MYPOP - Myb related transcription factor, partner of profilin Gene

Homo sapiens

Also known as P42pop

Gene ID: 339344 | Gene type: protein coding

About MYPOP

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:45,890,023-45,902,613 (from NCBI)

This gene has 1 transcript (splice variant) and 93 orthologues. Ubiquitous expression in brain (RPKM 2.5), spleen (RPKM 2.4) and 25 other tissues.

Summary

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

MYPOP Products(1)

mRNA	Protein	Name
NM_001012643.4	NP_001012661.1	myb-related transcription factor, partner of profilin

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYPOP Protein Structure

Myb_DNA-bind_5

0
100
200
300
399 a.a.

Protein Preferred Names

Protein Names

myb-related transcription factor, partner of profilin

myb-related protein p42POP

Related Diseases

Diseases

Alias

Myopathy, Centronuclear, 1

Autosomal Dominant Centronuclear Myopathy	CNM1
Centronuclear Myopathy 1	Ad-Cnm
Myopathy, Centronuclear, Autosomal Dominant	Myotubular Myopathy, Autosomal Dominant
Centronuclear Myopathy, Autosomal, Modifier Of	Autosomal Dominant Myotubular Myopathy
Dnm2-Related Centronuclear Myopathy	Centronuclear Myopathy Autosomal Dominant
Myopathies, Structural, Congenital	Myopathy, Centronuclear, Type 1

Neuronopathy, Distal Hereditary Motor, Type Iia

HMN2A	Hmn Iia
Neuropathy, Distal Hereditary Motor, Type Iia	Dhmn2a
Distal Hereditary Motor Neuronopathy Type 2a	Distal Hereditary Motor Neuropathy Type Iia
Neuronopathy, Distal Hereditary Motor, Type 2a	Spinal Muscular Atrophy, Distal, Adult, Autosomal Dominant, Iia
Charcot-Marie-Tooth Disease, Spinal, Iia	Autosomal Dominant Adult Spinal Muscular Atrophy Iia
Spinal Charcot-Marie-Tooth Disease Iia	Neuronopathy, Distal Hereditary Motor, 2a
Charcot-Marie-Tooth Disease Spinal Iia	Spinal Muscular Atrophy Distal Adult Autosomal Dominant Iia
Neuropathy, Motor, Distal, Hereditary, Type 2a

Nemaline Myopathy 11, Autosomal Recessive

NEM11

Nemaline Myopathy 11

Nemaline Myopathy 10

NEM10

Myopathy, Nemaline, Type 10

Carey-Fineman-Ziter Syndrome 1

Carey-Fineman-Ziter Syndrome	CFZS
Congenital Nonprogressive Myopathy With Moebius And Robin Sequences	Myopathy, Congenital Nonprogressive, With Moebius Sequence And Robin Sequence
Cfz Syndrome	Carey Fineman Ziter Syndrome
Myopathy, Congenital Nonprogressive With Moebius And Robin Sequences	Myopathy-Moebius-Robin Syndrome
CFZS1	Moebius Sequence, Robin Complex, And Hypotonia
Congenital Non-Progressive Myopathy With Moebius And Robin Sequences

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08968	MYPOP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MYPOP	MGD	MGI:2446472
Canis familiaris	MYPOP	VGNC	VGNC:43587
Bos taurus	MYPOP	VGNC	VGNC:58393
Rattus norvegicus	MYPOP	RGD	RGD:1565160

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