WFDC12 - WAP four-disulfide core domain 12 Gene

Homo sapiens

Also known as WAP2; SWAM2; C20orf122; dJ211D12.4

Gene ID: 128488 | Gene type: protein coding

About WFDC12

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:45,123,425-45,124,465 (from NCBI)

This gene has 1 transcript (splice variant), 66 orthologues and 9 paralogues. Biased expression in skin (RPKM 13.5) and esophagus (RPKM 0.8).

Summary

This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. [provided by RefSeq, Jul 2008]

WFDC12 Products(1)

mRNA	Protein	Name
NM_080869.2	NP_543145.1	WAP four-disulfide core domain protein 12 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WFDC12 Protein Structure

WAP

0
100
111 a.a.

Protein Preferred Names

Protein Names

WAP four-disulfide core domain protein 12

protease inhibitor WAP2

WFDC12 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	WFDC12	Q8WWY7	SLC39A7	Homo sapiens	Q92504	Validated Y2H	32296183
Intra	WFDC12	Q8WWY7	SGTA	Homo sapiens	O43765	Y2H Array	32296183
Intra	WFDC12	Q8WWY7	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	32296183
Intra	WFDC12	Q8WWY7	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32296183
Intra	WFDC12	Q8WWY7	SGTB	Homo sapiens	Q96EQ0	Validated Y2H	32296183
Intra	WFDC12	Q8WWY7	SGTB	Homo sapiens	Q96EQ0	Y2H Array	32296183
Intra	WFDC12	Q8WWY7	SGTB	Homo sapiens	Q96EQ0	Y2H Prey Pooling	32296183
Intra	WFDC12	Q8WWY7	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	WFDC12	Q8WWY7	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	WFDC12	Q8WWY7	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Autosomal Recessive Congenital Ichthyosis

Lamellar Ichthyosis	Congenital Ichthyosiform Erythroderma
Li	Congenital Nonbullous Ichthyosiform Erythroderma
Arci	Congenital Lamellar Ichthyosis
Nonbullous Congenital Ichthyosiform Erythroderma	Cie
Congenital Non-Bullous Ichthyosiform Erythroderma	Erythrodermic Ichthyosis
Nbcie	Ncie
Non-Bullous Congenital Ichthyosiform Erythroderma	Collodion Baby
Ichthyosis, Lamellar	Non Bullous Congenital Ichthyosiform Erythroderma
Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form	Ichthyosiform Erythroderma, Congenital, Nonbullous, 1
Collodion Baby Syndrome	Ichthyoses, Lamellar
Nbie	Nonbullous Ichthyosiform Erythroderma
Classic Lamellar Ichthyosis	Ichthyosiform Erythroderma Nonbullous Congenital
Ichthyosiform Erythroderma Congenital	Ichthyosis, Congenital, Autosomal Recessive
Ichthyosiform Erythroderma, Congenital	Collodion Fetus
Non-Bullous Ichthyosiform Erythroderma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15810	WFDC12 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	WFDC12	MGD	MGI:2183434
Macaca mulatta	WFDC12	VGNC	VGNC:79009
Rattus norvegicus	WFDC12	RGD	RGD:1303229

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