CIB4 - calcium and integrin binding family member 4 Gene

Homo sapiens

Also known as KIP4

Gene ID: 130106 | Gene type: protein coding

About CIB4

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:26,581,205-26,641,366 (from NCBI)

This gene has 3 transcripts (splice variants), 112 orthologues and 8 paralogues. Low expression observed in reference dataset.

Summary

Enables calcium ion binding activity and magnesium ion binding activity. [provided by Alliance of Genome Resources, Apr 2022]

CIB4 Products(1)

mRNA	Protein	Name
NM_001029881.3	NP_001025052.1	calcium and integrin-binding family member 4

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	22779914	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	22779914	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22779914	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CIB4 Protein Structure

EF-hand_7

0
100
185 a.a.

Protein Preferred Names

Protein Names

calcium and integrin-binding family member 4

CIB4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CIB4	A0PJX0	CREB5	Homo sapiens	Q02930-3	Validated Y2H	32296183
Intra	CIB4	A0PJX0	VASN	Homo sapiens	Q6EMK4	Validated Y2H	32296183
Intra	CIB4	A0PJX0	ATG9A	Homo sapiens	Q7Z3C6-3	Validated Y2H	32296183
Intra	CIB4	A0PJX0	MYPOP	Homo sapiens	Q86VE0	Validated Y2H	32296183
Intra	CIB4	A0PJX0	TXN2	Homo sapiens	Q99757	Validated Y2H	32296183
Intra	CIB4	A0PJX0	ZBTB9	Homo sapiens	Q96C00	Validated Y2H	32296183
Intra	CIB4	A0PJX0	UBB	Homo sapiens	P0CG47	Anti Tag CoIP	28514442
Intra	CIB4	A0PJX0	UBB	Homo sapiens	P0CG47	Anti Tag CoIP	33961781
Intra	CIB4	A0PJX0	TACO1	Homo sapiens	Q9BSH4	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Usher Syndrome, Type Ij

Usher Syndrome Type 1j	USH1J
Usher Syndrome Type Ij	Usher Syndrome 1j
Usher'S Syndrome Type 1j

Gingival Hypertrophy

Hypertrophy Of Gingivae

Gingival Fibromatosis

Hereditary Gingival Fibromatosis	Hereditary Gingival Hyperplasia
Autosomal Dominant Gingival Fibromatosis	Autosomal Dominant Gingival Hyperplasia
Fibromatosis, Gingival, Hereditary	Fibromatosis, Gingival

Usher Syndrome, Type I

USH1	Usher Syndrome Type 1
Us1	Usher Syndrome, Type 1b
Usher Syndrome Type 1e	Retinitis Pigmentosa And Congenital Deafness
Usher Syndrome, Type Ie	USH1E
Usher Syndrome, Type 1e	Usher Syndrome, Type 1a
Usher Syndrome, Type Ib	Usher Syndrome Type 1b
Usher Syndrome Type Ie	Usher Syndrome Type I
Usher 1	Usher Syndrome, Type 1
Ush1a	Usher Syndrome, Type I, French Variety
Usher Syndrome, Type Ia	Usher Syndrome 1b
USH1B	Usher'S Syndrome Type 1b
Usher Syndrome Type Ib	Ushib

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02709	CIB4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CIB4	VGNC	VGNC:27362
Rattus norvegicus	CIB4	RGD	RGD:1584147
Mus musculus	CIB4	MGD	MGI:1920509
Macaca mulatta	CIB4	VGNC	VGNC:71379
Canis familiaris	CIB4	VGNC	VGNC:39269
Felis catus	CIB4	VGNC	VGNC:60899

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