2. Gene
  3. Cd3e - CD3 epsilon subunit of T-cell receptor complex Gene

Cd3e - CD3 epsilon subunit of T-cell receptor complex Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 315609 | Gene type: protein coding

About Cd3e

Summary

Predicted to enable several functions, including SH3 domain binding activity; identical protein binding activity; and protein heterodimerization activity. Involved in T cell differentiation in thymus; positive regulation of T cell proliferation; and response to nutrient. Predicted to be located in several cellular components, including cell body; dendritic spine; and immunological synapse. Predicted to be part of alpha-beta T cell receptor complex. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in immunodeficiency 18. Orthologous to human CD3e (CD3e molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd3e Products(1)

mRNA Protein Name
NM_001108140.2 NP_001101610.2 T-cell surface glycoprotein CD3 epsilon chain precursor
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in T cell differentiation in thymus IEP
IEP: Inferred from expression pattern
11896936 RGD
involved in positive regulation of T cell proliferation IDA
IDA: Inferred from direct assay
10498748 RGD
involved in response to nutrient IDA
IDA: Inferred from direct assay
10498748 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

T-cell surface glycoprotein CD3 epsilon chain

CD3 antigen, epsilon polypeptide

CD3 molecule, epsilon polypeptide

CD3e molecule

Recombinant Cd3e Proteins

Cat. No. Product Name Accession Purity
HY-P76788 CD3 epsilon Protein, Rat (HEK293, Fc) NP_001101610.1 (Y24-D103) ≥95%

Related Agents

Approval
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9963 Blinatumomab Inhibitor / Unkown
Clinical Phase
Inhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Phase
HY-P99332 Visilizumab Inducer 98.48% Phase 3
HY-P99798 Pacanalotamab Chemical 97.04% Phase 1
HY-P99868 Duvortuxizumab / Phase 1
Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02243 CD3E Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
Inhibitory Antibodies (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99909 Elranatamab / Unkown
HY-P990095 Vonsetamig Inhibitor / Unkown
HY-P99914 Emfizatamab / Unkown
HY-P99916 Emirodatamab / Unkown
HY-P990698 Umizortamig / Unkown
HY-P990759 Rezetamig / Unkown
HY-P99948 Etevritamab / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cd3e NCBI NCBI:916
Canis familiaris Cd3e NCBI NCBI:442981
Macaca fascicularis Cd3e NCBI NCBI:102133065
Mus musculus Cd3e NCBI NCBI:12501
Macaca mulatta Cd3e NCBI NCBI:699467