Cxcr2 - chemokine (C-X-C motif) receptor 2 Gene

Mus musculus

Also known as CD128; IL8RA; Il8rb; CDw128; Cmkar2; Gpcr16; IL-8Rh; IL-8rb; mIL-8RH

Gene ID: 12765 | Gene type: protein coding

About Cxcr2

Chromosome 1: 74,193,148-74,200,405 forward strand.GRCm39:CM000994.3

This gene has 2 transcripts (splice variants), 244 orthologues, 25 paralogues and is associated with 127 phenotypes. Biased expression in placenta adult (RPKM 4.1), spleen adult (RPKM 3.8) and 8 other tissues.

Summary

Enables Chemokine Receptor activity. Acts upstream of or within negative regulation of apoptotic process. Predicted to be located in several cellular components, including cell surface; mast cell granule; and mitotic spindle. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; epithelium; and heart. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; acute pyelonephritis; end stage renal disease; and urinary bladder Cancer. Orthologous to human CXCR2 (C-X-C motif Chemokine Receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Cxcr2 Products(1)

mRNA	Protein	Name
NM_009909.3	NP_034039.1	C-X-C chemokine receptor type 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables chemokine receptor activity	IDA IDA: Inferred from direct assay	16618742	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	14764687	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16618742	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cxcr2 Protein Structure

7tmA_CXCR1_2

0
100
200
300
359 a.a.

Protein Preferred Names

Protein Names

C-X-C chemokine receptor type 2

CXC-R2	CXCR-2
GRO/MGSA receptor	IL-8 receptor alpha chain
IL-8R B	chemokine (C-X-C) receptor 2
high affinity interleukin-8 receptor B	interleukin 8 receptor, beta
interleukin-8 receptor type B

Related Agents

Clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15251	Reparixin	Inhibitor	99.95%	Phase 3
HY-15252	Reparixin L-lysine salt	Inhibitor	99.66%	Phase 3
HY-19519A	Ladarixin sodium	Antagonist	99.84%	Phase 3
HY-10198	Navarixin	Antagonist	98.90%	Phase 2
HY-13848	AZD8797		99.54%	Phase 2
HY-19855	AZD-5069	Antagonist	99.91%	Phase 2
HY-119339	SX-682	Inhibitor	99.67%	Phase 2
HY-50688	SB-265610	Antagonist	≥99.0%	Phase 2
HY-19768	Danirixin	Antagonist	98.88%	Phase 2
HY-18263C	Elubrixin tosylate	Antagonist	99.78%	Phase 2
HY-18263A	Elubrixin	Antagonist	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (18)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16711	SB225002	Antagonist	99.87%	Unkown
HY-101407	Nicotinamide N-oxide	Antagonist	99.85%	Unkown
HY-147392	CXCR2 antagonist 8	Antagonist	99.24%	Unkown
HY-101022	CXCR2-IN-1	Inhibitor	99.47%	Unkown
HY-120878	CXCR2-IN-2	Antagonist	99.52%	Unkown
HY-12927	SX-517	Antagonist	99.88%	Unkown
HY-10011	SCH 563705	Antagonist	99.86%	Unkown
HY-13021	SRT3190	Antagonist	99.77%	Unkown
HY-119259	AZD8309	Antagonist	99.98%	Unkown
HY-15462	SRT3109	Antagonist	99.82%	Unkown
HY-P4846	Ac-Pro-Gly-Pro-OH	Agonist	/	Unkown
HY-144784	CXCR2 antagonist 7	Antagonist	/	Unkown
HY-101407R	Nicotinamide N-oxide (Standard)	Antagonist	/	Unkown
HY-124056	AZ10397767	Antagonist	/	Unkown
HY-N2573	Corydalmine	Inhibitor	/	Unkown
HY-144780	CXCR2 antagonist 4	Antagonist	/	Unkown
HY-144781	CXCR2 antagonist 5	Antagonist	/	Unkown
HY-144783	CXCR2 antagonist 6	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cxcr2	NCBI	NCBI:3579

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