1. Gene
  2. VASN - vasorin Gene

VASN - vasorin Gene

Homo sapiens

Also known as SLITL2

Gene ID: 114990 | Gene type: protein coding

About VASN

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:4,371,848-4,383,538 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 255 orthologues and 22 paralogues. Broad expression in placenta (RPKM 16.9), kidney (RPKM 16.4) and 24 other tissues.

Summary

Enables transforming growth factor beta binding activity. Involved in negative regulation of epithelial to mesenchymal transition and negative regulation of transforming growth factor beta receptor signaling pathway. Located in cell surface and extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

VASN Products(1)

mRNA Protein Name
NM_138440.3 NP_612449.2 vasorin precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables transforming growth factor beta binding IPI
IPI: Inferred from physical interaction
15247411 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cell surface IDA
IDA: Inferred from direct assay
15247411 GOA
located in extracellular exosome IDA
IDA: Inferred from direct assay
21082674 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
15247411 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VASN Protein Structure

LRRNT

LRRNT: Leucine rich repeat N-terminal domain (23 - 51)

LRR_1

LRR_1: Leucine Rich Repeat (78 - 98)

LRR_8

LRR_8: Leucine rich repeat (101 - 160)

LRR_8

LRR_8: Leucine rich repeat (193 - 249)

  • 0
  • 200
  • 400
  • 600
  • 673 a.a.
Protein Preferred Names Protein Names

vasorin

protein slit-like 2

VASN Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
VASN Q6EMK4 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra
VASN Q6EMK4 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 KRTAP10-7 Homo sapiens P60409
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 KRTAP10-7 Homo sapiens P60409
Y2H Array
32296183
Intra
VASN Q6EMK4 KRTAP4-2 Homo sapiens Q9BYR5
Validated Y2H
32296183
Intra
VASN Q6EMK4 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 ADAMTSL4 Homo sapiens Q6UY14-3
Validated Y2H
32296183
Intra
VASN Q6EMK4 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Array
32296183
Intra
VASN Q6EMK4 KRTAP12-2 Homo sapiens P59991
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 KRTAP12-2 Homo sapiens P59991
Y2H Array
32296183
Intra
VASN Q6EMK4 RGS20 Homo sapiens O76081-6
Y2H Array
32296183
Intra
VASN Q6EMK4 RGS20 Homo sapiens O76081-6
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 RNF31 Homo sapiens Q96EP0-3
Validated Y2H
25416956
Intra
VASN Q6EMK4 RNF31 Homo sapiens Q96EP0-3
Y2H Array
25416956
Intra
VASN Q6EMK4 LCE2D Homo sapiens Q5TA82
Y2H Array
32296183
Intra
VASN Q6EMK4 LCE2D Homo sapiens Q5TA82
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 KRTAP4-11 Homo sapiens Q9BYQ6
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 KRTAP4-11 Homo sapiens Q9BYQ6
Validated Y2H
32296183
Intra
VASN Q6EMK4 KRTAP4-11 Homo sapiens Q9BYQ6
Y2H Array
32296183
Intra
VASN Q6EMK4 KRTAP9-3 Homo sapiens Q9BYQ3
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 KRTAP9-3 Homo sapiens Q9BYQ3
Validated Y2H
32296183
Intra
VASN Q6EMK4 KRTAP9-3 Homo sapiens Q9BYQ3
Y2H Array
32296183
Intra
VASN Q6EMK4 KRTAP11-1 Homo sapiens Q8IUC1
Validated Y2H
32296183
Intra
VASN Q6EMK4 KRTAP11-1 Homo sapiens Q8IUC1
Y2H Array
32296183
Intra
VASN Q6EMK4 KRTAP11-1 Homo sapiens Q8IUC1
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra
VASN Q6EMK4 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
Intra
VASN Q6EMK4 KRTAP12-3 Homo sapiens P60328
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 KRTAP12-3 Homo sapiens P60328
Y2H Array
32296183
Intra
VASN Q6EMK4 VWC2 Homo sapiens Q2TAL6
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 VWC2 Homo sapiens Q2TAL6
Y2H Array
32296183
Intra
VASN Q6EMK4 KRTAP9-8 Homo sapiens Q9BYQ0
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 KRTAP9-8 Homo sapiens Q9BYQ0
Validated Y2H
32296183
Intra
VASN Q6EMK4 KRTAP9-8 Homo sapiens Q9BYQ0
Y2H Array
32296183
Intra
VASN Q6EMK4 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra
VASN Q6EMK4 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 ZNF837 Homo sapiens Q96EG3
Validated Y2H
32296183
Intra
VASN Q6EMK4 LCE2C Homo sapiens Q5TA81
Y2H Array
32296183
Intra
VASN Q6EMK4 LCE2C Homo sapiens Q5TA81
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 GUCD1 Homo sapiens Q96NT3-2
Validated Y2H
32296183
Intra
VASN Q6EMK4 KRTAP17-1 Homo sapiens Q9BYP8
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 KRTAP17-1 Homo sapiens Q9BYP8
Validated Y2H
32296183
Intra
VASN Q6EMK4 KRTAP17-1 Homo sapiens Q9BYP8
Y2H Array
32296183
Intra
VASN Q6EMK4 KRTAP5-11 Homo sapiens Q6L8G4
Validated Y2H
32296183
Intra
VASN Q6EMK4 KRTAP10-6 Homo sapiens P60371
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 KRTAP10-6 Homo sapiens P60371
Y2H Array
32296183
Intra
VASN Q6EMK4 CELF5 Homo sapiens Q8N6W0
Validated Y2H
32296183
Intra
VASN Q6EMK4 LCE1C Homo sapiens Q5T751
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 LCE1C Homo sapiens Q5T751
Y2H Array
32296183
Intra
VASN Q6EMK4 CIB4 Homo sapiens A0PJX0
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 CIB4 Homo sapiens A0PJX0
Y2H Array
32296183
Intra
VASN Q6EMK4 NR4A3 Homo sapiens Q92570
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 NR4A3 Homo sapiens Q92570
Validated Y2H
32296183
Intra
VASN Q6EMK4 NR4A3 Homo sapiens Q92570
Y2H Array
32296183
Intra
VASN Q6EMK4 KRTAP2-4 Homo sapiens Q9BYR9
Validated Y2H
32296183
Intra
VASN Q6EMK4 KRTAP2-4 Homo sapiens Q9BYR9
Y2H Array
32296183
Intra
VASN Q6EMK4 KRTAP2-4 Homo sapiens Q9BYR9
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
VASN Q6EMK4 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
VASN Q6EMK4 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra
VASN Q6EMK4 KRTAP6-3 Homo sapiens Q3LI67
Y2H Array
32296183
Intra
VASN Q6EMK4 KRTAP6-3 Homo sapiens Q3LI67
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 TGM1 Homo sapiens P22735
Y2H Array
32296183
Intra
VASN Q6EMK4 TGM1 Homo sapiens P22735
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 AQP3 Homo sapiens Q92482
Validated Y2H
32296183
Intra
VASN Q6EMK4 KRTAP4-1 Homo sapiens Q9BYQ7
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 KRTAP4-1 Homo sapiens Q9BYQ7
Y2H Array
32296183
Intra
VASN Q6EMK4 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
VASN Q6EMK4 RGS17 Homo sapiens Q9UGC6
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 RGS17 Homo sapiens Q9UGC6
Validated Y2H
32296183
Intra
VASN Q6EMK4 RGS17 Homo sapiens Q9UGC6
Y2H Array
32296183
Intra
VASN Q6EMK4 KRTAP26-1 Homo sapiens Q6PEX3
Validated Y2H
32296183
Intra
VASN Q6EMK4 KRTAP26-1 Homo sapiens Q6PEX3
Y2H Array
32296183
Intra
VASN Q6EMK4 KRTAP26-1 Homo sapiens Q6PEX3
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 MDFI Homo sapiens Q99750
Validated Y2H
32296183
Intra
VASN Q6EMK4 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra
VASN Q6EMK4 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Intra
VASN Q6EMK4 ZNF417 Homo sapiens Q8TAU3
Validated Y2H
32296183
Intra
VASN Q6EMK4 HOXA1 Homo sapiens P49639
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 HOXA1 Homo sapiens P49639
Y2H Array
32296183
Intra
VASN Q6EMK4 TRIP6 Homo sapiens Q15654
Y2H Array
32296183
Intra
VASN Q6EMK4 TRIP6 Homo sapiens Q15654
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 SMCP Homo sapiens P49901
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 SMCP Homo sapiens P49901
Y2H Array
32296183
Intra
VASN Q6EMK4 KRTAP3-2 Homo sapiens Q9BYR7
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 KRTAP3-2 Homo sapiens Q9BYR7
Validated Y2H
32296183
Intra
VASN Q6EMK4 KRTAP3-2 Homo sapiens Q9BYR7
Y2H Array
32296183
Intra
VASN Q6EMK4 RGS19 Homo sapiens P49795
Y2H Array
32296183
Intra
VASN Q6EMK4 RGS19 Homo sapiens P49795
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra
VASN Q6EMK4 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 KRTAP3-1 Homo sapiens Q9BYR8
Validated Y2H
32296183
Intra
VASN Q6EMK4 KRTAP3-1 Homo sapiens Q9BYR8
Y2H Array
32296183
Intra
VASN Q6EMK4 KRTAP3-1 Homo sapiens Q9BYR8
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant VASN Proteins

Cat. No. Product Name Accession Purity
HY-P70999 Vasorin Protein, Human (552a.a, HEK293, His) Q6EMK4/AAH68575.1 (C24-P575) ≥95%

Related Diseases

Diseases Alias
Hematuria, Benign Familial

Benign Familial Hematuria

BFH

Thin Membrane Nephropathy

Tmn

Thin Basement Membrane Nephropathy

Thin-Basement-Membrane Nephropathy

Hematuria, Familial Benign

Hematuria Benign Familial

Hematuria, Benign, Familial

Thin Basement Membrane Disease

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus VASN MGD MGI:2177651
Canis familiaris VASN VGNC VGNC:54089
Rattus norvegicus VASN RGD RGD:1598149
Felis catus VASN VGNC VGNC:66921
Others VASN NCBI