ZFP42 - ZFP42 zinc finger protein Gene

Homo sapiens

Also known as REX1; REX-1; ZNF754; zfp-42

Gene ID: 132625 | Gene type: protein coding

About ZFP42

Cytogenetic location: 4q35.2 Genomic coordinates (GRCh38): 4:187,995,771-188,005,246 (from NCBI)

This gene has 3 transcripts (splice variants), 75 orthologues and 2 paralogues. Biased expression in testis (RPKM 1.0), placenta (RPKM 0.5) and 1 other tissue.

Summary

Enables sequence-specific double-stranded DNA binding activity. Involved in female gonad development and male gonad development. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ZFP42 Products(2)

mRNA	Protein	Name
NM_001304358.2	NP_001291287.1	zinc finger protein 42 homolog
NM_174900.5	NP_777560.2	zinc finger protein 42 homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in female gonad development	IEP IEP: Inferred from expression pattern	18281244	GOA
involved in male gonad development	IEP IEP: Inferred from expression pattern	18281244	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16344273	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZFP42 Protein Structure

zf-C2H2_4

zf-H2C2_2

0
100
200
310 a.a.

Protein Preferred Names

Protein Names

zinc finger protein 42 homolog

REX1 transcription factor

ZFP42 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZFP42	Q96MM3	LHX2	Homo sapiens	P50458	Y2H Array	32296183
Intra	ZFP42	Q96MM3	LHX2	Homo sapiens	P50458	Y2H Prey Pooling	32296183
Intra	ZFP42	Q96MM3	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	ZFP42	Q96MM3	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	ZFP42	Q96MM3	RNF4	Homo sapiens	P78317	Y2H Array	32296183
Intra	ZFP42	Q96MM3	RNF4	Homo sapiens	P78317	Y2H Prey Pooling	32296183
Intra	ZFP42	Q96MM3	PIAS2	Homo sapiens	O75928-2	Y2H Prey Pooling	32296183
Intra	ZFP42	Q96MM3	PIAS2	Homo sapiens	O75928-2	Y2H Array	32296183
Intra	ZFP42	Q96MM3	SUMO1	Homo sapiens	P63165	Y2H Array	32296183
Intra	ZFP42	Q96MM3	SUMO1	Homo sapiens	P63165	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Inflammatory Bowel Disease 7

IBD7

Germ Cell And Embryonal Cancer

Germ Cell And Embryonal Neoplasm

Spermatocytoma

Spermatocytic Seminoma

Arthrogryposis, Distal, Type 1a

Distal Arthrogryposis Type 1	Digitotalar Dysmorphism
DA1A	Da1
Amcd1	Arthrogryposis, Distal, Type 2b4
Distal Arthrogryposis Type 1a	Arthrogryposis, Distal, Type 1
Arthrogryposis Multiplex Congenita Distal Type 1	Arthrogryposis Multiplex Congenita, Distal Type 1
Arthrogryposis Multiplex Congenita, Distal, Type I	Distal Arthrogryposis Type 1b
Arthrogryposis, Distal, 1a	Amc
Arthrogryposis Multiplex Congenita	Arthrogryposis, Distal, 2b4
DA2B4	Arthrogryposis Multiplex Congenita, Distal, Type 1
Arthrogryposis

Germ Cell Cancer

Malignant Germ Cell Tumor	Neoplasms, Germ Cell And Embryonal
Germ Cell Neoplasm	Germ Cell Tumour
Malignant Tumor Of The Germ Cell	Neoplasms Germ Cell
Malignant Germ Cell Neoplasm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16043	ZFP42 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ZFP42	MGD	MGI:99187
Macaca mulatta	ZFP42	VGNC	VGNC:107210
Rattus norvegicus	ZFP42	RGD	RGD:2319133
Canis familiaris	ZFP42	VGNC	VGNC:53510
Felis catus	ZFP42	VGNC	VGNC:107479
Bos taurus	ZFP42	VGNC	VGNC:37164

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