1. Gene
  2. Cd81 - CD81 antigen Gene

Cd81 - CD81 antigen Gene

Mus musculus

Also known as Tapa1; Tapa-1; Tspan28

Gene ID: 12520 | Gene type: protein coding

About Cd81

Summary

Predicted to enable Cholesterol binding activity; signaling receptor binding activity; and virus receptor activity. Involved in several processes, including cellular response to low-density lipoprotein particle stimulus; positive regulation of immune response; and syncytium formation by plasma membrane fusion. Acts upstream of or within regulation of cell motility. Located in membrane. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in common variable immunodeficiency. Orthologous to human CD81 (CD81 molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd81 Products(1)

mRNA Protein Name
NM_133655.2 NP_598416.1 CD81 antigen
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
11504738 MGI
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to low-density lipoprotein particle stimulus IDA
IDA: Inferred from direct assay
23395392 MGI
involved in macrophage fusion IMP
IMP: Inferred from mutant phenotype
12796480 MGI
involved in myoblast fusion involved in skeletal muscle regeneration IMP
IMP: Inferred from mutant phenotype
23575678 MGI
involved in osteoclast fusion IMP
IMP: Inferred from mutant phenotype
12796480 MGI
involved in positive regulation of B cell activation IMP
IMP: Inferred from mutant phenotype
23499492 MGI
involved in positive regulation of B cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
23499492 MGI
involved in positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IMP
IMP: Inferred from mutant phenotype
11046035 MGI
involved in positive regulation of T-helper 2 cell cytokine production IMP
IMP: Inferred from mutant phenotype
11046035 MGI
involved in positive regulation of inflammatory response to antigenic stimulus IMP
IMP: Inferred from mutant phenotype
11046035 MGI
involved in positive regulation of receptor clustering IMP
IMP: Inferred from mutant phenotype
23499492 MGI
involved in receptor internalization IDA
IDA: Inferred from direct assay
23395392 MGI
acts upstream of or within regulation of cell motility IGI
IGI: Inferred from genetic interaction
11673522 MGI
involved in regulation of macrophage migration IDA
IDA: Inferred from direct assay
18662991 MGI
Cellular Component GO Annotation Evidence Reference Source
located in membrane IDA
IDA: Inferred from direct assay
23395392 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

CD81 antigen

26 kDa cell surface protein TAPA-1

target of the antiproliferative antibody 1

Recombinant Cd81 Proteins

Cat. No. Product Name Accession Purity
HY-P74262 CD81 Protein, Mouse (HEK293, His) P35762 (K116-K201) ≥95%
HY-P74263 CD81 Protein, Mouse (HEK293, Fc) P35762 (K116-K201) ≥95%

Orthologs Information

Species Symbol Source ID
Homo sapiens Cd81 NCBI NCBI:975
Rattus norvegicus Cd81 NCBI NCBI:25621
Macaca mulatta Cd81 NCBI NCBI:704961