assay
11894097 MGI
acts upstream of or within lymphocyte activation IMP
IMP: Inferred from mutant phenotype
15843560 MGI
acts upstream of or within negative regulation of smoothened signaling pathway IDA
IDA: Inferred from direct assay
10981962 MGI
acts upstream of or within negative thymic T cell selection IDA
IDA: Inferred from direct assay
7630421 MGI
acts upstream of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
10485657 MGI
acts upstream of or within positive regulation of CD4-positive, alpha-beta T cell proliferation IDA
IDA: Inferred from direct assay
8125140 MGI
acts upstream of or within positive regulation of T cell activation IDA
IDA: Inferred from direct assay
12874832 MGI
acts upstream of or within positive regulation of T cell anergy IDA
IDA: Inferred from direct assay
14973438 MGI
acts upstream of or within positive regulation of T cell proliferation IDA
IDA: Inferred from direct assay
10072077 MGI
acts upstream of or within positive regulation of calcium-mediated signaling IDA
IDA: Inferred from direct assay
7630421 MGI
involved in positive regulation of cell-cell adhesion mediated by integrin IGI
IGI: Inferred from genetic interaction
12652296 MGI
involved in positive regulation of cell-matrix adhesion IGI
IGI: Inferred from genetic interaction
12652296 MGI
acts upstream of or within positive regulation of interleukin-2 production IDA
IDA: Inferred from direct assay
12874832 MGI
acts upstream of or within positive regulation of interleukin-4 production IDA
IDA: Inferred from direct assay
11894097 MGI
acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
10485657 MGI
acts upstream of or within positive regulation of type II interferon production IDA
IDA: Inferred from direct assay
11894097 MGI
acts upstream of smoothened signaling pathway IDA
IDA: Inferred from direct assay
10981962 MGI
acts upstream of type II interferon production IDA
IDA: Inferred from direct assay
11894097 MGI
Cellular Component GO Annotation Evidence Reference Source
part of alpha-beta T cell receptor complex IDA
IDA: Inferred from direct assay
9064344 MGI
located in cell body IDA
IDA: Inferred from direct assay
17502348 MGI
located in cell-cell junction IDA
IDA: Inferred from direct assay
23793062 MGI
located in dendritic spine IDA
IDA: Inferred from direct assay
17502348 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
7630421 MGI
located in immunological synapse IDA
IDA: Inferred from direct assay
14635057 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
17502348 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

T-cell surface glycoprotein CD3 epsilon chain

T-cell surface antigen T3/Leu-4 epsilon chain

Recombinant Cd3e Proteins

Cat. No. Product Name Accession Purity
HY-P71723 CD3 epsilon Protein, Mouse (P.pastoris, His) P22646 (D23-D108) ≥95%
HY-P75414 CD3E-CD3G Heterodimer Protein, Mouse (HEK293, Fc) NP_031674.1 (D23-D108)&NP_033980.1 (Q23-S116) ≥95%
HY-P75415 CD3D-CD3E Heterodimer Protein, Mouse (HEK293, Flag-His) P04235 (F22-A105)&P22646 (D22-D108) ≥95%
HY-P75416 CD3D-CD3E Heterodimer Protein, Mouse (HEK293) P04235 (F22-A105)&P22646 (D22-D108) ≥95%
HY-P77614 CD3D-CD3E Heterodimer Protein, Mouse (HEK293, Fc) P04235 (F22-A105)&P22646 (D23-D108) ≥95%

Related Agents

Approval
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9963 Blinatumomab Inhibitor / Unkown
Clinical Phase
Inhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Phase
HY-P99332 Visilizumab Inducer 98.48% Phase 3
HY-P99798 Pacanalotamab Chemical 97.04% Phase 1
HY-P99868 Duvortuxizumab / Phase 1
Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02243 CD3E Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
Inhibitory Antibodies (20)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99909 Elranatamab / Unkown
HY-P990095 Vonsetamig Inhibitor / Unkown
HY-P990903 Avitotamig Inhibitor / Unkown
HY-P990920 Gocatamig Inhibitor / Unkown
HY-P990925 Linclatamig Inhibitor / Unkown
HY-P990928 Mipletamig Inhibitor / Unkown
HY-P990932 Obrixtamig Inhibitor / Unkown
HY-P990939 Podentamig Inhibitor / Unkown
HY-P990953 Zubotamig Inhibitor / Unkown
HY-P990955 Ebribafusp alfa Inhibitor / Unkown
HY-P990969 Amtabafusp alfa Inhibitor / Unkown
HY-P991015 Pasritamig Inhibitor / Unkown
HY-P991028 Surovatamig Inhibitor / Unkown
HY-P991034 Trevotamig Inhibitor / Unkown
HY-P991036 Velinotamig Inhibitor / Unkown
HY-P99914 Emfizatamab / Unkown
HY-P99916 Emirodatamab / Unkown
HY-P990698 Umizortamig / Unkown
HY-P990759 Rezetamig / Unkown
HY-P99948 Etevritamab / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cd3e NCBI NCBI:916
Canis familiaris Cd3e NCBI NCBI:442981
Macaca fascicularis Cd3e NCBI NCBI:102133065
Rattus norvegicus Cd3e NCBI NCBI:315609
Macaca mulatta Cd3e NCBI NCBI:699467