2. Gene
  3. Cd80 - CD80 antigen Gene

Cd80 - CD80 antigen Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as B71; Ly53; TSA1; Cd28l; Ly-53; MIC17

Gene ID: 12519 | Gene type: protein coding

About Cd80

Summary

Predicted to enable coreceptor activity. Acts upstream of or within T cell costimulation; cellular response to lipopolysaccharide; and positive regulation of alpha-beta T cell proliferation. Located in external side of plasma membrane. Is expressed in heart ventricle and skin. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human CD80 (CD80 molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd80 Products(2)

mRNA Protein Name
NM_001359898.1 NP_001346827.1 T-lymphocyte activation antigen CD80 precursor
NM_009855.2 NP_033985.3 T-lymphocyte activation antigen CD80 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
1385153 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within T cell costimulation IDA
IDA: Inferred from direct assay
1385153 MGI
acts upstream of or within cellular response to lipopolysaccharide IDA
IDA: Inferred from direct assay
19047410 MGI
acts upstream of or within positive regulation of T cell proliferation IGI
IGI: Inferred from genetic interaction
23793062 MGI
acts upstream of or within positive regulation of alpha-beta T cell proliferation IDA
IDA: Inferred from direct assay
1385153 MGI
Cellular Component GO Annotation Evidence Reference Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
1385153 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

T-lymphocyte activation antigen CD80

B7 protein

activation B7-1 antigen

Recombinant Cd80 Proteins

Cat. No. Product Name Accession Purity
HY-P7632 B7-1/CD80 Protein, Mouse (HEK293, Fc) Q00609 (V38-K245) ≥95%
HY-P7633 B7-1/CD80 Protein, Mouse (HEK293, His) Q00609 (V38-N246) ≥95%
HY-P77523 B7-1/CD80 Protein, Mouse (Biotinylated, HEK293, His) Q00609 (V38-K245) ≥95%

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-108813 Belatacept Inhibitor ≥98.0% Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9919 Durvalumab Inhibitor 99.60% Unkown
Clinical Phase
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99293 Galiximab Inhibitor 99.23% Phase 3
HY-P99844 Davoceticept / Phase 1
Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-103048A PD-1/PD-L1-IN 3 TFA Inhibitor 99.34% Unkown
HY-150749A ODN D-SL03 sodium 99.82% Unkown
HY-150749 ODN D-SL03 Inducer 99.82% Unkown
HY-100891 CD80-IN-3 98.08% Unkown
HY-103048 PD-1/PD-L1-IN 3 Inhibitor / Unkown
HY-160227 ORN 06 Activator / Unkown
HY-161833 HSP90-IN-31 Inhibitor / Unkown
HY-RS02269 CD80 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9919A Durvalumab (anti-PD-L1) Inhibitor 99.90% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cd80 NCBI NCBI:941
Macaca fascicularis Cd80 NCBI NCBI:102140078
Leporidae Cd80 NCBI
Rattus norvegicus Cd80 NCBI NCBI:25408
Macaca mulatta Cd80 NCBI NCBI:732518