COX6C - cytochrome c oxidase subunit 6C Gene

Homo sapiens

Gene ID: 1345 | Gene type: protein coding

About COX6C

Cytogenetic location: 8q22.2 Genomic coordinates (GRCh38): 8:99,877,865-99,893,707 (from NCBI)

This gene has 11 transcripts (splice variants), 82 orthologues and is associated with 36 phenotypes. Ubiquitous expression in heart (RPKM 104.1), colon (RPKM 92.2) and 25 other tissues.

Summary

Cytochrome c oxidase, the terminal Enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIc, which has 77% amino acid sequence identity with mouse subunit VIc. This gene is up-regulated in prostate Cancer cells. A pseudogene has been found on chromosomes 16p12. [provided by RefSeq, Jul 2010]

COX6C Products(1)

mRNA	Protein	Name
NM_004374.4	NP_004365.1	cytochrome c oxidase subunit 6C

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17500595	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial membrane	IDA IDA: Inferred from direct assay	30030519	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COX6C Protein Structure

COX6C

0
75 a.a.

Protein Preferred Names

Protein Names

cytochrome c oxidase subunit 6C

cytochrome c oxidase polypeptide VIc

COX6C Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	COX6C	P09669	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	COX6C	P09669	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	COX6C	P09669	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	COX6C	P09669	SAT1	Homo sapiens	P21673	Validated Y2H	32296183
Intra	COX6C	P09669	SAT1	Homo sapiens	P21673	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

COX6C Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82866	Cytochrome C Oxidase subunit Vic Antibody (YA2611)	WB, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Leiomyoma

Leiomyomatous Neoplasm	Leiomyomatous Tumor
Leiomyomas	Fibroid Tumor
Uterine Fibroids

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Mitochondrial Complex Iv Deficiency, Nuclear Type 1

Cytochrome C Oxidase Deficiency	Mitochondrial Complex Iv Deficiency
Cox Deficiency	Cytochrome-C Oxidase Deficiency Disease
MC1DN4	Cytochrome-C Oxidase Deficiency
MC4DN1	Mitochondrial Complex I Deficiency, Nuclear Type 4
Complex 4 Mitochondrial Respiratory Chain Deficiency	Complex Iv Deficiency
Mitochondrial Complex 1 Deficiency, Nuclear Type 4	Nuclear Type Mitochondrial Complex I Deficiency 4
Deficiency Of Mitochondrial Respiratory Chain Complex4	MT-C4D
Complex Iv Mitochondrial Respiratory Chain Deficiency	Lethal Neonatal Cardiomyopathy Hypertrophic Due To Cytochrome C Oxidase Deficiency
Mitochondrial Complex Iv Deficiency, Nuclear, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03072	COX6C Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	COX6C	MGD	MGI:104614
Rattus norvegicus	COX6C	RGD	RGD:620616

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