2. Gene
  3. CETN3 - centrin 3 Gene

CETN3 - centrin 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CEN3; CDC31

Gene ID: 1070 | Gene type: protein coding

About CETN3

Cytogenetic location: 5q14.3 Genomic coordinates (GRCh38): 5:90,392,257-90,409,756 (from NCBI)

This gene has 6 transcripts (splice variants), 202 orthologues and 20 paralogues. Broad expression in testis (RPKM 62.8), adrenal (RPKM 10.5) and 21 other tissues.

Summary

The protein encoded by this gene contains four EF-hand calcium binding domains, and is a member of the centrin protein family. Centrins are evolutionarily conserved proteins similar to the CDC31 protein of S. cerevisiae. Yeast CDC31 is located at the centrosome of interphase and mitotic cells, where it plays a fundamental role in centrosome duplication and separation. Multiple forms of the proteins similar to the yeast centrin have been identified in human and Other mammalian cells, some of which have been shown to be associated with centrosome fractions. This protein appears to be one of the most abundant centrins associated with centrosome, which suggests a similar function to its yeast counterpart. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

CETN3 Products(3)

mRNA Protein Name
NM_001297765.2 NP_001284694.1 centrin-3 isoform 1
NM_001297768.2 NP_001284697.1 centrin-3 isoform 3
NM_004365.4 NP_004356.2 centrin-3 isoform 2
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
23591820 GOA
Cellular Component GO Annotation Evidence Reference Source
located in centriole IDA
IDA: Inferred from direct assay
23591820 GOA
located in centrosome IDA
IDA: Inferred from direct assay
21399614 GOA
part of nuclear pore nuclear basket IDA
IDA: Inferred from direct assay
23591820 GOA
part of transcription export complex 2 IDA
IDA: Inferred from direct assay
23591820 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CETN3 Protein Structure

EF-hand_7

EF-hand_7: EF-hand domain pair (30 - 88)

EF-hand_7

EF-hand_7: EF-hand domain pair (103 - 163)

  • 0
  • 100
  • 167 a.a.
Protein Preferred Names Protein Names

centrin-3

CDC31 yeast homolog

CETN3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra CETN3 O15182 SGSM1 Homo sapiens Q2NKQ1-4
Y2H Prey Pooling
32296183
Intra CETN3 O15182 SGSM1 Homo sapiens Q2NKQ1-4
Y2H Prey Pooling
25416956
Intra CETN3 O15182 SGSM1 Homo sapiens Q2NKQ1-4
Validated Y2H
32296183
Intra CETN3 O15182 SGSM1 Homo sapiens Q2NKQ1-4
Y2H Array
32296183
Intra CETN3 O15182 SGK1 Homo sapiens O00141
Y2H Prey Pooling
32296183
Intra CETN3 O15182 SGK1 Homo sapiens O00141
Y2H Array
32296183
Intra CETN3 O15182 POC5 Homo sapiens Q8NA72-3
SLC
27107012
Intra CETN3 O15182 POC5 Homo sapiens Q8NA72-3
Y2H Array
32296183
Intra CETN3 O15182 POC5 Homo sapiens Q8NA72-3
Y2H Prey Pooling
32296183
Intra CETN3 O15182 POC5 Homo sapiens Q8NA72-3
Y2H
27107012
Intra CETN3 O15182 POC5 Homo sapiens Q8NA72-3
Validated Y2H
32296183
Intra CETN3 O15182 POC5 Homo sapiens Q8NA72
Y2H Array
31515488
Intra CETN3 O15182 POC5 Homo sapiens Q8NA72
Anti Tag CoIP
35271311
Intra CETN3 O15182 POC5 Homo sapiens Q8NA72
Y2H Array
29892012
Intra CETN3 O15182 LDB2 Homo sapiens O43679
Validated Y2H
32296183
Intra CETN3 O15182 LDB2 Homo sapiens O43679
Y2H Array
32296183
Intra CETN3 O15182 LDB2 Homo sapiens O43679
Y2H Prey Pooling
32296183
Intra CETN3 O15182 AGR2 Homo sapiens O95994
Y2H Prey Pooling
32296183
Intra CETN3 O15182 AGR2 Homo sapiens O95994
Validated Y2H
32296183
Intra CETN3 O15182 AGR2 Homo sapiens O95994
Y2H Array
32296183
Intra CETN3 O15182 CKMT2 Homo sapiens P17540
Validated Y2H
32296183
Intra CETN3 O15182 CKMT2 Homo sapiens P17540
Y2H Array
32296183
Intra CETN3 O15182 CKMT2 Homo sapiens P17540
Y2H Prey Pooling
32296183
Intra CETN3 O15182 TNNI1 Homo sapiens P19237
Validated Y2H
32296183
Intra CETN3 O15182 TNNI1 Homo sapiens P19237
Y2H Array
32296183
Intra CETN3 O15182 TNNI1 Homo sapiens P19237
Y2H Prey Pooling
32296183
Intra CETN3 O15182 RCN1 Homo sapiens Q15293
Y2H Prey Pooling
32296183
Intra CETN3 O15182 RCN1 Homo sapiens Q15293
Validated Y2H
32296183
Intra CETN3 O15182 RCN1 Homo sapiens Q15293
Y2H Array
32296183
Intra CETN3 O15182 TCAP Homo sapiens O15273
Anti Tag CoIP
33961781
Intra CETN3 O15182 TCAP Homo sapiens O15273
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Retinitis Pigmentosa 28

RP28

Retinitis Pigmentosa, Type 28
Cranioectodermal Dysplasia 4

CED4

Sensenbrenner Syndrome 4

Dysplasia, Cranioectodermal, Type 4
Microcephalic Osteodysplastic Primordial Dwarfism, Type Ii

Microcephalic Osteodysplastic Primordial Dwarfism Type Ii

Majewski Osteodysplastic Primordial Dwarfism Type Ii

MOPD2

Mopd Ii

Osteodysplastic Primordial Dwarfism Type Ii

Mopdii

Osteodysplastic Primordial Dwarfism Type 2

Osteodysplastic Primordial Dwarfism, Type Ii

Pcnt-Related Microcephalic Osteodysplastic Primordial Dwarfism

Microcephalic Osteodysplastic Primordial Dwarfism Type 2

Mopd 2

Microcephalic Osteodysplastic Primordial Dwarfism With Tooth Abnormalities

Mopd Type Ii

Microcephalic Osteodysplastic Primordial Dwarfism 2

Dwarfism, Primordial, Osteodysplastic, Microcephalic Type Ii
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Cone-Rod Dystrophy 2

Cone-Rod Dystrophy

CORD2

Cone-Rod Retinal Dystrophy

Rcrd2

Cone-Rod Retinal Dystrophy 2

Crd2

Cord

Crd

Retinal Cone-Rod Dystrophy

Cone-Rod Retinal Dystrophy-2

Retinal Cone-Rod Dystrophy 2

Tapetoretinal Degeneration

Cone-Rod Degeneration

Cone Rod Dystrophy

Dystrophy, Cone-Rod

Dystrophy, Cone-Rod, Type 2

Retinitis Pigmentosa

Retinitis Pigmentosa 2

Progressive Cone-Rod Dystrophy
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02548 CETN3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CETN3 VGNC VGNC:71016
Rattus norvegicus CETN3 RGD RGD:620249
Bos taurus CETN3 VGNC VGNC:27235
Felis catus CETN3 VGNC VGNC:60801
Mus musculus CETN3 MGD MGI:1097706
Canis familiaris CETN3 VGNC VGNC:39156