CORT - cortistatin Gene

Homo sapiens

Also known as SST2; CST-14; CST-17; CST-29

Gene ID: 1325 | Gene type: protein coding

About CORT

Cytogenetic location: 1p36.22 Genomic coordinates (GRCh38): 1:10,450,031-10,451,998 (from NCBI)

This gene has 1 transcript (splice variant), 62 orthologues and 1 paralogue. Biased expression in brain (RPKM 6.6), testis (RPKM 2.0) and 1 other tissue.

Summary

This gene encodes a neuropeptide that is structurally similar to somatostatin. It binds to all known somatostatin receptors, and shares many pharmacological and functional properties with somatostatin, including the depression of neuronal activity. However, it also has many properties distinct from somatostatin, such as induction of slow-wave sleep, apparently by antagonism of the excitatory effects of acetylcholine on the cortex, reduction of locomotor activity, and activation of cation selective currents not responsive to somatostatin. The preproprotein undergoes further processing into multiple mature products. Read-through transcripts exist between this gene and the upstream APITD1 (apoptosis-inducing, TAF9-like domain 1) gene, as represented in GeneID:100526739. [provided by RefSeq, Nov 2010]

CORT Products(1)

mRNA	Protein	Name
NM_001302.5	NP_001293.3	cortistatin preproprotein

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled receptor binding	IPI IPI: Inferred from physical interaction	12915402	GOA
enables neuropeptide hormone activity	IDA IDA: Inferred from direct assay	9125122	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	9125122	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CORT Protein Structure

Somatostatin

0
105 a.a.

Protein Preferred Names

Protein Names

cortistatin

cortistatin-14

CORT Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CORT	O00230	MB	Homo sapiens	P02144	Anti Tag CoIP	33961781
Intra	CORT	O00230	MB	Homo sapiens	P02144	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Prolactinoma

Prolactin-Producing Pituitary Gland Adenoma	Prolactin-Secreting Pituitary Adenoma
Forbes-Albright Syndrome	Lactotroph Adenoma
Prl-Secreting Pituitary Adenoma	Prloma
Pituitary Lactotrophic Adenoma	Familial Prolactinoma
Pituitary Adenoma, Prolactin-Secreting	Prolactinoma Of Pituitary Gland
PSPA

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-117880	Exicorilant	Antagonist	99.48%	Phase 2

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-109042	Relacorilant	Antagonist	99.12%	Yes
HY-132811	Dazucorilant	Modulator	98.91%	Unkown
HY-15710	Cort108297	Antagonist	99.44%	Unkown
HY-117965	Miricorilant		/	Unkown
HY-RS03054	CORT Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CORT	RGD	RGD:2383
Mus musculus	CORT	MGD	MGI:109538
Macaca fascicularis	CORT	NCBI	NCBI:102138191
Others	CORT	NCBI

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