2. Gene
  3. ADAT2 - adenosine deaminase tRNA specific 2 Gene

ADAT2 - adenosine deaminase tRNA specific 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as TAD2; DEADC1; dJ20N2; dJ20N2.1

Gene ID: 134637 | Gene type: protein coding

About ADAT2

Cytogenetic location: 6q24.2 Genomic coordinates (GRCh38): 6:143,422,832-143,450,695 (from NCBI)

This gene has 3 transcripts (splice variants), 198 orthologues and 1 paralogue. Ubiquitous expression in skin (RPKM 2.8), lymph node (RPKM 2.6) and 25 other tissues.

Summary

Predicted to enable tRNA-specific adenosine-34 deaminase activity. Predicted to be involved in tRNA wobble adenosine to inosine editing. Predicted to be located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ADAT2 Products(2)

mRNA Protein Name
NM_001286259.2 NP_001273188.1 tRNA-specific adenosine deaminase 2 isoform b
NM_182503.3 NP_872309.2 tRNA-specific adenosine deaminase 2 isoform a

ADAT2 Protein Structure

dCMP_cyt_deam_1

dCMP_cyt_deam_1: Cytidine and deoxycytidylate deaminase zinc-binding region (21 - 125)

  • 0
  • 100
  • 191 a.a.
Protein Preferred Names Protein Names

tRNA-specific adenosine deaminase 2

adenosine deaminase, tRNA-specific 2, TAD2 homolog

ADAT2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra ADAT2 Q7Z6V5 SMARCD1 Homo sapiens Q96GM5
Validated Y2H
32296183
Intra ADAT2 Q7Z6V5 ADAT3 Homo sapiens Q96EY9
Anti Tag CoIP
33961781
Intra ADAT2 Q7Z6V5 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra ADAT2 Q7Z6V5 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra ADAT2 Q7Z6V5 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra ADAT2 Q7Z6V5 SGTB Homo sapiens Q96EQ0
Y2H Array
32296183
Intra ADAT2 Q7Z6V5 SGTB Homo sapiens Q96EQ0
Y2H Prey Pooling
32296183
Intra ADAT2 Q7Z6V5 SGTB Homo sapiens Q96EQ0
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00321 ADAT2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ADAT2 VGNC VGNC:69490
Felis catus ADAT2 VGNC VGNC:59609
Bos taurus ADAT2 VGNC VGNC:25638
Rattus norvegicus ADAT2 RGD RGD:1309642
Mus musculus ADAT2 MGD MGI:1914007
Canis familiaris ADAT2 VGNC VGNC:37614