2. Gene
  3. CD81 - CD81 molecule Gene

CD81 - CD81 molecule Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as S5.7; CVID6; TAPA1; TSPAN28

Gene ID: 975 | Gene type: protein coding

About CD81

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:2,376,180-2,397,397 (from NCBI)

This gene has 17 transcripts (splice variants), 266 orthologues, 32 paralogues and is associated with 2 phenotypes. Ubiquitous expression in endometrium (RPKM 241.8), fat (RPKM 237.1) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

CD81 Products(2)

mRNA Protein Name
NM_001297649.2 NP_001284578.1 CD81 antigen isoform 2
NM_004356.4 NP_004347.1 CD81 antigen isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables MHC class II protein binding IDA
IDA: Inferred from direct assay
8409388 GOA
enables cholesterol binding IDA
IDA: Inferred from direct assay
27881302 GOA
enables integrin binding IDA
IDA: Inferred from direct assay
12796480 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
2398277 GOA
enables transferrin receptor binding IPI
IPI: Inferred from physical interaction
25635054 GOA
enables virus receptor activity IMP
IMP: Inferred from mutant phenotype
20375010 GOA
Biological Process GO Annotation Evidence Reference Source
involved in CD4-positive, alpha-beta T cell costimulation IDA
IDA: Inferred from direct assay
22307619 GOA
involved in humoral immune response mediated by circulating immunoglobulin IMP
IMP: Inferred from mutant phenotype
20237408 GOA
involved in immunological synapse formation IMP
IMP: Inferred from mutant phenotype
23858057 GOA
involved in macrophage fusion IDA
IDA: Inferred from direct assay
12796480 GOA
involved in positive regulation of B cell proliferation IDA
IDA: Inferred from direct assay
10400713 GOA
involved in positive regulation of B cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
20237408 GOA
involved in positive regulation of CD4-positive, alpha-beta T cell proliferation IDA
IDA: Inferred from direct assay
22307619 GOA
involved in positive regulation of MAPK cascade IDA
IDA: Inferred from direct assay
14676841 GOA
involved in positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IDA
IDA: Inferred from direct assay
8766544 GOA
involved in positive regulation of T cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
23858057 GOA
involved in positive regulation of T-helper 2 cell cytokine production IDA
IDA: Inferred from direct assay
8766544 GOA
involved in positive regulation of adaptive immune memory response IMP
IMP: Inferred from mutant phenotype
20237408 GOA
involved in positive regulation of protein catabolic process in the vacuole IMP
IMP: Inferred from mutant phenotype
25635054 GOA
involved in positive regulation of protein exit from endoplasmic reticulum IMP
IMP: Inferred from mutant phenotype
16449649 GOA
involved in positive regulation of receptor clustering IDA
IDA: Inferred from direct assay
23858057 GOA
involved in positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
25635054 GOA
involved in protein localization to lysosome IMP
IMP: Inferred from mutant phenotype
25635054 GOA
involved in protein localization to plasma membrane IDA
IDA: Inferred from direct assay
14676841 GOA
involved in protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
20237408 GOA
involved in regulation of protein stability IMP
IMP: Inferred from mutant phenotype
25635054 GOA
Cellular Component GO Annotation Evidence Reference Source
located in basal plasma membrane IDA
IDA: Inferred from direct assay
31791063 GOA
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
20375010 GOA
located in extracellular exosome IDA
IDA: Inferred from direct assay
15908444 GOA
located in immunological synapse IDA
IDA: Inferred from direct assay
21930792 GOA
located in membrane IDA
IDA: Inferred from direct assay
27881302 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
8409388 GOA
located in tetraspanin-enriched microdomain IDA
IDA: Inferred from direct assay
28871089 GOA
located in vesicle IDA
IDA: Inferred from direct assay
9360996 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD81 Protein Structure

Tetraspannin

Tetraspannin: Tetraspanin family (9 - 229)

  • 0
  • 100
  • 200
  • 236 a.a.
Protein Preferred Names Protein Names

CD81 antigen

26 kDa cell surface protein TAPA-1

CD81 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CD81 P60033 MCEE Homo sapiens Q96PE7
Validated Y2H
32296183
Intra
CD81 P60033 MCEE Homo sapiens Q96PE7
Y2H Array
32296183
Intra
CD81 P60033 MCEE Homo sapiens Q96PE7
Y2H Prey Pooling
32296183
Intra
CD81 P60033 LBR Homo sapiens Q14739
Validated Y2H
32296183
Intra
CD81 P60033 LBR Homo sapiens Q14739
Y2H Array
32296183
Intra
CD81 P60033 LBR Homo sapiens Q14739
Y2H Prey Pooling
32296183
Intra
CD81 P60033 NEMP1 Homo sapiens O14524-2
Y2H Prey Pooling
32296183
Intra
CD81 P60033 NEMP1 Homo sapiens O14524-2
Y2H Array
32296183
Intra
CD81 P60033 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra
CD81 P60033 GPX8 Homo sapiens Q8TED1
Validated Y2H
32296183
Intra
CD81 P60033 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra
CD81 P60033 SLC26A6 Homo sapiens Q9BXS9-3
Y2H Prey Pooling
32296183
Intra
CD81 P60033 SLC26A6 Homo sapiens Q9BXS9-3
Validated Y2H
32296183
Intra
CD81 P60033 SLC26A6 Homo sapiens Q9BXS9-3
Y2H Array
32296183
Intra
CD81 P60033 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
CD81 P60033 AQP6 Homo sapiens Q13520
Validated Y2H
32296183
Intra
CD81 P60033 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
CD81 P60033 GPR152 Homo sapiens Q8TDT2
Validated Y2H
32296183
Intra
CD81 P60033 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra
CD81 P60033 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra
CD81 P60033 ADAM10 Homo sapiens O14672
Anti Bait CoIP
23091066
Intra
CD81 P60033 ADAM10 Homo sapiens O14672
Anti Bait CoIP
32900848
Intra
CD81 P60033 ADAM10 Homo sapiens O14672
Anti Bait CoIP
19587294
Intra
CD81 P60033 TREX1 Homo sapiens Q9NSU2-1
Validated Y2H
32296183
Intra
CD81 P60033 SDHAF4 Homo sapiens Q5VUM1
Validated Y2H
32296183
Intra
CD81 P60033 SDHAF4 Homo sapiens Q5VUM1
Y2H Array
32296183
Intra
CD81 P60033 SDHAF4 Homo sapiens Q5VUM1
Y2H Prey Pooling
32296183
Intra
CD81 P60033 CPLX4 Homo sapiens Q7Z7G2
Validated Y2H
32296183
Intra
CD81 P60033 CPLX4 Homo sapiens Q7Z7G2
Y2H Array
32296183
Intra
CD81 P60033 CPLX4 Homo sapiens Q7Z7G2
Y2H Prey Pooling
32296183
Intra
CD81 P60033 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra
CD81 P60033 FAM209A Homo sapiens Q5JX71
Validated Y2H
32296183
Intra
CD81 P60033 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
CD81 P60033 O14672-PRO_0000029067 Homo sapiens O14672-PRO_0000029067
Anti Tag CoIP
19587294
Intra
CD81 P60033 BST2 Homo sapiens Q10589
Validated Y2H
32296183
Intra
CD81 P60033 BST2 Homo sapiens Q10589
Y2H Prey Pooling
32296183
Intra
CD81 P60033 BST2 Homo sapiens Q10589
Y2H Array
32296183
Intra
CD81 P60033 LHFPL5 Homo sapiens Q8TAF8
Y2H Prey Pooling
32296183
Intra
CD81 P60033 LHFPL5 Homo sapiens Q8TAF8
Validated Y2H
32296183
Intra
CD81 P60033 LHFPL5 Homo sapiens Q8TAF8
Y2H Array
32296183
Intra
CD81 P60033 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra
CD81 P60033 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra
CD81 P60033 EBP Homo sapiens Q15125
Validated Y2H
32296183
Intra
CD81 P60033 GORAB Homo sapiens Q5T7V8
Validated Y2H
32296183
Intra
CD81 P60033 GORAB Homo sapiens Q5T7V8
Y2H Array
32296183
Intra
CD81 P60033 GORAB Homo sapiens Q5T7V8
Y2H Prey Pooling
32296183
Intra
CD81 P60033 SAR1A Homo sapiens Q9NR31
Validated Y2H
32296183
Intra
CD81 P60033 SAR1A Homo sapiens Q9NR31
Y2H Prey Pooling
32296183
Intra
CD81 P60033 SAR1A Homo sapiens Q9NR31
Y2H Array
32296183
Intra
CD81 P60033 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra
CD81 P60033 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra
CD81 P60033 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra
CD81 P60033 GJA4 Homo sapiens P35212
Y2H Prey Pooling
32296183
Intra
CD81 P60033 GJA4 Homo sapiens P35212
Y2H Array
32296183
Intra
CD81 P60033 STX1A Homo sapiens Q16623
Validated Y2H
32296183
Intra
CD81 P60033 STX1A Homo sapiens Q16623
Y2H Prey Pooling
32296183
Intra
CD81 P60033 STX1A Homo sapiens Q16623
Y2H Array
32296183
Intra
CD81 P60033 PDZK1IP1 Homo sapiens Q13113
Y2H Array
32296183
Intra
CD81 P60033 PDZK1IP1 Homo sapiens Q13113
Y2H Prey Pooling
32296183
Intra
CD81 P60033 PDZK1IP1 Homo sapiens Q13113
Validated Y2H
32296183
Intra
CD81 P60033 THAP4 Homo sapiens Q8WY91
Y2H Prey Pooling
32296183
Intra
CD81 P60033 THAP4 Homo sapiens Q8WY91
Validated Y2H
32296183
Intra
CD81 P60033 THAP4 Homo sapiens Q8WY91
Y2H Array
32296183
Intra
CD81 P60033 MRPS18B Homo sapiens Q9Y676
Y2H Prey Pooling
32296183
Intra
CD81 P60033 MRPS18B Homo sapiens Q9Y676
Y2H Array
32296183
Intra
CD81 P60033 MRPS18B Homo sapiens Q9Y676
Validated Y2H
32296183
Intra
CD81 P60033 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
CD81 P60033 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
CD81 P60033 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
CD81 P60033 SCARB1 Homo sapiens Q8WTV0
Anti Bait CoIP
30024968
Cross
CD81 P60033 Q99IB8-PRO_0000045596 Hepatitis C virus Q99IB8-PRO_0000045596
Pull Down
19088272
Cross
CD81 P60033 P27958-PRO_0000037570 Hepatitis C virus P27958-PRO_0000037570
FACS
10400713
Cross
CD81 P60033 P27958-PRO_0000037570 Hepatitis C virus P27958-PRO_0000037570
Far-WB
9794763
Cross
CD81 P60033 P27958-PRO_0000037570 Hepatitis C virus P27958-PRO_0000037570
Far-WB
12522210
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD81 Proteins

Cat. No. Product Name Accession Purity
HY-P72126 CD81 Protein, Human (His-SUMO) P60033 (F113-K201) ≥95%
HY-P72706 CD81 Protein, Human (HEK293, Fc) P60033 (F113-K201) ≥95%
HY-P74264 CD81 Protein, Human (HEK293, His) P60033 (F113-K201) ≥95%

CD81 Antibodies

Cat. No. Product Name Application Reactivity
HY-P80608 CD81 Antibody WB, IHC-F, IHC-P, ICC/IF Human, Mouse

Related Diseases

Diseases Alias
Immunodeficiency, Common Variable, 6

CVID6

Antibody Deficiency Due To Cd81 Defect

Common Variable Immunodeficiency 6

Immunodeficiency, Variable, Common, Type 6
Common Variable Immunodeficiency

Cvid

Common Variable Agammaglobulinemia

Common Variable Immune Deficiency

Acquired Hypogammaglobulinemia

Hypogamma-Globulinemia, Acquired

Idiopathic Immunoglobulin Deficiency

Primary Antibody Deficiency

Primary Hypogammaglobulinemia

Acquired Agammaglobulinemia

Sporadic Hypogammaglobulinemia

Common Variable Hypogamma-Globulinemia

Immunoglobulin Deficiency, Late-Onset

Common Variable Hypogammaglobulinemia

Immunodeficiency, Common Variable
Hepatitis C

Chronic Hepatitis C

Hepatitis C Infection

Hepatitis Nona Nonb

Nanbh

Viral Hepatitis C

Hepatitis C Chronic

Hepatitis C, Chronic

Chronic Type C Viral Hepatitis

Chronic Hcv - [Hepatitis C Virus] Infection

Hepatitis C Nos

Hepatitis C Infection Nos

Hepatitis C-Related Cirrhosis

Type C Viral Hepatitis

Hep C Nos
Cryoglobulinemia

Cryoimmunoglobulinaemia
Hepatitis C Virus

Hepatitis C Virus, Susceptibility To

Hepatitis C Virus Infection, Response To Therapy Of

Hcv

Hcv, Susceptibility To

Hepatitis C Virus, Resistance To

Hepatitis C Virus, Response To Therapy Of

Resistance To Hepatitis C Virus
Viral Infectious Disease

Viral Disease

Arbovirus Infections

Virus Infection

Virus Diseases

Viral Infection

Viral Infections

Virus Infections
Malaria

Malaria, Susceptibility To

Malaria, Resistance To

Malaria, Cerebral

Cerebral Malaria

Malaria, Severe, Susceptibility To

Malaria, Severe, Resistance To

Malaria, Cerebral, Susceptibility To

Induced Malaria

Malaria, Vivax, Protection Against

Malaria, Severe

Malaria, Cerebral, Reduced Risk Of

Malaria, Protection Against

Resistance To Malaria Due To G6pd Deficiency

Malaria Due To G6pd Deficiency

Malarial Encephalitis

CM

Malaria Cerebral

Susceptibility To Malaria

Acute Pernicious Fever

Aestivo-Autumnal Fever

Aestivo Autumnal Malaria

Chagres Fever

Continued Malaria Fever

Estivo-Autumnal Fever

Estivo-Autumnal Malaria

Estivo-Autumnal Malarial Fever

Falciparum Fever

Malignant Tertian Fever

Malignant Tertian Malaria

Pernicious Intermittent Fever

Pernicious Malaria

Quotidian Malaria

Subtertian Fever

Subtertian Malaria Fever

Subtertian Malignant Tertian Malaria

Tropical Malaria

Algid Malaria

Bilious Haemoglobinuric Fever

Black Water Fever

Blackwater Fever

Malarial Blackwater Fever

Severe Malarial Falciparum

West African Fever

Malarial Haematinuria

Haemoglobinuric Fever

Haemoglobinuric Malaria

Severe Plasmodium Falciparum Malaria

Malarial Haemoglobinuria

Malarial Haematuria

Falciparum Malaria [Malignant Tertian]

Malaria Tropica

Malarial Shock

Chagres Virus Disease

Malignant Malaria

Mtm - [Malignant Tertian Malaria]

Tm -[Malignant Tertian Malaria]

Panama Fever

St - [Subtertian Malaria]

Malarial Quotidian

Benign Tertian Malaria

Tertian Ague

Vivax Fever

Plasmodium Vivax Malaria Nos

Btm - [Benign Tertian Malaria]

Bt - [Benign Tertian Malaria]

Vivax Malaria

Benign Tertian Vivax Malaria

Tertian Malaria

Quartan Malaria

Quartan Ague

Quartan Fever

Plasmodium Malariae Malaria Nos

Quartan Malarial

Malaria By Plasmodium Malariae

Malariae Malaria

Ovale Tertian Malaria

Plasmodium Ovale Fever

Malaria Fever By Plasmodium Ovale

Ovale Malaria

Malaria By Plasmodium Ovale

Malarial Ovale

Marsh Fever

Remittent Congestive Fever

Coastal Fever

Remittent Gastric Fever

Miasmatic Fever

Congestive Remittent Fever

Intermittent Fever

Jungle Fever

Paludism

Cameroon Fever

Ague

Corsican Fever

Intermittent Bilious Fever

Disease Due To Plasmodiidae

Malarial Fever

Plasmodiosis

Remittent Fever

Roman Fever

Malaria Fever Nos

Malaria Nos

Paludal Fever

Clinically Diagnosed Malaria

Clinically Diagnosed Malaria Without Parasitological Confirmation

Congestive Fever

Malarial Cachexia

Marsh Cachexia

Paludal Cachexia

Recurrent Malaria

Remittent Malaria
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Immune Deficiency Disease

Immunodeficiency

Primary Immunodeficiency

Primary Immunodeficiency Disease

Immunologic Deficiency Syndromes

Hypoimmunity

Immune Deficiency Disorder

Immunodeficiency Syndrome

Immune Disorder

Primary Immune Deficiency Disorder

Immune System Diseases

Human Immunodeficiency Virus Infection

Hiv - [Human Immunodeficiency Virus Infection]

Hiv Positive Nos

Hiv Disease

Acquired Immune Deficiency Syndrome-Related Complex

Aids-Like Syndrome

Aids-Related Complex Nos

Arc - [Aids-Related Complex]

Immunodeficiency Due To Human Immunodeficiency Virus Infection

Unspecified Human Immunodeficiency Virus Disease

Hiv Disease Nos

Human Immunodeficiency Virus Positive Nos

Hiv Nos

Deficiency Of Complement Initial Pathway

Deficiency Of Complement Terminal Pathway

Cfdd - [Complement Factor D Deficiency]

Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency

Nonfamilial Hypogammaglobulinaemia

Common Variable Immune Deficiency

Nonfamilial Agammaglobulinaemia

Common Variable Agammaglobulinaemia

Agammaglobulinaemia Nos

Agammaglobulinaemia Antibody Deficiency Syndrome

Hypogammaglobulinaemia Antibody Deficiency Syndrome

Acquired Agammaglobulinaemia Nos

Hypogammaglobulinaemia Nos

Hyper Igm
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02270 CD81 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-N2940 Bisandrographolide A Activator / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CD81 VGNC VGNC:70780
Bos taurus CD81 VGNC VGNC:50034
Mus musculus CD81 MGD MGI:1096398
Rattus norvegicus CD81 RGD RGD:2315
Felis catus CD81 VGNC VGNC:60640
Canis familiaris CD81 VGNC VGNC:49705
Others CD81 NCBI