HNRNPL - heterogeneous nuclear ribonucleoprotein L Gene

Homo sapiens

Also known as HNRPL; hnRNP-L; P/OKcl.14

Gene ID: 3191 | Gene type: protein coding

About HNRNPL

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:38,836,370-38,852,347 (from NCBI)

This gene has 15 transcripts (splice variants), 1 gene allele, 295 orthologues and 5 paralogues. Ubiquitous expression in bone marrow (RPKM 99.2), lymph node (RPKM 60.1) and 25 other tissues.

Summary

Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with Other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

HNRNPL Products(3)

mRNA	Protein	Name
NM_001005335.2	NP_001005335.1	heterogeneous nuclear ribonucleoprotein L isoform b
NM_001385651.1	NP_001372580.1	heterogeneous nuclear ribonucleoprotein L isoform c
NM_001533.3	NP_001524.2	heterogeneous nuclear ribonucleoprotein L isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables pre-mRNA intronic binding	IDA IDA: Inferred from direct assay	25623890	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11809897	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	11809897	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	33174841	GOA
involved in regulation of alternative mRNA splicing, via spliceosome	IMP IMP: Inferred from mutant phenotype	25623890	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	33174841	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	33174841	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	2687284	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15798186	GOA
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	2687284	GOA
located in ribonucleoprotein granule	IDA IDA: Inferred from direct assay	17289661	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HNRNPL Protein Structure

RRM_5

0
100
200
300
400
500
589 a.a.

Protein Preferred Names

Protein Names

heterogeneous nuclear ribonucleoprotein L

epididymis secretory sperm binding protein

HNRNPL Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HNRNPL	P14866	HNRNPA2B1	Homo sapiens	P22626	Anti Tag CoIP	35271311
Intra	HNRNPL	P14866	HNRNPA2B1	Homo sapiens	P22626	Anti Bait CoIP	23976881
Intra	HNRNPL	P14866	VHL	Homo sapiens	P40337	Anti Bait CoIP	23976881
Intra	HNRNPL	P14866	HNRNPK	Homo sapiens	P61978	Anti Tag CoIP	35271311

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Alzheimer Disease 5

Ad5	Alzheimer'S Disease 5
Alzheimer Disease, Familial, 5	Alzheimer Disease-5
Alzheimer Disease, Familial 5	Alzheimer'S Disease 5, Late Onset
Alzheimer Disease, Familial, Type 5

Mouth Disease

Mouth Diseases

Mouth Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06274	HNRNPL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	HNRNPL	MGD	MGI:104816
Rattus norvegicus	HNRNPL	RGD	RGD:71059
Macaca mulatta	HNRNPL	VGNC	VGNC:81187
Bos taurus	HNRNPL	VGNC	VGNC:54437
Felis catus	HNRNPL	VGNC	VGNC:67610
Canis familiaris	HNRNPL	VGNC	VGNC:54847

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