ARL8A - ADP ribosylation factor like GTPase 8A Gene

Homo sapiens

Also known as GIE2; ARL10B

Gene ID: 127829 | Gene type: protein coding

About ARL8A

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:202,133,404-202,144,737 (from NCBI)

This gene has 4 transcripts (splice variants), 206 orthologues and 30 paralogues. Ubiquitous expression in brain (RPKM 56.4), bone marrow (RPKM 24.8) and 25 other tissues.

Summary

Enables GTP binding activity. Predicted to be involved in chromosome segregation. Located in cytoplasm; midbody; and spindle midzone. [provided by Alliance of Genome Resources, Apr 2022]

ARL8A Products(2)

mRNA	Protein	Name
NM_001256129.2	NP_001243058.1	ADP-ribosylation factor-like protein 8A isoform 2
NM_138795.4	NP_620150.1	ADP-ribosylation factor-like protein 8A isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTP binding	IDA IDA: Inferred from direct assay	15331635	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24955142	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15331635	GOA
located in midbody	IDA IDA: Inferred from direct assay	15331635	GOA
located in spindle midzone	IDA IDA: Inferred from direct assay	15331635	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARL8A Protein Structure

Arf

0
100
186 a.a.

Protein Preferred Names

Protein Names

ADP-ribosylation factor-like protein 8A

ADP-ribosylation factor-like 10B

ARL8A Protein-protein interaction Information

Type Intra Cross	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ARL8A	Q96BM9	PUF60	Homo sapiens	Q9UHX1	Y2H Array	25416956
Intra	ARL8A	Q96BM9	PUF60	Homo sapiens	Q9UHX1	Validated Y2H	25416956
Intra	ARL8A	Q96BM9	MOCOS	Homo sapiens	Q96EN8	Anti Tag CoIP	33961781
Intra	ARL8A	Q96BM9	MOCOS	Homo sapiens	Q96EN8	Validated Y2H	32296183
Intra	ARL8A	Q96BM9	UQCRH	Homo sapiens	P07919	Y2H Prey Pooling	25416956
Intra	ARL8A	Q96BM9	PLEKHM1	Homo sapiens	Q9Y4G2	Anti Tag CoIP	28325809
Intra	ARL8A	Q96BM9	SPG21	Homo sapiens	Q9NZD8	Anti Tag CoIP	33961781
Intra	ARL8A	Q96BM9	SPG21	Homo sapiens	Q9NZD8	Validated Y2H	32296183
Cross	ARL8A	Q96BM9	Q86500-PRO_0000041224	Rubella virus	Q86500-PRO_0000041224	Protein Array	24955142
Cross	ARL8A	Q96BM9	Q86500-PRO_0000041224	Rubella virus	Q86500-PRO_0000041224	Pull Down	24955142

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Non-Proliferative Fibrocystic Change Of The Breast

Non-Proliferative Fibrocystic Change

Breast Fibrocystic Change, Non-Proliferative Type

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect Pre-designed Sets	Purity	Rare Diseases Unkown
HY-RS00998	ARL8A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ARL8A	RGD	RGD:1565940
Felis catus	ARL8A	VGNC	VGNC:59929
Macaca mulatta	ARL8A	VGNC	VGNC:69900
Bos taurus	ARL8A	VGNC	VGNC:26153
Mus musculus	ARL8A	MGD	MGI:1915974

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