Cd81 - CD81 antigen Gene

Mus musculus

Also known as Tapa1; Tapa-1; Tspan28

Gene ID: 12520 | Gene type: protein coding

About Cd81

Summary

Predicted to enable Cholesterol binding activity; signaling receptor binding activity; and virus receptor activity. Involved in several processes, including cellular response to low-density lipoprotein particle stimulus; positive regulation of immune response; and syncytium formation by plasma membrane fusion. Acts upstream of or within regulation of cell motility. Located in membrane. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in common variable immunodeficiency. Orthologous to human CD81 (CD81 molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd81 Products(1)

mRNA	Protein	Name
NM_133655.2	NP_598416.1	CD81 antigen

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11504738	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to low-density lipoprotein particle stimulus	IDA IDA: Inferred from direct assay	23395392	MGI
involved in macrophage fusion	IMP IMP: Inferred from mutant phenotype	12796480	MGI
involved in myoblast fusion involved in skeletal muscle regeneration	IMP IMP: Inferred from mutant phenotype	23575678	MGI
involved in osteoclast fusion	IMP IMP: Inferred from mutant phenotype	12796480	MGI
involved in positive regulation of B cell activation	IMP IMP: Inferred from mutant phenotype	23499492	MGI
involved in positive regulation of B cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	23499492	MGI
involved in positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	IMP IMP: Inferred from mutant phenotype	11046035	MGI
involved in positive regulation of T-helper 2 cell cytokine production	IMP IMP: Inferred from mutant phenotype	11046035	MGI
involved in positive regulation of inflammatory response to antigenic stimulus	IMP IMP: Inferred from mutant phenotype	11046035	MGI
involved in positive regulation of receptor clustering	IMP IMP: Inferred from mutant phenotype	23499492	MGI
involved in receptor internalization	IDA IDA: Inferred from direct assay	23395392	MGI
acts upstream of or within regulation of cell motility	IGI IGI: Inferred from genetic interaction	11673522	MGI
involved in regulation of macrophage migration	IDA IDA: Inferred from direct assay	18662991	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IDA IDA: Inferred from direct assay	23395392	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

CD81 antigen

26 kDa cell surface protein TAPA-1

target of the antiproliferative antibody 1

Recombinant Cd81 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74262	CD81 Protein, Mouse (HEK293, His)	P35762 (K116-K201)	≥95%
HY-P74263	CD81 Protein, Mouse (HEK293, Fc)	P35762 (K116-K201)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02270	CD81 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-N2940	Bisandrographolide A	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cd81	NCBI	NCBI:975
Rattus norvegicus	Cd81	NCBI	NCBI:25621
Macaca mulatta	Cd81	NCBI	NCBI:704961

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