POC5 - POC5 centriolar protein Gene

Homo sapiens

Also known as C5orf37

Gene ID: 134359 | Gene type: protein coding

About POC5

Cytogenetic location: 5q13.3 Genomic coordinates (GRCh38): 5:75,674,124-75,717,437 (from NCBI)

This gene has 14 transcripts (splice variants) and 94 orthologues. Broad expression in testis (RPKM 10.4), lymph node (RPKM 4.7) and 24 other tissues.

Summary

Predicted to enable identical protein binding activity. Located in centrosome; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

POC5 Products(2)

mRNA	Protein	Name
NM_001099271.2	NP_001092741.1	centrosomal protein POC5 isoform 1
NM_152408.3	NP_689621.2	centrosomal protein POC5 isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centrosome	IDA IDA: Inferred from direct assay	21399614	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

centrosomal protein POC5

POC5 centriolar protein homolog

POC5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	POC5	Q8NA72	CETN2	Homo sapiens	P41208	Y2H Prey Pooling	25416956
Intra	POC5	Q8NA72	CETN2	Homo sapiens	P41208	Y2H Array	25416956
Intra	POC5	Q8NA72	CETN2	Homo sapiens	P41208	BioID	26638075
Intra	POC5	Q8NA72	CETN2	Homo sapiens	P41208	Anti Tag CoIP	33961781
Intra	POC5	Q8NA72	CETN2	Homo sapiens	P41208	Anti Bait CoIP	35709258
Intra	POC5	Q8NA72	CETN2	Homo sapiens	P41208	Validated Y2H	25416956
Intra	POC5	Q8NA72	CETN1	Homo sapiens	Q12798	Y2H Array	31515488
Intra	POC5	Q8NA72	TUBA4A	Homo sapiens	P68366	Anti Tag CoIP	30845169
Intra	POC5	Q8NA72	CETN3	Homo sapiens	O15182	Y2H Prey Pooling	25416956
Intra	POC5	Q8NA72	CETN3	Homo sapiens	O15182	BioID	26638075
Intra	POC5	Q8NA72	CETN3	Homo sapiens	O15182	Validated Y2H	25416956
Intra	POC5	Q8NA72	CETN3	Homo sapiens	O15182	Anti Bait CoIP	35709258
Intra	POC5	Q8NA72	CETN3	Homo sapiens	O15182	Y2H Array	25416956
Intra	POC5	Q8NA72	CETN3	Homo sapiens	O15182	Anti Tag CoIP	33961781
Intra	POC5	Q8NA72	FAM161A	Homo sapiens	Q3B820	BioID	26638075
Intra	POC5	Q8NA72	FAM161A	Homo sapiens	Q3B820	Y2H Prey Pooling	25416956
Intra	POC5	Q8NA72	FAM161A	Homo sapiens	Q3B820	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Syndromic Rod-Cone Dystrophy

Syndromic Retinitis Pigmentosa

Idiopathic Scoliosis

Scoliosis Idiopathic

Scoliosis

Orofaciodigital Syndrome I

OFD1	Orofaciodigital Syndrome 1
Oral-Facial-Digital Syndrome, Type I	Oral-Facial-Digital Syndrome 1
Ofds I	Papillon-Leage And Psaume Syndrome
Papillon-Leage-Psaume Syndrome	Oral-Facial-Digital Syndrome Type 1
Orofaciodigital Syndrome Type 1	Orofaciodigital Syndromes
Orofaciodigital Syndrome Type I	Oral-Facial-Digital Syndrome Type I
Ofd Syndrome 1	Ofds 1
Oral Facial Digital Syndrome 1	Oral Facial Digital Syndrome Type 1
Papillon-League-Psaume Syndrome	Ofdi
Ofdsi	Orofaciodigital Syndrome, Type I

Syringomyelia

Hydromyelia

Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly	Mcph
True Microcephaly	Microcephalia Vera
Microcephaly Vera	Microcephaly Primary Hereditary
Microcephaly, Primary, Autosomal Recessive	Primary Microcephaly

Bone Structure Disease

Primary Microcephaly

True Microcephaly

Microcephaly, Primary

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10806	POC5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	POC5	RGD	RGD:1310597
Bos taurus	POC5	VGNC	VGNC:33100
Mus musculus	POC5	MGD	MGI:1914713
Canis familiaris	POC5	VGNC	VGNC:44762
Felis catus	POC5	VGNC	VGNC:64272
Macaca mulatta	POC5	VGNC	VGNC:76119

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