1. Gene
  2. MED4 - mediator complex subunit 4 Gene

MED4 - mediator complex subunit 4 Gene

Homo sapiens

Also known as ARC36; VDRIP; DRIP36; TRAP36; HSPC126

Gene ID: 29079 | Gene type: protein coding

About MED4

Cytogenetic location: 13q14.2 Genomic coordinates (GRCh38): 13:48,075,724-48,095,104 (from NCBI)

This gene has 4 transcripts (splice variants) and 221 orthologues. Ubiquitous expression in testis (RPKM 13.4), bone marrow (RPKM 12.6) and 25 other tissues.

Summary

This gene encodes a component of the Mediator complex. The Mediator complex interacts with DNA-binding gene-specific transcription factors to modulate transcription by RNA polymerase II. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

MED4 Products(2)

mRNA Protein Name
NM_001270629.2 NP_001257558.1 mediator of RNA polymerase II transcription subunit 4 isoform 2
NM_014166.4 NP_054885.1 mediator of RNA polymerase II transcription subunit 4 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
14638676 GOA
enables transcription coregulator activity IDA
IDA: Inferred from direct assay
10882111 GOA
Biological Process GO Annotation Evidence Reference Source
involved in transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10882111 GOA
Cellular Component GO Annotation Evidence Reference Source
part of core mediator complex IPI
IPI: Inferred from physical interaction
24882805 GOA
part of mediator complex IDA
IDA: Inferred from direct assay
10882111 GOA
located in nucleus IDA
IDA: Inferred from direct assay
10235267 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MED4 Protein Structure

Med4

Med4: Vitamin-D-receptor interacting Mediator subunit 4 (64 - 199)

  • 0
  • 100
  • 200
  • 270 a.a.
Protein Preferred Names Protein Names

mediator of RNA polymerase II transcription subunit 4

activator-recruited cofactor 36 kDa component

MED4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra MED4 Q9NPJ6 CCHCR1 Homo sapiens Q8TD31-3
Validated Y2H
25416956
Intra MED4 Q9NPJ6 FTCD Homo sapiens O95954
Validated Y2H
25416956
Intra MED4 Q9NPJ6 FTCD Homo sapiens O95954
Y2H Prey Pooling
25416956
Intra MED4 Q9NPJ6 CCDC146 Homo sapiens Q8IYE0-2
Y2H Array
25416956
Intra MED4 Q9NPJ6 MAB21L3 Homo sapiens Q8N8X9
Y2H Array
25416956
Intra MED4 Q9NPJ6 MAB21L3 Homo sapiens Q8N8X9
Y2H Prey Pooling
25416956
Intra MED4 Q9NPJ6 SSX3 Homo sapiens Q99909
Validated Y2H
25416956
Intra MED4 Q9NPJ6 TNFAIP8 Homo sapiens O95379
Y2H Array
25416956
Intra MED4 Q9NPJ6 KIFC3 Homo sapiens Q9BVG8
Validated Y2H
25416956
Intra MED4 Q9NPJ6 HAUS1 Homo sapiens Q96CS2
Validated Y2H
25416956
Intra MED4 Q9NPJ6 HAUS1 Homo sapiens Q96CS2
Y2H Array
25416956
Intra MED4 Q9NPJ6 HAUS1 Homo sapiens Q96CS2
BioID
25281560
Intra MED4 Q9NPJ6 SMARCD1 Homo sapiens Q96GM5
Validated Y2H
25416956
Intra MED4 Q9NPJ6 SMARCD1 Homo sapiens Q96GM5
Y2H Array
25416956
Intra MED4 Q9NPJ6 TXLNA Homo sapiens P40222
Validated Y2H
25416956
Intra MED4 Q9NPJ6 TXLNA Homo sapiens P40222
Y2H Prey Pooling
25416956
Intra MED4 Q9NPJ6 TXLNA Homo sapiens P40222
BioID
25281560
Intra MED4 Q9NPJ6 TXLNA Homo sapiens P40222
Pull Down
25281560
Intra MED4 Q9NPJ6 AMOT Homo sapiens Q4VCS5-2
Y2H Prey Pooling
25416956
Intra MED4 Q9NPJ6 AMOT Homo sapiens Q4VCS5-2
Y2H Array
25416956
Intra MED4 Q9NPJ6 MED12 Homo sapiens Q93074
BioID
25281560
Intra MED4 Q9NPJ6 MED12 Homo sapiens Q93074
Pull Down
25281560
Intra MED4 Q9NPJ6 MED12 Homo sapiens Q93074
Anti Tag CoIP
35271311
Intra MED4 Q9NPJ6 MED12 Homo sapiens Q93074
Anti Tag CoIP
33961781
Intra MED4 Q9NPJ6 MED12 Homo sapiens Q93074
Anti Bait CoIP
21293490
Intra MED4 Q9NPJ6 MED26 Homo sapiens O95402
Anti Tag CoIP
35271311
Intra MED4 Q9NPJ6 MED26 Homo sapiens O95402
Anti Tag CoIP
33961781
Intra MED4 Q9NPJ6 MED26 Homo sapiens O95402
Anti Tag CoIP
24882805
Intra MED4 Q9NPJ6 MED26 Homo sapiens O95402
BioID
25281560
Intra MED4 Q9NPJ6 MED26 Homo sapiens O95402
Pull Down
25281560
Intra MED4 Q9NPJ6 MED9 Homo sapiens Q9NWA0
Anti Tag CoIP
33961781
Intra MED4 Q9NPJ6 MED9 Homo sapiens Q9NWA0
Pull Down
14638676
Intra MED4 Q9NPJ6 MED9 Homo sapiens Q9NWA0
BioID
25281560
Intra MED4 Q9NPJ6 MED9 Homo sapiens Q9NWA0
Anti Tag CoIP
14638676
Intra MED4 Q9NPJ6 MED9 Homo sapiens Q9NWA0
Anti Tag CoIP
35271311
Intra MED4 Q9NPJ6 MED9 Homo sapiens Q9NWA0
Pull Down
25281560
Intra MED4 Q9NPJ6 MED21 Homo sapiens Q13503
Pull Down
25281560
Intra MED4 Q9NPJ6 MED21 Homo sapiens Q13503
Anti Tag CoIP
33961781
Intra MED4 Q9NPJ6 MED21 Homo sapiens Q13503
BioID
25281560
Intra MED4 Q9NPJ6 MED21 Homo sapiens Q13503
Anti Tag CoIP
35271311
Intra MED4 Q9NPJ6 NDC80 Homo sapiens O14777
Y2H Array
25416956
Intra MED4 Q9NPJ6 NDC80 Homo sapiens O14777
BioID
25281560
Intra MED4 Q9NPJ6 NDC80 Homo sapiens O14777
Y2H Prey Pooling
25416956
Intra MED4 Q9NPJ6 TLE5 Homo sapiens Q08117
Y2H Prey Pooling
25416956
Intra MED4 Q9NPJ6 TLE5 Homo sapiens Q08117
Validated Y2H
25416956
Intra MED4 Q9NPJ6 TLE5 Homo sapiens Q08117
Y2H Array
25416956
Intra MED4 Q9NPJ6 USHBP1 Homo sapiens Q8N6Y0
Validated Y2H
25416956
Intra MED4 Q9NPJ6 IFT20 Homo sapiens Q8IY31
Y2H Prey Pooling
25416956
Intra MED4 Q9NPJ6 IFT20 Homo sapiens Q8IY31
Validated Y2H
25416956
Intra MED4 Q9NPJ6 IFT20 Homo sapiens Q8IY31
Y2H Array
25416956
Intra MED4 Q9NPJ6 IFT20 Homo sapiens Q8IY31
Pull Down
25281560
Intra MED4 Q9NPJ6 C1orf216 Homo sapiens Q8TAB5
Validated Y2H
25416956
Intra MED4 Q9NPJ6 C1orf216 Homo sapiens Q8TAB5
Y2H Prey Pooling
25416956
Intra MED4 Q9NPJ6 FAM13C Homo sapiens Q8NE31
Y2H Prey Pooling
25416956
Intra MED4 Q9NPJ6 FAM13C Homo sapiens Q8NE31
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Orthologs Information

Species Symbol Source ID
Felis catus MED4 VGNC VGNC:63442
Rattus norvegicus MED4 RGD RGD:1306671
Bos taurus MED4 VGNC VGNC:31368
Canis familiaris MED4 VGNC VGNC:43139
Mus musculus MED4 MGD MGI:1914631
Macaca mulatta MED4 VGNC VGNC:74527
Others MED4 NCBI