Bcar1 - breast cancer anti-estrogen resistance 1 Gene

Mus musculus

Also known as Cas; Crkas

Gene ID: 12927 | Gene type: protein coding

About Bcar1

Summary

Predicted to enable protein domain specific binding activity and protein kinase binding activity. Involved in G protein-coupled receptor signaling pathway and platelet-derived growth factor receptor signaling pathway. Acts upstream of or within cell migration. Located in several cellular components, including actin cytoskeleton; focal adhesion; and lamellipodium. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in breast ductal carcinoma. Orthologous to human BCAR1 (BCAR1 scaffold protein, Cas family member). [provided by Alliance of Genome Resources, Apr 2022]

Bcar1 Products(2)

mRNA	Protein	Name
NM_001198839.1	NP_001185768.1	breast cancer anti-estrogen resistance protein 1 isoform A
NM_009954.3	NP_034084.2	breast cancer anti-estrogen resistance protein 1 isoform B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	7479864	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	9083073	MGI
acts upstream of or within cell migration	IDA IDA: Inferred from direct assay	15728191	MGI
involved in platelet-derived growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	9083073	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in actin cytoskeleton	IDA IDA: Inferred from direct assay	11864995	MGI
located in focal adhesion	IDA IDA: Inferred from direct assay	15728191	MGI
located in lamellipodium	IDA IDA: Inferred from direct assay	15728191	MGI
located in membrane	IMP IMP: Inferred from mutant phenotype	22801373	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

breast cancer anti-estrogen resistance protein 1

CRK-associated substrate	p130 Cas
p130cas	v-crk-associated tyrosine kinase substrate

Bcar1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Bcar1	Q61140	Ptk2	Mus musculus	P34152	Anti Bait CoIP	18233957
Intra	Bcar1	Q61140	Nphp1	Mus musculus	Q9QY53	Y2H	10739664
Intra	Bcar1	Q61140	Srcin1	Mus musculus	Q9QWI6	Pull Down	14657239
Cross	Bcar1	Q61140	PTPN1	Homo sapiens	P18031	Phosphatase Assay	9418872
Cross	Bcar1	Q61140	PTPN1	Homo sapiens	P18031	Pull Down	12023880

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01397	BCAR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bcar1	NCBI	NCBI:9564

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