2. Gene
  3. SLC39A7 - solute carrier family 39 member 7 Gene

SLC39A7 - solute carrier family 39 member 7 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as KE4; AGM9; HKE4; ZIP7; RING5; H2-KE4; D6S115E; D6S2244E

Gene ID: 7922 | Gene type: protein coding

About SLC39A7

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:33,200,867-33,204,437 (from NCBI)

This gene has 17 transcripts (splice variants), 1 gene allele, 175 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in prostate (RPKM 58.8), placenta (RPKM 52.4) and 25 other tissues.

Summary

The protein encoded by this gene transports zinc from the Golgi and endoplasmic reticulum to the cytoplasm. This transport may be important for activation of tyrosine kinases, some of which could be involved in Cancer progression. Therefore, modulation of the encoded protein could be useful as a therapeutic agent against Cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

SLC39A7 Products(3)

mRNA Protein Name
NM_001077516.2 NP_001070984.1 zinc transporter SLC39A7 isoform 1 precursor
NM_001288777.2 NP_001275706.1 zinc transporter SLC39A7 isoform 2
NM_006979.3 NP_008910.2 zinc transporter SLC39A7 isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
22317921 GOA
enables zinc ion transmembrane transporter activity IDA
IDA: Inferred from direct assay
14525538 GOA
enables zinc ion transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
30718914 GOA
Biological Process GO Annotation Evidence Reference Source
involved in B cell differentiation IMP
IMP: Inferred from mutant phenotype
30718914 GOA
involved in intracellular zinc ion homeostasis IMP
IMP: Inferred from mutant phenotype
29980658 GOA
involved in regulation of ferroptosis IMP
IMP: Inferred from mutant phenotype
33608508 GOA
involved in zinc ion transmembrane transport IDA
IDA: Inferred from direct assay
14525538 GOA
Cellular Component GO Annotation Evidence Reference Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
14525538 GOA
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
29980658 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC39A7 Protein Structure

Zip

Zip: ZIP Zinc transporter (133 - 466)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 469 a.a.
Protein Preferred Names Protein Names

zinc transporter SLC39A7

HLA class II region expressed gene KE4

SLC39A7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SLC39A7 Q92504 LCE4A Homo sapiens Q5TA78
Y2H Prey Pooling
32296183
Intra
SLC39A7 Q92504 LCE4A Homo sapiens Q5TA78
Y2H Array
32296183
Intra
SLC39A7 Q92504 LCE2D Homo sapiens Q5TA82
Y2H Array
32296183
Intra
SLC39A7 Q92504 LCE2D Homo sapiens Q5TA82
Y2H Prey Pooling
32296183
Intra
SLC39A7 Q92504 KRTAP9-2 Homo sapiens Q9BYQ4
Y2H Prey Pooling
32296183
Intra
SLC39A7 Q92504 KRTAP9-2 Homo sapiens Q9BYQ4
Validated Y2H
32296183
Intra
SLC39A7 Q92504 KRTAP9-2 Homo sapiens Q9BYQ4
Y2H Array
32296183
Intra
SLC39A7 Q92504 TNFRSF10D Homo sapiens Q9UBN6
Validated Y2H
32296183
Intra
SLC39A7 Q92504 TNFRSF10D Homo sapiens Q9UBN6
Y2H Array
32296183
Intra
SLC39A7 Q92504 TNFRSF10D Homo sapiens Q9UBN6
Y2H Prey Pooling
32296183
Intra
SLC39A7 Q92504 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
Intra
SLC39A7 Q92504 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
Intra
SLC39A7 Q92504 LCE5A Homo sapiens Q5TCM9
Y2H Prey Pooling
32296183
Intra
SLC39A7 Q92504 LCE5A Homo sapiens Q5TCM9
Y2H Array
32296183
Intra
SLC39A7 Q92504 LCE1F Homo sapiens Q5T754
Y2H Prey Pooling
32296183
Intra
SLC39A7 Q92504 LCE1F Homo sapiens Q5T754
Y2H Array
32296183
Intra
SLC39A7 Q92504 WFDC12 Homo sapiens Q8WWY7
Y2H Prey Pooling
32296183
Intra
SLC39A7 Q92504 WFDC12 Homo sapiens Q8WWY7
Y2H Array
32296183
Intra
SLC39A7 Q92504 LCE1A Homo sapiens Q5T7P2
Y2H Prey Pooling
32296183
Intra
SLC39A7 Q92504 LCE2C Homo sapiens Q5TA81
Y2H Prey Pooling
32296183
Intra
SLC39A7 Q92504 LCE2C Homo sapiens Q5TA81
Y2H Array
32296183
Intra
SLC39A7 Q92504 KRTAP5-7 Homo sapiens Q6L8G8
Y2H Array
32296183
Intra
SLC39A7 Q92504 KRTAP5-7 Homo sapiens Q6L8G8
Y2H Prey Pooling
32296183
Intra
SLC39A7 Q92504 RSPO2 Homo sapiens Q6UXX9-2
Y2H Prey Pooling
32296183
Intra
SLC39A7 Q92504 RSPO2 Homo sapiens Q6UXX9-2
Y2H Array
32296183
Intra
SLC39A7 Q92504 LCE1C Homo sapiens Q5T751
Y2H Prey Pooling
32296183
Intra
SLC39A7 Q92504 LCE1C Homo sapiens Q5T751
Y2H Array
32296183
Intra
SLC39A7 Q92504 SPRY3 Homo sapiens O43610
Y2H Prey Pooling
32296183
Intra
SLC39A7 Q92504 SPRY3 Homo sapiens O43610
Y2H Array
32296183
Intra
SLC39A7 Q92504 SLC34A2 Homo sapiens O95436-2
Y2H Prey Pooling
32296183
Intra
SLC39A7 Q92504 SLC34A2 Homo sapiens O95436-2
Y2H Array
32296183
Intra
SLC39A7 Q92504 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
SLC39A7 Q92504 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
SLC39A7 Q92504 UNC93A Homo sapiens Q86WB7-2
Y2H Array
32296183
Intra
SLC39A7 Q92504 UNC93A Homo sapiens Q86WB7-2
Y2H Prey Pooling
32296183
Intra
SLC39A7 Q92504 GJA8 Homo sapiens P48165
Y2H Prey Pooling
32296183
Intra
SLC39A7 Q92504 GJA8 Homo sapiens P48165
Y2H Array
32296183
Intra
SLC39A7 Q92504 SHISAL1 Homo sapiens Q3SXP7
Y2H Prey Pooling
32296183
Intra
SLC39A7 Q92504 SHISAL1 Homo sapiens Q3SXP7
Y2H Array
32296183
Intra
SLC39A7 Q92504 LELP1 Homo sapiens Q5T871
Y2H Prey Pooling
32296183
Intra
SLC39A7 Q92504 LELP1 Homo sapiens Q5T871
Y2H Array
32296183
Intra
SLC39A7 Q92504 CSNK2A1 Homo sapiens P68400
IF
22317921
Intra
SLC39A7 Q92504 CSNK2A1 Homo sapiens P68400
Anti Bait CoIP
22317921
Intra
SLC39A7 Q92504 RGS17 Homo sapiens Q9UGC6
Validated Y2H
32296183
Intra
SLC39A7 Q92504 RGS17 Homo sapiens Q9UGC6
Y2H Prey Pooling
32296183
Intra
SLC39A7 Q92504 RGS17 Homo sapiens Q9UGC6
Y2H Array
32296183
Intra
SLC39A7 Q92504 KCNF1 Homo sapiens Q9H3M0
Y2H Prey Pooling
32296183
Intra
SLC39A7 Q92504 KCNF1 Homo sapiens Q9H3M0
Validated Y2H
32296183
Intra
SLC39A7 Q92504 KCNF1 Homo sapiens Q9H3M0
Y2H Array
32296183
Intra
SLC39A7 Q92504 BIK Homo sapiens Q13323
Y2H Prey Pooling
32296183
Intra
SLC39A7 Q92504 BIK Homo sapiens Q13323
Y2H Array
32296183
Intra
SLC39A7 Q92504 CRCT1 Homo sapiens Q9UGL9
Validated Y2H
32296183
Intra
SLC39A7 Q92504 CRCT1 Homo sapiens Q9UGL9
Y2H Array
32296183
Intra
SLC39A7 Q92504 CRCT1 Homo sapiens Q9UGL9
Y2H Prey Pooling
32296183
Intra
SLC39A7 Q92504 SMCP Homo sapiens P49901
Y2H Prey Pooling
32296183
Intra
SLC39A7 Q92504 SMCP Homo sapiens P49901
Y2H Array
32296183
Intra
SLC39A7 Q92504 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra
SLC39A7 Q92504 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Intra
SLC39A7 Q92504 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Agammaglobulinemia 9, Autosomal Recessive

AGM9

Agammaglobulinemia, Autosomal Recessive, Due To Slc39a7 Defect
Agammaglobulinemia 9
Acrodermatitis Enteropathica, Zinc-Deficiency Type

Acrodermatitis Enteropathica

AEZ

Enteropathica

Brandt Syndrome

Ae

Acrodermatitis Enteropathica Zinc Deficiency Type

Danbolt-Cross Syndrome

Acrodermatitis Enteropathica, Zinc Deficiency Type

Inherited Zinc Deficiency

Acrodermatitis Enteropathica, Zinc Deficiency

Danbolt-Closs Syndrome

Primary Zinc Malabsorption Syndrome
Ehlers-Danlos Syndrome, Spondylodysplastic Type, 3

Spondylocheirodysplasia, Ehlers-Danlos Syndrome-Like

Scd-Eds

EDSSPD3

Ehlers-Danlos Syndrome Spondylodysplastic Type 3

Ehlers-Danlos Syndrome, Spondylocheirodysplastic Type

Slc39a13-Related Spondylodysplastic Ehlers-Danlos Syndrome

Slc39a13-Related Speds

Slc39a13-Related Spondylodysplastic Eds

Spondylocheirodysplastic Ehlers-Danlos Syndrome

Speds-Slc39a13

Ehlers-Danlos Syndrome-Like Spondylocheirodysplasia

Ehlers-Danlos Syndrome, Spondylodysplastic, Type 3
Enophthalmos
Ehlers-Danlos Syndrome

Eds

Cutis Hyperelastica

Elastic Skin

Ehlers-Danlos Syndromes

Ed Syndrome

Ehlers Danlos Syndrome

Ehlers Danlos Disease

Eds - [Ehlers-Danlos Syndrome]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-114395 NVS-ZP7-4 Inhibitor 98.85% Unkown
HY-114395A (R)-NVS-ZP7-4 98.80% Unkown
HY-RS13238 SLC39A7 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SLC39A7 VGNC VGNC:46406
Mus musculus SLC39A7 MGD MGI:95909
Macaca mulatta SLC39A7 VGNC VGNC:77592
Rattus norvegicus SLC39A7 RGD RGD:1593280
Bos taurus SLC39A7 VGNC VGNC:34867