2. GPCR/G Protein Immunology/Inflammation
  3. CXCR
  4. Danirixin

Danirixin  (Synonyms: GSK1325756)

Cat. No.: HY-19768 Purity: 98.88%
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Danirixin is a selective, and reversible CXCR2 antagonist, with IC50?of?12.5 nM for CXCL8.

For research use only. We do not sell to patients.

Danirixin Chemical Structure

Danirixin Chemical Structure

CAS No. : 954126-98-8

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1 mg USD 70 In-stock
5 mg USD 140 In-stock
10 mg USD 230 In-stock
50 mg USD 680 In-stock
100 mg USD 980 In-stock
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This product is a controlled substance and not for sale in your territory.

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Based on 6 publication(s) in Google Scholar

Danirixin Related Antibodies

Top Publications Citing Use of Products

View All CXCR Isoform Specific Products:

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CXCR CXCR1 CXCR2 CXCR3 CXCR4 CXCR7 CXCR6

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Description

Danirixin is a selective, and reversible CXCR2 antagonist, with IC50?of?12.5 nM for CXCL8.

IC50 & Target[1]

CXCL8-CXCR2

12.5 nM (IC50)

In Vitro

Danirixin is a small molecule, CXCR2 antagonist being evaluated as a potential anti-inflammatory medicine[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Danirixin Related Antibodies
Clinical Trial
Molecular Weight

441.90

Formula

C19H21ClFN3O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=CC=C(Cl)C(S([C@H]2CCCNC2)(=O)=O)=C1O)NC3=C(C)C(F)=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 8 mg/mL (18.10 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2630 mL 11.3148 mL 22.6296 mL
5 mM 0.4526 mL 2.2630 mL 4.5259 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2630 mL 11.3148 mL 22.6296 mL 56.5739 mL
5 mM 0.4526 mL 2.2630 mL 4.5259 mL 11.3148 mL
10 mM 0.2263 mL 1.1315 mL 2.2630 mL 5.6574 mL
15 mM 0.1509 mL 0.7543 mL 1.5086 mL 3.7716 mL
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Danirixin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Danirixin954126-98-8GSK1325756GSK 1325756GSK-1325756CXCRCXC chemokine receptorsC-X-C motif chemokine receptorsInhibitorinhibitorinhibit

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