MED4 - mediator complex subunit 4 Gene

Homo sapiens

Also known as ARC36; VDRIP; DRIP36; TRAP36; HSPC126

Gene ID: 29079 | Gene type: protein coding

About MED4

Cytogenetic location: 13q14.2 Genomic coordinates (GRCh38): 13:48,075,724-48,095,104 (from NCBI)

This gene has 4 transcripts (splice variants) and 221 orthologues. Ubiquitous expression in testis (RPKM 13.4), bone marrow (RPKM 12.6) and 25 other tissues.

Summary

This gene encodes a component of the Mediator complex. The Mediator complex interacts with DNA-binding gene-specific transcription factors to modulate transcription by RNA polymerase II. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

MED4 Products(2)

mRNA	Protein	Name
NM_001270629.2	NP_001257558.1	mediator of RNA polymerase II transcription subunit 4 isoform 2
NM_014166.4	NP_054885.1	mediator of RNA polymerase II transcription subunit 4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14638676	GOA
enables transcription coregulator activity	IDA IDA: Inferred from direct assay	10882111	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10882111	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of core mediator complex	IPI IPI: Inferred from physical interaction	24882805	GOA
part of mediator complex	IDA IDA: Inferred from direct assay	10882111	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10235267	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MED4 Protein Structure

Med4

0
100
200
270 a.a.

Protein Preferred Names

Protein Names

mediator of RNA polymerase II transcription subunit 4

activator-recruited cofactor 36 kDa component

MED4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MED4	Q9NPJ6	CCHCR1	Homo sapiens	Q8TD31-3	Validated Y2H	25416956
Intra	MED4	Q9NPJ6	FTCD	Homo sapiens	O95954	Validated Y2H	25416956
Intra	MED4	Q9NPJ6	FTCD	Homo sapiens	O95954	Y2H Prey Pooling	25416956
Intra	MED4	Q9NPJ6	CCDC146	Homo sapiens	Q8IYE0-2	Y2H Array	25416956
Intra	MED4	Q9NPJ6	MAB21L3	Homo sapiens	Q8N8X9	Y2H Array	25416956
Intra	MED4	Q9NPJ6	MAB21L3	Homo sapiens	Q8N8X9	Y2H Prey Pooling	25416956
Intra	MED4	Q9NPJ6	SSX3	Homo sapiens	Q99909	Validated Y2H	25416956
Intra	MED4	Q9NPJ6	TNFAIP8	Homo sapiens	O95379	Y2H Array	25416956
Intra	MED4	Q9NPJ6	KIFC3	Homo sapiens	Q9BVG8	Validated Y2H	25416956
Intra	MED4	Q9NPJ6	HAUS1	Homo sapiens	Q96CS2	Validated Y2H	25416956
Intra	MED4	Q9NPJ6	HAUS1	Homo sapiens	Q96CS2	Y2H Array	25416956
Intra	MED4	Q9NPJ6	HAUS1	Homo sapiens	Q96CS2	BioID	25281560
Intra	MED4	Q9NPJ6	SMARCD1	Homo sapiens	Q96GM5	Validated Y2H	25416956
Intra	MED4	Q9NPJ6	SMARCD1	Homo sapiens	Q96GM5	Y2H Array	25416956
Intra	MED4	Q9NPJ6	TXLNA	Homo sapiens	P40222	Validated Y2H	25416956
Intra	MED4	Q9NPJ6	TXLNA	Homo sapiens	P40222	Y2H Prey Pooling	25416956
Intra	MED4	Q9NPJ6	TXLNA	Homo sapiens	P40222	BioID	25281560
Intra	MED4	Q9NPJ6	TXLNA	Homo sapiens	P40222	Pull Down	25281560
Intra	MED4	Q9NPJ6	AMOT	Homo sapiens	Q4VCS5-2	Y2H Prey Pooling	25416956
Intra	MED4	Q9NPJ6	AMOT	Homo sapiens	Q4VCS5-2	Y2H Array	25416956
Intra	MED4	Q9NPJ6	MED12	Homo sapiens	Q93074	BioID	25281560
Intra	MED4	Q9NPJ6	MED12	Homo sapiens	Q93074	Pull Down	25281560
Intra	MED4	Q9NPJ6	MED12	Homo sapiens	Q93074	Anti Tag CoIP	35271311
Intra	MED4	Q9NPJ6	MED12	Homo sapiens	Q93074	Anti Tag CoIP	33961781
Intra	MED4	Q9NPJ6	MED12	Homo sapiens	Q93074	Anti Bait CoIP	21293490
Intra	MED4	Q9NPJ6	MED26	Homo sapiens	O95402	Anti Tag CoIP	35271311
Intra	MED4	Q9NPJ6	MED26	Homo sapiens	O95402	Anti Tag CoIP	33961781
Intra	MED4	Q9NPJ6	MED26	Homo sapiens	O95402	Anti Tag CoIP	24882805
Intra	MED4	Q9NPJ6	MED26	Homo sapiens	O95402	BioID	25281560
Intra	MED4	Q9NPJ6	MED26	Homo sapiens	O95402	Pull Down	25281560
Intra	MED4	Q9NPJ6	MED9	Homo sapiens	Q9NWA0	Anti Tag CoIP	33961781
Intra	MED4	Q9NPJ6	MED9	Homo sapiens	Q9NWA0	Pull Down	14638676
Intra	MED4	Q9NPJ6	MED9	Homo sapiens	Q9NWA0	BioID	25281560
Intra	MED4	Q9NPJ6	MED9	Homo sapiens	Q9NWA0	Anti Tag CoIP	14638676
Intra	MED4	Q9NPJ6	MED9	Homo sapiens	Q9NWA0	Anti Tag CoIP	35271311
Intra	MED4	Q9NPJ6	MED9	Homo sapiens	Q9NWA0	Pull Down	25281560
Intra	MED4	Q9NPJ6	MED21	Homo sapiens	Q13503	Pull Down	25281560
Intra	MED4	Q9NPJ6	MED21	Homo sapiens	Q13503	Anti Tag CoIP	33961781
Intra	MED4	Q9NPJ6	MED21	Homo sapiens	Q13503	BioID	25281560
Intra	MED4	Q9NPJ6	MED21	Homo sapiens	Q13503	Anti Tag CoIP	35271311
Intra	MED4	Q9NPJ6	NDC80	Homo sapiens	O14777	Y2H Array	25416956
Intra	MED4	Q9NPJ6	NDC80	Homo sapiens	O14777	BioID	25281560
Intra	MED4	Q9NPJ6	NDC80	Homo sapiens	O14777	Y2H Prey Pooling	25416956
Intra	MED4	Q9NPJ6	TLE5	Homo sapiens	Q08117	Y2H Prey Pooling	25416956
Intra	MED4	Q9NPJ6	TLE5	Homo sapiens	Q08117	Validated Y2H	25416956
Intra	MED4	Q9NPJ6	TLE5	Homo sapiens	Q08117	Y2H Array	25416956
Intra	MED4	Q9NPJ6	USHBP1	Homo sapiens	Q8N6Y0	Validated Y2H	25416956
Intra	MED4	Q9NPJ6	IFT20	Homo sapiens	Q8IY31	Y2H Prey Pooling	25416956
Intra	MED4	Q9NPJ6	IFT20	Homo sapiens	Q8IY31	Validated Y2H	25416956
Intra	MED4	Q9NPJ6	IFT20	Homo sapiens	Q8IY31	Y2H Array	25416956
Intra	MED4	Q9NPJ6	IFT20	Homo sapiens	Q8IY31	Pull Down	25281560
Intra	MED4	Q9NPJ6	C1orf216	Homo sapiens	Q8TAB5	Validated Y2H	25416956
Intra	MED4	Q9NPJ6	C1orf216	Homo sapiens	Q8TAB5	Y2H Prey Pooling	25416956
Intra	MED4	Q9NPJ6	FAM13C	Homo sapiens	Q8NE31	Y2H Prey Pooling	25416956
Intra	MED4	Q9NPJ6	FAM13C	Homo sapiens	Q8NE31	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08303	MED4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MED4	VGNC	VGNC:63442
Rattus norvegicus	MED4	RGD	RGD:1306671
Bos taurus	MED4	VGNC	VGNC:31368
Canis familiaris	MED4	VGNC	VGNC:43139
Mus musculus	MED4	MGD	MGI:1914631
Macaca mulatta	MED4	VGNC	VGNC:74527
Others	MED4	NCBI

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