TNFAIP8L1 - TNF alpha induced protein 8 like 1 Gene

Homo sapiens

Also known as TIPE1

Gene ID: 126282 | Gene type: protein coding

About TNFAIP8L1

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:4,639,516-4,655,568 (from NCBI)

This gene has 3 transcripts (splice variants), 185 orthologues and 3 paralogues. Ubiquitous expression in liver (RPKM 6.4), spleen (RPKM 5.8) and 24 other tissues.

Summary

Enables identical protein binding activity. Predicted to be involved in negative regulation of TOR signaling. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

TNFAIP8L1 Products(2)

mRNA	Protein	Name
NM_001167942.1	NP_001161414.1	tumor necrosis factor alpha-induced protein 8-like protein 1
NM_152362.3	NP_689575.2	tumor necrosis factor alpha-induced protein 8-like protein 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNFAIP8L1 Protein Structure

DUF758

0
100
186 a.a.

Protein Preferred Names

Protein Names

tumor necrosis factor alpha-induced protein 8-like protein 1

TNF alpha-induced protein 8-like protein 1

TNFAIP8L1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TNFAIP8L1	Q8WVP5	ANKRD36B	Homo sapiens	Q8N2N9-4	Y2H Array	32296183
Intra	TNFAIP8L1	Q8WVP5	ANKRD36B	Homo sapiens	Q8N2N9-4	Y2H Prey Pooling	32296183
Intra	TNFAIP8L1	Q8WVP5	CAVIN1	Homo sapiens	Q6NZI2	Y2H Array	32296183
Intra	TNFAIP8L1	Q8WVP5	CAVIN1	Homo sapiens	Q6NZI2	Y2H Prey Pooling	32296183
Intra	TNFAIP8L1	Q8WVP5	PSME3	Homo sapiens	P61289	Y2H Array	32296183
Intra	TNFAIP8L1	Q8WVP5	PSME3	Homo sapiens	P61289	Y2H Prey Pooling	25416956
Intra	TNFAIP8L1	Q8WVP5	PSME3	Homo sapiens	P61289	Y2H Prey Pooling	32296183
Intra	TNFAIP8L1	Q8WVP5	MED4	Homo sapiens	Q9NPJ6	Y2H Prey Pooling	32296183
Intra	TNFAIP8L1	Q8WVP5	MED4	Homo sapiens	Q9NPJ6	Validated Y2H	32296183
Intra	TNFAIP8L1	Q8WVP5	MED4	Homo sapiens	Q9NPJ6	Y2H Array	32296183
Intra	TNFAIP8L1	Q8WVP5	DVL3	Homo sapiens	Q92997	Y2H Array	32296183
Intra	TNFAIP8L1	Q8WVP5	DVL3	Homo sapiens	Q92997	Y2H Prey Pooling	32296183
Intra	TNFAIP8L1	Q8WVP5	DVL3	Homo sapiens	Q92997	Validated Y2H	32296183
Intra	TNFAIP8L1	Q8WVP5	PLEKHF2	Homo sapiens	Q9H8W4	Validated Y2H	32296183
Intra	TNFAIP8L1	Q8WVP5	STAC3	Homo sapiens	Q96MF2	Y2H Array	32296183
Intra	TNFAIP8L1	Q8WVP5	STAC3	Homo sapiens	Q96MF2	Validated Y2H	32296183
Intra	TNFAIP8L1	Q8WVP5	STAC3	Homo sapiens	Q96MF2	Y2H Prey Pooling	32296183
Intra	TNFAIP8L1	Q8WVP5	EVI5	Homo sapiens	O60447	Y2H Prey Pooling	32296183
Intra	TNFAIP8L1	Q8WVP5	EVI5	Homo sapiens	O60447	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Colon Mucinous Adenocarcinoma

Colonic Mucinous Adenocarcinoma

Mucinous Adenocarcinoma Of The Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14792	TNFAIP8L1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TNFAIP8L1	RGD	RGD:1588574
Bos taurus	TNFAIP8L1	VGNC	VGNC:36158
Felis catus	TNFAIP8L1	VGNC	VGNC:66400
Macaca mulatta	TNFAIP8L1	VGNC	VGNC:79694
Mus musculus	TNFAIP8L1	MGD	MGI:1913693

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